HK1106153A1 - Composition comprising an hmg-coa inhibitor and a nicotinic acid compound for treating hyperlipidemia - Google Patents

Composition comprising an hmg-coa inhibitor and a nicotinic acid compound for treating hyperlipidemia

Info

Publication number
HK1106153A1
HK1106153A1 HK07111713.6A HK07111713A HK1106153A1 HK 1106153 A1 HK1106153 A1 HK 1106153A1 HK 07111713 A HK07111713 A HK 07111713A HK 1106153 A1 HK1106153 A1 HK 1106153A1
Authority
HK
Hong Kong
Prior art keywords
nicotinic acid
nicotinamide
methyl
composition
hmg
Prior art date
Application number
HK07111713.6A
Other languages
English (en)
Inventor
David J Bova
Josephine Dunne
Original Assignee
Kos Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kos Life Sciences Inc filed Critical Kos Life Sciences Inc
Publication of HK1106153A1 publication Critical patent/HK1106153A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK07111713.6A 1997-07-31 2007-10-30 Composition comprising an hmg-coa inhibitor and a nicotinic acid compound for treating hyperlipidemia HK1106153A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90375297A 1997-07-31 1997-07-31

Publications (1)

Publication Number Publication Date
HK1106153A1 true HK1106153A1 (en) 2008-03-07

Family

ID=25418027

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07111713.6A HK1106153A1 (en) 1997-07-31 2007-10-30 Composition comprising an hmg-coa inhibitor and a nicotinic acid compound for treating hyperlipidemia

Country Status (17)

Country Link
US (3) US20040053975A1 (de)
EP (2) EP1792616B1 (de)
JP (2) JP4870869B2 (de)
AT (2) ATE359785T1 (de)
AU (1) AU752673B2 (de)
BR (1) BR9815548A (de)
CA (1) CA2298549C (de)
CY (1) CY1107057T1 (de)
DE (2) DE69841395D1 (de)
DK (1) DK1017390T3 (de)
ES (2) ES2336492T3 (de)
HK (1) HK1106153A1 (de)
IL (2) IL134271A0 (de)
NO (1) NO20000439L (de)
NZ (1) NZ520176A (de)
PT (1) PT1017390E (de)
WO (1) WO1999006035A2 (de)

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US7176310B1 (en) 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
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CN100415235C (zh) * 2002-08-02 2008-09-03 三共株式会社 含有HMG-CoA还原酶抑制剂的药物组合物
WO2004012740A1 (ja) * 2002-08-02 2004-02-12 Sankyo Company, Limited HMG-CoAリダクターゼ阻害剤を含有する医薬組成物
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EP2805719A1 (de) * 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamidribosid und Analoge davon
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
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US20070149466A1 (en) * 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
ATE548035T1 (de) * 2005-07-11 2012-03-15 Cortria Corp Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat
KR20070063350A (ko) * 2005-12-14 2007-06-19 주식회사종근당 서방형 방출층과 속방형 방출층을 포함한 고지혈증 및동맥경화를 치료를 위한 약제학적 조성물
CA2569776A1 (en) * 2006-02-17 2007-08-17 Kos Life Sciences, Inc. Low flush niacin formulation
US8784886B2 (en) 2006-03-09 2014-07-22 GlaxoSmithKline, LLC Coating capsules with active pharmaceutical ingredients
EP2081550B2 (de) * 2006-03-09 2021-05-26 Reliant Pharmaceuticals, Inc. Beschichtung von kapseln mit pharmazeutischen wirkstoffen
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
WO2008023958A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmaceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
DE102007003524A1 (de) * 2007-01-19 2008-09-04 MEDICE Arzneimittel Pütter GmbH & Co. KG Arzneimittel zur Behandlung und/oder Prävention von Arteriosklerose
KR100885029B1 (ko) * 2007-02-07 2009-02-23 지엘팜텍 주식회사 경구투여용 서방성 삼중정제
WO2009016577A2 (en) * 2007-07-27 2009-02-05 Ranbaxy Laboratories Limited A pharmaceutical composition comprising atorvastatin and niacin
CN101951896B (zh) * 2008-02-22 2012-11-28 韩兀生物制药株式会社 复合制剂
KR20090091075A (ko) * 2008-02-22 2009-08-26 한올제약주식회사 심혈관계 질환 치료용 약제학적 제제
CN102014881A (zh) * 2008-02-22 2011-04-13 韩兀生物制药株式会社 药物制剂
CA2724594A1 (en) * 2008-05-20 2009-11-26 John R. Wetterau Niacin and nsaid combination therapy
US20110086074A1 (en) * 2008-06-02 2011-04-14 Dr. Reddy's Laboratories Ltd. Combinations of niacin and an oxicam
MX2010013169A (es) * 2008-06-02 2010-12-21 Reddy S Lab Ltd Formulaciones de niacina de liberacion modificada.
US20100178341A1 (en) * 2008-06-11 2010-07-15 Ranbaxy Laboratories Limited BILAYERED TABLET COMPRISING NIACIN AND HMG-CoA REDUCTASE INHIBITOR
WO2010005581A1 (en) * 2008-07-11 2010-01-14 Kareus Therapeutics, Llc Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad)
AR076835A1 (es) * 2009-05-01 2011-07-13 Eurand Inc Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de drogas en dosis elevadas y reducidas. metodo.
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Also Published As

Publication number Publication date
US20040053975A1 (en) 2004-03-18
DE69837610D1 (de) 2007-05-31
JP4870869B2 (ja) 2012-02-08
US20120164221A1 (en) 2012-06-28
US20090226518A1 (en) 2009-09-10
EP1792616A1 (de) 2007-06-06
NO20000439D0 (no) 2000-01-27
WO1999006035A2 (en) 1999-02-11
NZ520176A (en) 2005-02-25
NO20000439L (no) 2000-03-22
WO1999006035A3 (en) 1999-04-22
CY1107057T1 (el) 2012-10-24
EP1792616B1 (de) 2009-12-16
AU8680198A (en) 1999-02-22
ATE359785T1 (de) 2007-05-15
DE69841395D1 (de) 2010-01-28
IL134271A (en) 2006-07-05
IL134271A0 (en) 2001-04-30
JP2009235105A (ja) 2009-10-15
ES2336492T3 (es) 2010-04-13
BR9815548A (pt) 2000-11-07
EP1017390A2 (de) 2000-07-12
ATE451926T1 (de) 2010-01-15
DE69837610T2 (de) 2008-01-03
AU752673B2 (en) 2002-09-26
DK1017390T3 (da) 2007-06-11
JP2001511444A (ja) 2001-08-14
ES2283067T3 (es) 2007-10-16
CA2298549C (en) 2006-01-10
PT1017390E (pt) 2007-07-24
EP1017390B1 (de) 2007-04-18
CA2298549A1 (en) 1999-02-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150731