HK1089159A1 - Inhibitors of nucleoside metabolism - Google Patents

Inhibitors of nucleoside metabolism

Info

Publication number
HK1089159A1
HK1089159A1 HK06109456A HK06109456A HK1089159A1 HK 1089159 A1 HK1089159 A1 HK 1089159A1 HK 06109456 A HK06109456 A HK 06109456A HK 06109456 A HK06109456 A HK 06109456A HK 1089159 A1 HK1089159 A1 HK 1089159A1
Authority
HK
Hong Kong
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
HK06109456A
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Publication of HK1089159A1 publication Critical patent/HK1089159A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HK06109456A 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism HK1089159A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
HK1089159A1 true HK1089159A1 (en) 2006-11-24

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109456A HK1089159A1 (en) 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism

Country Status (14)

Country Link
US (7) US5985848A (fr)
EP (1) EP1023308B1 (fr)
JP (1) JP4451983B2 (fr)
KR (1) KR100637479B1 (fr)
CN (2) CN1220695C (fr)
AT (1) ATE304019T1 (fr)
AU (1) AU749098B2 (fr)
CA (1) CA2305760C (fr)
DE (1) DE69831499T2 (fr)
DK (1) DK1023308T3 (fr)
ES (1) ES2249844T3 (fr)
HK (1) HK1089159A1 (fr)
PT (1) PT1023308E (fr)
WO (1) WO1999019338A1 (fr)

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US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
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ES2625636T3 (es) * 1999-04-08 2017-07-20 Victoria Link Limited Proceso para preparar inhibidores del metabolismo de nucleósidos
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US6387923B2 (en) * 2000-03-22 2002-05-14 Biocryst Pharmacueticals, Inc. Imminoribitol PNP inhibitors, preparation thereof and use thereof
WO2002018371A1 (fr) * 2000-08-29 2002-03-07 Industrial Research Limited Inhibiteurs du metabolisme des nucleosides
US20040076809A1 (en) * 2001-09-13 2004-04-22 Spears Ward R. Composite flywheel rim having commingled layers with macroscopically uniform patterns of fiber arrangement and methods for manufacturing same
US6660719B2 (en) * 2001-12-17 2003-12-09 Biocryst Pharmaceuticals Inc. Inhibiting T-Cell proliferation
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
WO2003100009A2 (fr) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Augmentation de l'efficacite d'inhibiteurs de la transcriptase inverse et d'adn polymerase (analogues de nucleoside) a l'aide d'inhibiteurs de pnp et/ou de 2'-deoxyguanosine et/ou d'un promedicament de ceux-ci
SI1539783T1 (sl) * 2002-08-21 2011-08-31 Einstein Coll Med Inhibitorji nukleozidnih fosforilaz in nukleozidaz
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EP1991230A4 (fr) * 2006-02-24 2010-12-15 Einstein Coll Med Méthodes de traitement du cancer
WO2007097648A1 (fr) * 2006-02-24 2007-08-30 Industrial Research Limited Méthodes de traitement de maladies en utilisant des inhibiteurs de nucléoside phosphorylases et de nucléosidases
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
US8383636B2 (en) * 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
PL2057165T3 (pl) 2006-09-07 2011-08-31 Victoria Link Ltd Acykliczne inhibitory aminowe fosforylaz i hydrolaz nukleozydowych
PT2114925E (pt) * 2006-12-22 2012-05-29 Einstein Coll Med Análogos de azetidina de inibidores de nucleosidase e fosforilase
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CN102014957B (zh) 2008-04-21 2014-12-10 奥德纳米有限公司 用于治疗耳部疾病和病况的耳用调配物
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
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US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
DK2454263T3 (en) 2009-07-17 2018-10-01 Albert Einstein College Medicine Inc 3-HYDROXYPYRROLIDE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND - NUCLEOSIDASE
MX348759B (es) 2010-10-15 2017-06-28 Biocryst Pharm Inc Metodos y composiciones para inhibicion de polimerasa.
US9290501B2 (en) * 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP2014505705A (ja) 2011-02-02 2014-03-06 ザ トラスティーズ オブ プリンストン ユニヴァシティ ウイルス生成モジュレーターとしてのサーチュインモジュレーター
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WO2013149258A2 (fr) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions et procédés de traitement ou de prévention de troubles du syndrome métabolique
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
AR092198A1 (es) 2012-08-24 2015-04-08 Glaxosmithkline Llc Derivados de pirazolopirimidinas
NZ707319A (en) * 2012-11-20 2019-09-27 Glaxosmithkline Llc 5h-pyrrolo[3,2-d]pyrimidin-4-amine compounds and their use in the treatment of allergic diseases and other inflammatory conditions
JP6216387B2 (ja) * 2012-11-20 2017-10-18 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 新規化合物
AU2013348216B2 (en) * 2012-11-20 2016-10-13 Glaxosmithkline Llc Novel compounds
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9616129B2 (en) 2013-06-22 2017-04-11 Nitor Therapeutics Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
EP3104707B1 (fr) 2014-02-12 2020-07-15 Albert Einstein College of Medicine, Inc. Traitement d'infections dues à h pylori à l'aide d'inhibiteurs de la mtan
CA2973152A1 (fr) * 2015-01-07 2016-07-14 Euro-Celtique S.A. Procede de fabrication de forodesine
MA43812A (fr) 2016-03-06 2018-11-28 Biocryst Pharm Inc Procédés et compositions pour le traitement d'une infection par le virus zika
KR20190024983A (ko) 2016-06-29 2019-03-08 오토노미, 인코포레이티드 트리글리세라이드 귀 제제 및 이의 용도
US20220054494A1 (en) 2019-03-13 2022-02-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
WO2023022216A1 (fr) 2021-08-20 2023-02-23 塩野義製薬株式会社 Dérivés nucléosidiques et leurs promédicaments ayant une action inhibitrice de la croissance virale
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

