HK1002359A1 - Iodinated x-ray contrast media - Google Patents

Iodinated x-ray contrast media

Info

Publication number
HK1002359A1
HK1002359A1 HK98100091A HK98100091A HK1002359A1 HK 1002359 A1 HK1002359 A1 HK 1002359A1 HK 98100091 A HK98100091 A HK 98100091A HK 98100091 A HK98100091 A HK 98100091A HK 1002359 A1 HK1002359 A1 HK 1002359A1
Authority
HK
Hong Kong
Prior art keywords
group
moiety
present
ray contrast
hydroxymethyl
Prior art date
Application number
HK98100091A
Other languages
English (en)
Inventor
Torsten Almen
Sven Andersson
Klaes Golman
Oyvind Antonsen
Rune Fossheim
Unni Nordby Wiggen
Hakan Wikstrom
Tomas Klingstedt
Ib Leunbach
Arne Berg
Harald Dugstad
Lars-Goran Wistrand
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of HK1002359A1 publication Critical patent/HK1002359A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Liquid Crystal (AREA)
HK98100091A 1994-09-23 1998-01-06 Iodinated x-ray contrast media HK1002359A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9419203A GB9419203D0 (en) 1994-09-23 1994-09-23 Contrast media
PCT/GB1995/002265 WO1996009282A1 (en) 1994-09-23 1995-09-22 Iodinated x-ray contrast media

Publications (1)

Publication Number Publication Date
HK1002359A1 true HK1002359A1 (en) 1998-08-21

Family

ID=10761798

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98100091A HK1002359A1 (en) 1994-09-23 1998-01-06 Iodinated x-ray contrast media

Country Status (24)

Country Link
US (2) US5882628A (zh)
EP (1) EP0782564B1 (zh)
JP (1) JP3591840B2 (zh)
CN (1) CN1069633C (zh)
AT (1) ATE183998T1 (zh)
AU (1) AU710330B2 (zh)
CA (1) CA2200753A1 (zh)
CZ (1) CZ89597A3 (zh)
DE (1) DE69511883T2 (zh)
DK (1) DK0782564T3 (zh)
EE (1) EE03350B1 (zh)
ES (1) ES2137541T3 (zh)
FI (1) FI971201A (zh)
GB (1) GB9419203D0 (zh)
GR (1) GR3031712T3 (zh)
HK (1) HK1002359A1 (zh)
HU (1) HUT76894A (zh)
MX (1) MX9702082A (zh)
NO (1) NO971319L (zh)
NZ (1) NZ292975A (zh)
PL (1) PL180863B1 (zh)
RU (1) RU2145955C1 (zh)
SK (1) SK35697A3 (zh)
WO (1) WO1996009282A1 (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB9828103D0 (en) * 1998-12-18 1999-02-17 Nycomed Imaging As Process
ES2243263T3 (es) * 1999-04-30 2005-12-01 Amersham Health As Medios de contraste.
US6685733B1 (en) * 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
DE10332552B3 (de) * 2003-07-14 2005-03-24 Schering Ag Verfahren zur Herstellung von Triiodtrimesinsäure
US7166740B2 (en) 2003-07-14 2007-01-23 Schering Ag Process for the production of triiodotrimesic acid
DE10332574B3 (de) * 2003-07-14 2005-04-14 Schering Ag Verfahren zur Herstellung von Triiodtrimesinsäure
US7083516B2 (en) 2003-07-14 2006-08-01 Schering Ag Process for the production of triiodotrimesic acid
US20060115437A1 (en) * 2004-11-26 2006-06-01 Robert Hayman Dental whitening compositions
US20080050408A1 (en) * 2004-11-26 2008-02-28 Discus Dental, Llc Dental Whitening Compositions
EP2016046B1 (en) * 2006-05-11 2012-07-11 Ge Healthcare As Contrast agents
CA2692646C (en) * 2007-07-12 2014-09-09 Mikkel Thaning Contrast agents
WO2009106552A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2009106551A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
KR101704332B1 (ko) * 2008-06-17 2017-02-07 닛산 가가쿠 고교 가부시키 가이샤 액정 배향 처리제 및 그것을 사용한 액정 표시 소자, 그리고 신규한 디아민
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
PL2493511T3 (pl) * 2009-10-29 2014-05-30 Ge Healthcare As Kompozycja diagnostyczna zawierająca kationy osocza i mająca doskonały profil bezpieczeństwa
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
AU2013208955B2 (en) * 2012-01-11 2017-11-16 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and X-ray imaging process
CN104768921A (zh) * 2012-11-12 2015-07-08 通用电气医疗集团股份有限公司 X-射线造影剂中间体的制备
CN103274910B (zh) * 2013-05-27 2015-03-18 陕西师范大学 一种合成均苯三甲醛类化合物的方法
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
CN108191695B (zh) * 2017-12-08 2019-03-08 牡丹江医学院 一种用于ct的新型造影剂
WO2024214321A1 (ja) * 2023-04-10 2024-10-17 三菱瓦斯化学株式会社 化合物、組成物、増感効果を発現する方法および製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
CH576255A5 (zh) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
US4314055A (en) * 1975-09-29 1982-02-02 Mallinckrodt, Inc. 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
IE63232B1 (en) * 1987-05-22 1995-04-05 Bracco Int Bv A process for the preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
WO1993010078A1 (es) * 1991-11-18 1993-05-27 Centro Investigacion Justesa Imagen S.A. Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5308607A (en) * 1993-02-04 1994-05-03 Sterling Winthrop Inc. Compositions of alkylbenzenes for visualization of the gastrointestinal tract using X-ray contrast
JPH09505813A (ja) * 1993-12-03 1997-06-10 ブラッコ エッセ．ピ．ア． ビフェニル沃素化誘導体及びその診断用途
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico

