HK1037643A1 - Method for purifying hemoglobin. - Google Patents

Method for purifying hemoglobin.

Info

Publication number
HK1037643A1
HK1037643A1 HK01108725A HK01108725A HK1037643A1 HK 1037643 A1 HK1037643 A1 HK 1037643A1 HK 01108725 A HK01108725 A HK 01108725A HK 01108725 A HK01108725 A HK 01108725A HK 1037643 A1 HK1037643 A1 HK 1037643A1
Authority
HK
Hong Kong
Prior art keywords
column
hemoglobin
buffer solution
solution
hydroxymethyl
Prior art date
Application number
HK01108725A
Other languages
English (en)
Inventor
Robert A Houtchens
Carl W Rausch
Original Assignee
Biopure Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopure Corp filed Critical Biopure Corp
Publication of HK1037643A1 publication Critical patent/HK1037643A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK01108725A 1998-07-10 2001-12-12 Method for purifying hemoglobin. HK1037643A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/113,953 US6150507A (en) 1995-03-23 1998-07-10 Method for producing a purified hemoglobin product
PCT/US1999/013922 WO2000002921A1 (en) 1998-07-10 1999-06-21 Method for purifying hemoglobin

Publications (1)

Publication Number Publication Date
HK1037643A1 true HK1037643A1 (en) 2002-02-15

Family

ID=22352497

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01108725A HK1037643A1 (en) 1998-07-10 2001-12-12 Method for purifying hemoglobin.

Country Status (13)

Country Link
US (1) US6150507A (es)
EP (1) EP1097171B1 (es)
JP (1) JP4581110B2 (es)
CN (1) CN1166689C (es)
AT (1) ATE347564T1 (es)
AU (1) AU755280B2 (es)
CA (1) CA2336808C (es)
DE (1) DE69934312T2 (es)
DK (1) DK1097171T3 (es)
ES (1) ES2278450T3 (es)
HK (1) HK1037643A1 (es)
NZ (1) NZ509257A (es)
WO (1) WO2000002921A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001076507A2 (en) 2000-04-11 2001-10-18 The University Of Miami Use of oxygen carriers to improve grafted cell survival in neural transplantation
FR2824568B1 (fr) * 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
ES2629602T5 (es) * 2002-09-11 2021-06-08 Genentech Inc Purificación de proteínas
JP2006502231A (ja) * 2002-10-03 2006-01-19 ノースフィールド ラボラトリーズ、インコーポレイテッド 大量失血を被っている患者の処置方法
AU2004207595B2 (en) * 2003-01-29 2009-02-05 Northfield Laboratories, Inc. Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
AU2004309285A1 (en) * 2003-12-26 2005-07-14 Waseda University Process for purification of hemoglobin
US20090117207A1 (en) * 2005-11-29 2009-05-07 Zoltani Csaba K Methods and compositions for treatment of poison-caused pathology
EP1978802A2 (en) 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP2054498A1 (de) * 2006-08-15 2009-05-06 Basf Se Verfahren zur isolierung von proteinen aus produktionszellen
JP2011207853A (ja) * 2010-03-30 2011-10-20 Terumo Corp 人工酸素運搬体製造に用いるヘモグロビン原料中間生成物
JP6786917B2 (ja) * 2016-07-08 2020-11-18 東ソー株式会社 ヘモグロビン調製液及びヘモグロビン類測定液体クロマトグラフィー法
JP6600123B1 (ja) * 2018-04-18 2019-10-30 積水メディカル株式会社 ヘモグロビン分析方法
CN110128531B (zh) * 2019-05-17 2022-03-08 润方（北京）生物医药研究院有限公司 一种无碳酸酐酶血红蛋白的制备方法
CN110563836A (zh) * 2019-09-09 2019-12-13 润方（北京）生物医药研究院有限公司 交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4059512A (en) * 1974-12-27 1977-11-22 Preventive Systems, Inc. Process for removing endotoxin from biological fluids
US3959128A (en) * 1974-12-27 1976-05-25 Preventive Systems, Inc Process for removing endotoxin from biological fluids
DK144800C (da) * 1980-04-21 1982-10-25 Forenede Bryggerier As Fremgangsmaade til udvinding af enzymer,fortrinsvis cu,zn-superoxid-dismutase (sod),catalase og carbonsyreanhydrase,fra blod
US4381239A (en) * 1981-02-10 1983-04-26 Tanabe Seiyaku Co., Ltd. Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
US4473647A (en) * 1981-02-27 1984-09-25 Amf Inc. Tissue culture medium
US4468330A (en) * 1981-04-27 1984-08-28 Sekisui Kagaku Kogyo Kabushiki Kaisha Filler for liquid chromatography useful for separating a hemoglobin variant in blood
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
CA1244349A (en) * 1985-06-26 1988-11-08 Jen-Chang Hsia Purification of hemoglobin and modified hemoglobin by affinity chromatography
GB8600582D0 (en) * 1986-01-10 1986-02-19 Ca Minister Nat Defence Purifying biological materials
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
CA1312009C (en) * 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
AU622610B2 (en) * 1986-11-10 1992-04-16 Biopure Corporation Extra pure semi-synthetic blood substitute
JP2592973B2 (ja) * 1988-06-15 1997-03-19 バクスター インターナショナル インコーポレーテッド 架橋ヘモグロビンの精製方法
CA1338244C (en) * 1988-08-17 1996-04-09 Xiang-Fu Wu Purification of hemoglobin and methemoglobin by bioselective elution
US5128452A (en) * 1989-04-19 1992-07-07 Baxter International Inc. Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
DE69108258T2 (de) * 1990-11-29 1995-08-10 Upjohn Co Mit imidoester quer-vernetzte hämoglobinzusammensetzungen.
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
NZ305258A (en) * 1995-03-23 2000-10-27 Biopure Corp Stable polymerised haemoglobin blood-substitute to treat or prevent hypoxia resulting from blood loss

Also Published As

Publication number Publication date
CN1308636A (zh) 2001-08-15
DE69934312D1 (de) 2007-01-18
WO2000002921A1 (en) 2000-01-20
AU4700399A (en) 2000-02-01
EP1097171B1 (en) 2006-12-06
ATE347564T1 (de) 2006-12-15
DE69934312T2 (de) 2007-07-12
ES2278450T3 (es) 2007-08-01
EP1097171A1 (en) 2001-05-09
CN1166689C (zh) 2004-09-15
JP4581110B2 (ja) 2010-11-17
US6150507A (en) 2000-11-21
DK1097171T3 (da) 2007-04-10
JP2002520338A (ja) 2002-07-09
CA2336808C (en) 2008-08-19
NZ509257A (en) 2003-03-28
AU755280B2 (en) 2002-12-05
CA2336808A1 (en) 2000-01-20

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170621