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SI1539783T1 (sl) 2002-08-21 2011-08-31 Einstein Coll Med Inhibitorji nukleozidnih fosforilaz in nukleozidaz
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (fr) 2004-07-27 2009-07-15 Biocryst Pharm Inc Inhibiteurs de 5'-methylthioadenosine phosphorylase et 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097648A1 (fr) 2006-02-24 2007-08-30 Industrial Research Limited Méthodes de traitement de maladies en utilisant des inhibiteurs de nucléoside phosphorylases et de nucléosidases
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Also Published As

Publication number Publication date
CN100393722C (zh) 2008-06-11
CN1279686A (zh) 2001-01-10
US6066722A (en) 2000-05-23
US20050026936A1 (en) 2005-02-03
AU749098B2 (en) 2002-06-20
US20030096830A1 (en) 2003-05-22
US6492347B2 (en) 2002-12-10
CN1220695C (zh) 2005-09-28
US5985848A (en) 1999-11-16
US7211653B2 (en) 2007-05-01
ES2249844T3 (es) 2006-04-01
DE69831499D1 (de) 2005-10-13
EP1023308B1 (fr) 2005-09-07
ATE304019T1 (de) 2005-09-15
AU1086699A (en) 1999-05-03
US7390890B2 (en) 2008-06-24
PT1023308E (pt) 2005-11-30
US6803455B2 (en) 2004-10-12
WO1999019338A1 (fr) 1999-04-22
DE69831499T2 (de) 2006-06-14
DK1023308T3 (da) 2006-01-23
KR100637479B1 (ko) 2006-10-20
CA2305760C (fr) 2008-06-03
EP1023308A1 (fr) 2000-08-02
EP1023308A4 (fr) 2002-05-29
KR20010031082A (ko) 2001-04-16
CA2305760A1 (fr) 1999-04-22
JP2001519437A (ja) 2001-10-23
US6228847B1 (en) 2001-05-08
CN1757646A (zh) 2006-04-12
US20020061898A1 (en) 2002-05-23
JP4451983B2 (ja) 2010-04-14
US20070197561A1 (en) 2007-08-23

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Effective date: 20181013