HK1109903A1 - Amide prodrug of gemcitabine, compositions and use thereof - Google Patents

Amide prodrug of gemcitabine, compositions and use thereof

Info

Publication number
HK1109903A1
HK1109903A1 HK08100464.9A HK08100464A HK1109903A1 HK 1109903 A1 HK1109903 A1 HK 1109903A1 HK 08100464 A HK08100464 A HK 08100464A HK 1109903 A1 HK1109903 A1 HK 1109903A1
Authority
HK
Hong Kong
Prior art keywords
gemcitabine
compositions
amide prodrug
prodrug
amide
Prior art date
Application number
HK08100464.9A
Other languages
English (en)
Inventor
David Michael Bender
David Michael Remick
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1109903A1 publication Critical patent/HK1109903A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK08100464.9A 2004-12-17 2008-01-14 Amide prodrug of gemcitabine, compositions and use thereof HK1109903A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17
PCT/US2005/043125 WO2006065525A1 (en) 2004-12-17 2005-11-30 Amide prodrug of gemcitabine, compositions and use thereof

Publications (1)

Publication Number Publication Date
HK1109903A1 true HK1109903A1 (en) 2008-06-27

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08100464.9A HK1109903A1 (en) 2004-12-17 2008-01-14 Amide prodrug of gemcitabine, compositions and use thereof

Country Status (32)

Country Link
US (1) US7691827B2 (ko)
EP (1) EP1831237B1 (ko)
JP (1) JP5022911B2 (ko)
KR (1) KR100874052B1 (ko)
CN (1) CN101080417B (ko)
AR (1) AR055009A1 (ko)
AT (1) ATE405573T1 (ko)
AU (1) AU2005316922B2 (ko)
BR (1) BRPI0519117A2 (ko)
CA (1) CA2589850C (ko)
CY (1) CY1108447T1 (ko)
DE (1) DE602005009255D1 (ko)
DK (1) DK1831237T3 (ko)
EA (1) EA011868B1 (ko)
ES (1) ES2310860T3 (ko)
HK (1) HK1109903A1 (ko)
HR (1) HRP20080529T3 (ko)
IL (1) IL183666A (ko)
MA (1) MA29154B1 (ko)
MX (1) MX2007007228A (ko)
MY (1) MY143677A (ko)
NO (1) NO20073368L (ko)
NZ (1) NZ554732A (ko)
PE (1) PE20060771A1 (ko)
PL (1) PL1831237T3 (ko)
PT (1) PT1831237E (ko)
RS (1) RS50629B (ko)
SI (1) SI1831237T1 (ko)
TW (1) TWI326687B (ko)
UA (1) UA86119C2 (ko)
WO (1) WO2006065525A1 (ko)
ZA (1) ZA200705019B (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114854B2 (en) 2006-06-21 2012-02-14 Eli Lilly And Company Crystalline forms of gemcitabine amide prodrug, compositions and use thereof
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
EP2916840B1 (en) 2012-11-07 2017-11-01 Nucorion Pharmaceuticals, Inc. Substituted gemcitabine aryl amide analogs
EP2919790B1 (en) 2012-11-13 2018-04-04 Boyen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
US10059733B2 (en) 2014-03-03 2018-08-28 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
WO2019152955A1 (en) 2018-02-02 2019-08-08 Steven Albert Everett Small molecule drug conjugates of gemcitabine monophosphate
JP2021522331A (ja) * 2018-04-26 2021-08-30 ナノメッド ホールディングス プロプライエタリー リミテッド ジェムシタビン両親媒性プロドラッグ
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
EP3817732A4 (en) * 2018-08-03 2022-06-08 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
CN115605492A (zh) 2020-04-21 2023-01-13 配体制药股份有限公司（Us） 核苷酸前药化合物
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
SK283879B6 (sk) * 1997-01-24 2004-04-06 Conpharma As Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
AU2003291726A1 (en) * 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
ZA200705019B (en) 2008-10-29
CY1108447T1 (el) 2014-04-09
AR055009A1 (es) 2007-08-01
KR100874052B1 (ko) 2008-12-12
US7691827B2 (en) 2010-04-06
UA86119C2 (ru) 2009-03-25
NO20073368L (no) 2007-07-16
US20090156547A1 (en) 2009-06-18
EA200701300A1 (ru) 2007-10-26
JP2008524218A (ja) 2008-07-10
TWI326687B (en) 2010-07-01
TW200634023A (en) 2006-10-01
MA29154B1 (fr) 2008-01-02
MX2007007228A (es) 2007-08-14
DK1831237T3 (da) 2008-10-27
CN101080417A (zh) 2007-11-28
MY143677A (en) 2011-06-30
RS50629B (sr) 2010-06-30
EP1831237B1 (en) 2008-08-20
EA011868B1 (ru) 2009-06-30
JP5022911B2 (ja) 2012-09-12
EP1831237A1 (en) 2007-09-12
KR20070086308A (ko) 2007-08-27
BRPI0519117A2 (pt) 2008-12-23
CN101080417B (zh) 2011-01-19
ATE405573T1 (de) 2008-09-15
PL1831237T3 (pl) 2009-01-30
SI1831237T1 (sl) 2009-02-28
WO2006065525A1 (en) 2006-06-22
AU2005316922A1 (en) 2006-06-22
CA2589850A1 (en) 2006-06-22
ES2310860T3 (es) 2009-01-16
AU2005316922B2 (en) 2011-08-25
HRP20080529T3 (en) 2008-12-31
IL183666A0 (en) 2007-09-20
NZ554732A (en) 2010-09-30
PE20060771A1 (es) 2006-09-23
DE602005009255D1 (de) 2008-10-02
IL183666A (en) 2011-09-27
CA2589850C (en) 2012-05-01
PT1831237E (pt) 2008-09-22

