HK1140820A1 - 用於在生物樣品中進行稀有事件分析的高靈敏度多參數方法 - Google Patents
用於在生物樣品中進行稀有事件分析的高靈敏度多參數方法Info
- Publication number
- HK1140820A1 HK1140820A1 HK10107242.9A HK10107242A HK1140820A1 HK 1140820 A1 HK1140820 A1 HK 1140820A1 HK 10107242 A HK10107242 A HK 10107242A HK 1140820 A1 HK1140820 A1 HK 1140820A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- biological sample
- event analysis
- rare event
- multiparameter method
- high sensivity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ecology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/181,399 US9134237B2 (en) | 2005-09-20 | 2008-07-29 | High sensitivity multiparameter method for rare event analysis in a biological sample |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1140820A1 true HK1140820A1 (zh) | 2010-10-22 |
Family
ID=41611032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10107242.9A HK1140820A1 (zh) | 2008-07-29 | 2010-07-28 | 用於在生物樣品中進行稀有事件分析的高靈敏度多參數方法 |
Country Status (15)
Country | Link |
---|---|
US (1) | US9134237B2 (zh) |
EP (1) | EP2169387B1 (zh) |
JP (1) | JP6109464B2 (zh) |
KR (2) | KR101764597B1 (zh) |
CN (1) | CN101672779B (zh) |
BR (2) | BRPI0902559A2 (zh) |
CA (2) | CA2975186A1 (zh) |
DK (1) | DK2169387T3 (zh) |
ES (1) | ES2542061T3 (zh) |
HK (1) | HK1140820A1 (zh) |
HU (1) | HUE026779T2 (zh) |
IL (1) | IL199798A (zh) |
MX (1) | MX2009008060A (zh) |
PL (1) | PL2169387T3 (zh) |
PT (1) | PT2169387E (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1941050B1 (en) | 2005-09-20 | 2017-04-26 | Janssen Diagnostics, LLC | Methods and composition to generate unique sequence dna probes, iabeling of dna probes and the use of these probes |
CN107422127A (zh) | 2009-10-21 | 2017-12-01 | 斯克里普斯研究所 | 用非稀有细胞检测稀有细胞的方法 |
ES2721639T3 (es) | 2010-10-06 | 2019-08-02 | Inst Catalana Recerca Estudis Avancats | Método para el diagnóstico, pronóstico y tratamiento de la metástasis de cáncer de mama |
US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
EP2752655A4 (en) * | 2011-08-30 | 2015-06-17 | Olympus Corp | PROCEDURE FOR DETECTING TARGET PARTICLES |
WO2013072571A1 (fr) * | 2011-11-17 | 2013-05-23 | Institut Gustave Roussy | Methode de caracterisation de cellules tumorales circulantes et application au diagnostic |
EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
TR201819859T4 (tr) | 2012-06-06 | 2019-01-21 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Akciğer kanseri metastazının tanısı ve prognozu için yöntem. |
US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
EP3553186B1 (en) | 2012-10-12 | 2021-11-17 | Inbiomotion, S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
WO2014070235A1 (en) | 2012-10-29 | 2014-05-08 | Mbio Diagnostics, Inc. | Biological particle identification system, cartridge and associated methods |
US10527624B2 (en) | 2014-01-27 | 2020-01-07 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for prostate cancer biomarkers |
EA201691682A1 (ru) | 2014-02-21 | 2017-02-28 | Эпик Сайенсиз, Инк. | Способы анализирования редких циркулирующих в крови клеток |
US10871491B2 (en) * | 2014-08-25 | 2020-12-22 | Creatv Microtech, Inc. | Use of circulating cell biomarkers in the blood for detection and diagnosis of diseases and methods of isolating them |
WO2016092524A1 (en) | 2014-12-11 | 2016-06-16 | Inbiomotion S.L. | Binding members for human c-maf |
US10078778B2 (en) * | 2015-01-15 | 2018-09-18 | Massachusetts Institute Of Technology | Systems, methods, and apparatus for in vitro single-cell identification and recovery |
GB201507202D0 (en) | 2015-04-28 | 2015-06-10 | Stfc Science & Technology | Receptor tyosine kinase biomarkers |
CA3007689A1 (en) * | 2016-01-07 | 2017-07-13 | Creatv Micro Tech,Inc. | Multi-phenotypic subtyping of biological samples using sequential fluorescent quenching and restaining |
WO2017203468A1 (en) | 2016-05-25 | 2017-11-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
WO2018017738A1 (en) * | 2016-07-19 | 2018-01-25 | Altius Institute For Biomedical Sciences | Methods for fluorescence imaging microscopy |
CN111565725A (zh) | 2017-11-22 | 2020-08-21 | 生物运动有限公司 | 基于c-maf状态的乳腺癌的治疗性处理 |
CN111330311B (zh) * | 2020-02-13 | 2021-02-23 | 浙江大学 | 一种相变诱导靶标富集的方法 |
