HK1032394A1 - Trisubstituted 1,3,5-triazine derivatives for tratment of hiv infections. - Google Patents

Trisubstituted 1,3,5-triazine derivatives for tratment of hiv infections.

Info

Publication number
HK1032394A1
HK1032394A1 HK01102801A HK01102801A HK1032394A1 HK 1032394 A1 HK1032394 A1 HK 1032394A1 HK 01102801 A HK01102801 A HK 01102801A HK 01102801 A HK01102801 A HK 01102801A HK 1032394 A1 HK1032394 A1 HK 1032394A1
Authority
HK
Hong Kong
Prior art keywords
tratment
trisubstituted
triazine derivatives
hiv infections
hiv
Prior art date
Application number
HK01102801A
Other languages
English (en)
Inventor
Frederik Frans Desire Daeyaert
Bart De Corte
Marc Rene De Jonge
Jan Heeres
Chih Yung Ho
Paul Adriaan Jan Janssen
Robert W Kavash
Lucien Maria Henricus Koymans
Michael Joseph Kukla
Donald William Ludovici
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1032394A1 publication Critical patent/HK1032394A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK01102801A 1998-03-27 2001-04-20 Trisubstituted 1,3,5-triazine derivatives for tratment of hiv infections. HK1032394A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7963398P 1998-03-27 1998-03-27
EP98201589A EP0945447A1 (de) 1998-03-27 1998-05-14 Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen
PCT/EP1999/002044 WO1999050256A1 (en) 1998-03-27 1999-03-24 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Publications (1)

Publication Number Publication Date
HK1032394A1 true HK1032394A1 (en) 2001-07-20

Family

ID=22151790

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01102801A HK1032394A1 (en) 1998-03-27 2001-04-20 Trisubstituted 1,3,5-triazine derivatives for tratment of hiv infections.

Country Status (33)

Country Link
US (3) US6150360A (de)
EP (2) EP0945447A1 (de)
JP (1) JP2002511390A (de)
KR (1) KR100593396B1 (de)
CN (1) CN1157386C (de)
AP (1) AP1475A (de)
AR (1) AR018169A1 (de)
AT (1) ATE295355T1 (de)
AU (1) AU758624C (de)
BG (1) BG64903B1 (de)
BR (1) BR9909197A (de)
CA (1) CA2324921C (de)
DE (1) DE69925256T2 (de)
DK (1) DK1066269T3 (de)
EA (1) EA004540B1 (de)
EE (1) EE200000535A (de)
ES (1) ES2243056T3 (de)
HK (1) HK1032394A1 (de)
HR (1) HRP20000621A2 (de)
HU (1) HUP0101372A3 (de)
ID (1) ID26043A (de)
IL (1) IL138670A (de)
NO (1) NO317425B1 (de)
NZ (1) NZ506787A (de)
OA (1) OA11493A (de)
PL (1) PL194660B1 (de)
PT (1) PT1066269E (de)
SI (1) SI1066269T1 (de)
SK (1) SK14052000A3 (de)
TR (1) TR200002761T2 (de)
TW (1) TW570917B (de)
WO (1) WO1999050256A1 (de)
ZA (1) ZA200006042B (de)

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US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
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DK1282607T3 (en) 2000-05-08 2016-02-01 Janssen Pharmaceutica Nv Prodrugs of HIV replication inhibiting pyrimidines
US6858608B2 (en) * 2001-01-09 2005-02-22 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agents
US6887873B2 (en) * 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
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US7112587B2 (en) * 2001-09-21 2006-09-26 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7132423B2 (en) * 2001-09-21 2006-11-07 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7173032B2 (en) * 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
IL160984A0 (en) * 2001-09-21 2004-08-31 Reddy Us Therapeutics Inc Triazine derivatives and pharmaceutical compositions containing the same
US7169785B2 (en) * 2001-09-21 2007-01-30 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
EP1441683A4 (de) * 2001-10-12 2005-10-26 Univ New York Trisubstituierte triazin-verbindungen und verfahren zur herstellung und verwendung der verbindungen mit antitubulin-wirkung
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US7585861B2 (en) * 2003-02-07 2009-09-08 Janssen Pharmaceutica, N.V. HIV inhibiting 1,2,4-triazines
US20070232572A1 (en) * 2003-02-07 2007-10-04 Aventis Pharma S.A. Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent
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US6875781B2 (en) * 2003-04-04 2005-04-05 Cell Therapeutics, Inc. Pyridines and uses thereof
CN1822843B (zh) 2003-07-17 2010-04-28 泰博特克药品有限公司 制备含有抗病毒药物颗粒的方法
CA2533397A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
US7335770B2 (en) * 2004-03-24 2008-02-26 Reddy U5 Therapeutics, Inc. Triazine compounds and their analogs, compositions, and methods
ES2442857T3 (es) 2004-08-10 2014-02-13 Janssen Pharmaceutica Nv Derivados de 1,2,4-triazin-6-ona inhibidores de VIH
BRPI0515935B8 (pt) 2004-09-30 2021-05-25 Janssen Sciences Ireland Uc pirimidinas heterociclil- ou 5-carbo substituídas para inibição de hiv, e composição farmacêutica
CN101031558B (zh) 2004-09-30 2011-10-05 泰博特克药品有限公司 抑制人类免疫缺陷病毒的5-杂环基嘧啶
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Also Published As

Publication number Publication date
TR200002761T2 (tr) 2001-01-22
AU758624B2 (en) 2003-03-27
US6774235B2 (en) 2004-08-10
BR9909197A (pt) 2000-12-05
NO20004809D0 (no) 2000-09-26
JP2002511390A (ja) 2002-04-16
DE69925256T2 (de) 2006-02-23
WO1999050256A1 (en) 1999-10-07
BG104716A (en) 2001-04-30
PL194660B1 (pl) 2007-06-29
ATE295355T1 (de) 2005-05-15
KR100593396B1 (ko) 2006-06-28
NZ506787A (en) 2003-02-28
CA2324921C (en) 2009-05-12
AU758624C (en) 2004-03-11
NO20004809L (no) 2000-11-24
EE200000535A (et) 2002-04-15
IL138670A (en) 2005-12-18
DK1066269T3 (da) 2005-09-05
PT1066269E (pt) 2005-09-30
US6150360A (en) 2000-11-21
US20020115668A1 (en) 2002-08-22
EP1066269A1 (de) 2001-01-10
AP2000001913A0 (en) 2000-09-30
HRP20000621A2 (en) 2001-04-30
OA11493A (en) 2004-05-07
SK14052000A3 (sk) 2001-06-11
CN1295566A (zh) 2001-05-16
PL343195A1 (en) 2001-07-30
AR018169A1 (es) 2001-10-31
BG64903B1 (bg) 2006-08-31
NO317425B1 (no) 2004-10-25
EA004540B1 (ru) 2004-06-24
CN1157386C (zh) 2004-07-14
AP1475A (en) 2005-10-03
ES2243056T3 (es) 2005-11-16
ID26043A (id) 2000-11-16
CA2324921A1 (en) 1999-10-07
KR20010034270A (ko) 2001-04-25
EP1066269B1 (de) 2005-05-11
AU3599799A (en) 1999-10-18
HUP0101372A2 (hu) 2001-10-28
EP0945447A1 (de) 1999-09-29
DE69925256D1 (de) 2005-06-16
SI1066269T1 (en) 2005-10-31
TW570917B (en) 2004-01-11
HUP0101372A3 (en) 2003-02-28
ZA200006042B (en) 2001-10-26
EA200000993A1 (ru) 2001-04-23
US6372729B1 (en) 2002-04-16

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090324