Similar Documents

Publication Publication Date Title
ZA200705019B (en) Amide prodrug of gemcitabine, compositions and use thereof
IL204977A0 (en) Amide inhibitors of voltage-gated sodium channels, compositions comprising the same and uses thereof
IL191937A0 (en) Levodopa prodrug mesylate, compositions thereof and uses thereof
HK1099927A1 (en) Levodopa derivatives, and compositions and uses thereof
IL189011A0 (en) COMPOSITIONS OF tRNA AND USES THEREOF
EP2061476A4 (en) COMPOSITIONS WITH CDP-CHOLINE AND METHOD OF USE THEREOF
PL2335782T3 (pl) Zastosowanie kompozycji zawierającej HFCO-1233zd
IL190506A0 (en) Amide derivatives and pesticidal compositions containing the same
SI2057153T1 (sl) (3-ril-piperazin-1-il) derivati 6,7-dialkoksikuinazolin, 6,7-dialkoksiftalazin in 6,7-dialkoksiizokuinolin
ZA200704295B (en) Arthrospira-based compositions and uses thereof
ZA200700809B (en) Corrosion-inhibiting compositions and use thereof
EP1954685A4 (en) FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
IL182126A (en) Preparations containing and used in the history of 5-phenoxyalkoxypsoralen
LT1858481T (lt) Oftalmologinės kompozicijos ir jų panaudojimas
EP1848438A4 (en) DIAMINOPHENOTHIAZINE COMPOSITIONS AND THEIR USE
EP1991059A4 (en) INSECTICIDAL COMPOSITIONS AND USES THEREOF
HK1101136A1 (en) Compositions against sars-coronavirus and uses thereof
IL186337A0 (en) Stannsoporfin compositions and administration
GB2423081B (en) Pro-fragrance and pro-flavorant compositions
IL186606A0 (en) Compositions and uses of amooranin compounds
EP1937292A4 (en) LOPAP-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
ZA200707529B (en) Pro-fragrance and pro-flavorant compositions
EP1761244A4 (en) ISOCYANATE COMPOSITIONS AND USE THEREOF
EP1865777A4 (en) STANNSOPORFIN COMPOSITIONS AND ADMINISTRATION
GB0424051D0 (en) Compounds and compositions

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20151130