Also Published As

Publication number Publication date
US5882628A (en) 1999-03-16
MX9702082A (es) 1997-06-28
NZ292975A (en) 1999-02-25
DE69511883D1 (de) 1999-10-07
PL180863B1 (pl) 2001-04-30
EE03350B1 (et) 2001-02-15
CA2200753A1 (en) 1996-03-28
NO971319L (no) 1997-08-11
AU3529495A (en) 1996-04-09
CN1166826A (zh) 1997-12-03
NO971319D0 (no) 1997-03-20
SK35697A3 (en) 1997-11-05
FI971201A0 (fi) 1997-03-21
ES2137541T3 (es) 1999-12-16
CZ89597A3 (en) 1997-10-15
RU2145955C1 (ru) 2000-02-27
WO1996009282A1 (en) 1996-03-28
PL319341A1 (en) 1997-08-04
DE69511883T2 (de) 2000-02-24
FI971201A (fi) 1997-03-21
JP3591840B2 (ja) 2004-11-24
AU710330B2 (en) 1999-09-16
CN1069633C (zh) 2001-08-15
GR3031712T3 (en) 2000-02-29
GB9419203D0 (en) 1994-11-09
DK0782564T3 (da) 1999-12-13
ATE183998T1 (de) 1999-09-15
US5993780A (en) 1999-11-30
JPH10505857A (ja) 1998-06-09
HUT76894A (en) 1997-12-29
EP0782564A1 (en) 1997-07-09
EP0782564B1 (en) 1999-09-01

Similar Documents

Publication Publication Date Title
GB9419203D0 (en) Contrast media
RU97106329A (ru) Иодированные рентгеноконтрастные средства
FI925828A0 (fi) Polyalkylenglykoler foersedda med aendgrupper
CA2073567A1 (en) Spicamycin derivatives and the use thereof
AU4588100A (en) Contrast media
FR2391492A1 (fr) Matieres photopolymerisables ameliorees pour la fabrication de cliches et de formes en relief
EE9700054A (et) Jodeeritud röntgenkontrastaine
KR960001088A (ko) 액정 조성물 및 액정 표시 장치
DK606286A (da) Anthracyclin-derivater og laegemidler indeholdende disse forbindelser
WO2004071376A3 (en) Oral care composition comprising an antimicrobial agent

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040922