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WO1995031481A1 (en) * | 1994-05-18 | 1995-11-23 | The Research And Development Institute, Inc. | Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms |
EP0760008A1 (en) * | 1994-05-19 | 1997-03-05 | Dako A/S | Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis |
WO1997038313A1 (en) | 1996-04-05 | 1997-10-16 | The Johns Hopkins University | A method of enriching rare cells |
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KR20030074816A (ko) * | 2001-02-12 | 2003-09-19 | 이뮤니베스트 코포레이션 | 광학 분석용 시료 샘플을 수용하기 위한 카트리지 |
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US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
CA2516795C (en) | 2003-02-27 | 2013-01-15 | Immunivest Corporation | Circulating tumor cells (ctc's): early assessment of time to progression,_survival and response to therapy in metastatic cancer patients |
DE602004029560D1 (de) * | 2003-03-07 | 2010-11-25 | Rubicon Genomics Inc | Amplifikation und analyse von gesamtgenom- und gesamttranskriptom- bibliotheken, die durch ein dns-polymerisierungsverfahren produziert wurden |
US20050064450A1 (en) * | 2003-03-13 | 2005-03-24 | Lucas Joe N. | Methods of making repetitive sequences removed probes and uses thereof |
US20060241034A1 (en) * | 2003-05-22 | 2006-10-26 | David Chauvier | Means for preventing and treating cellular death and their biological applications |
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DE102005006237A1 (de) * | 2005-02-10 | 2006-08-24 | Henkel Kgaa | Verfahren zur Bestimmung von Keimen |
EP1722231A3 (en) | 2005-04-27 | 2009-03-11 | MPB MelTec Patent- und Beteiligungsgesellschaft mbH | Method for identification of somatic stem cells |
EP1941050B1 (en) | 2005-09-20 | 2017-04-26 | Janssen Diagnostics, LLC | Methods and composition to generate unique sequence dna probes, iabeling of dna probes and the use of these probes |
US7659978B2 (en) * | 2006-10-19 | 2010-02-09 | Chemimage Corporation | Photobleaching by high power pulses |
-
2008
- 2008-07-29 US US12/181,399 patent/US9134237B2/en active Active
-
2009
- 2009-07-09 IL IL199798A patent/IL199798A/en not_active IP Right Cessation
- 2009-07-24 CA CA2975186A patent/CA2975186A1/en not_active Abandoned
- 2009-07-24 CA CA2674187A patent/CA2674187C/en not_active Expired - Fee Related
- 2009-07-27 BR BRPI0902559-6A patent/BRPI0902559A2/pt not_active IP Right Cessation
- 2009-07-27 BR BR122018015761A patent/BR122018015761B8/pt not_active IP Right Cessation
- 2009-07-28 DK DK09251888.5T patent/DK2169387T3/en active
- 2009-07-28 ES ES09251888.5T patent/ES2542061T3/es active Active
- 2009-07-28 JP JP2009175045A patent/JP6109464B2/ja active Active
- 2009-07-28 HU HUE09251888A patent/HUE026779T2/en unknown
- 2009-07-28 PT PT92518885T patent/PT2169387E/pt unknown
- 2009-07-28 EP EP20090251888 patent/EP2169387B1/en not_active Not-in-force
- 2009-07-28 PL PL09251888T patent/PL2169387T3/pl unknown
- 2009-07-29 MX MX2009008060A patent/MX2009008060A/es active IP Right Grant
- 2009-07-29 KR KR1020090069697A patent/KR101764597B1/ko active IP Right Grant
- 2009-07-29 CN CN200910164675.9A patent/CN101672779B/zh not_active Expired - Fee Related
-
2010
- 2010-07-28 HK HK10107242.9A patent/HK1140820A1/zh not_active IP Right Cessation
-
2017
- 2017-07-27 KR KR1020170095373A patent/KR20170094523A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101672779B (zh) | 2016-01-06 |
CN101672779A (zh) | 2010-03-17 |
MX2009008060A (es) | 2010-07-01 |
JP6109464B2 (ja) | 2017-04-05 |
CA2975186A1 (en) | 2010-01-29 |
DK2169387T3 (en) | 2015-05-26 |
EP2169387B1 (en) | 2015-04-22 |
KR101764597B1 (ko) | 2017-08-03 |
BRPI0902559A2 (pt) | 2011-04-05 |
EP2169387A3 (en) | 2011-03-09 |
PT2169387E (pt) | 2015-06-03 |
US20090029378A1 (en) | 2009-01-29 |
HUE026779T2 (en) | 2016-07-28 |
KR20170094523A (ko) | 2017-08-18 |
PL2169387T3 (pl) | 2015-09-30 |
CA2674187A1 (en) | 2010-01-29 |
EP2169387A2 (en) | 2010-03-31 |
IL199798A0 (en) | 2010-05-17 |
CA2674187C (en) | 2017-09-12 |
KR20100012847A (ko) | 2010-02-08 |
JP2010029187A (ja) | 2010-02-12 |
ES2542061T3 (es) | 2015-07-30 |
BR122018015761B8 (pt) | 2021-07-27 |
BR122018015761B1 (pt) | 2019-10-22 |
IL199798A (en) | 2014-08-31 |
US9134237B2 (en) | 2015-09-15 |
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