HK1041825B - 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 - Google Patents

多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 Download PDF

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Publication number
HK1041825B
HK1041825B HK02103707.6A HK02103707A HK1041825B HK 1041825 B HK1041825 B HK 1041825B HK 02103707 A HK02103707 A HK 02103707A HK 1041825 B HK1041825 B HK 1041825B
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HK
Hong Kong
Prior art keywords
polysaccharide
oligosaccharide
protein
group
conjugate
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HK02103707.6A
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English (en)
Chinese (zh)
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HK1041825A1 (en
Inventor
Michon Francis
Huang Chun-Hsien
Uitz Catherine
Original Assignee
Baxter Healthcare S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Baxter Healthcare S.A. filed Critical Baxter Healthcare S.A.
Publication of HK1041825A1 publication Critical patent/HK1041825A1/xx
Publication of HK1041825B publication Critical patent/HK1041825B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK02103707.6A 1998-08-19 1999-08-18 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 HK1041825B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9712098P 1998-08-19 1998-08-19
US60/097,120 1998-08-19
US37691199A 1999-08-18 1999-08-18
PCT/US1999/018982 WO2000010599A2 (en) 1998-08-19 1999-08-18 IMMUNOGENIC β-PROPIONAMIDO-LINKED POLYSACCHARIDE PROTEIN CONJUGATE USEFUL AS A VACCINE PRODUCED USING AN N-ACRYLOYLATED POLYSACCHARIDE
US09/376,911 1999-08-18

Publications (2)

Publication Number Publication Date
HK1041825A1 HK1041825A1 (en) 2002-07-26
HK1041825B true HK1041825B (zh) 2007-02-23

Family

ID=26792625

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02103707.6A HK1041825B (zh) 1998-08-19 1999-08-18 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用

Country Status (15)

Country Link
US (1) US20040213804A1 (https=)
EP (1) EP1109576B1 (https=)
JP (1) JP2004505885A (https=)
KR (1) KR100704826B1 (https=)
CN (1) CN1263510C (https=)
AT (1) ATE446107T1 (https=)
AU (1) AU771330B2 (https=)
CA (1) CA2340692A1 (https=)
CZ (1) CZ2001622A3 (https=)
DE (1) DE69941574D1 (https=)
HK (1) HK1041825B (https=)
HU (1) HUP0103100A3 (https=)
NO (1) NO20010805L (https=)
NZ (1) NZ509986A (https=)
WO (1) WO2000010599A2 (https=)

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HUP0103100A2 (hu) 2001-11-28
WO2000010599A8 (en) 2000-08-10
AU5780099A (en) 2000-03-14
JP2004505885A (ja) 2004-02-26
KR100704826B1 (ko) 2007-04-09
CN1263510C (zh) 2006-07-12
KR20010072776A (ko) 2001-07-31
NO20010805L (no) 2001-04-03
CA2340692A1 (en) 2000-03-02
CN1323221A (zh) 2001-11-21
NO20010805D0 (no) 2001-02-16
DE69941574D1 (de) 2009-12-03
HK1041825A1 (en) 2002-07-26
US20040213804A1 (en) 2004-10-28
CZ2001622A3 (cs) 2002-01-16
ATE446107T1 (de) 2009-11-15
WO2000010599A2 (en) 2000-03-02
HUP0103100A3 (en) 2005-11-28
AU771330B2 (en) 2004-03-18
EP1109576B1 (en) 2009-10-21
NZ509986A (en) 2003-10-31
EP1109576A2 (en) 2001-06-27
WO2000010599A3 (en) 2000-06-22

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