HK1002005A1 - Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes - Google Patents

Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Info

Publication number
HK1002005A1
HK1002005A1 HK98100740A HK98100740A HK1002005A1 HK 1002005 A1 HK1002005 A1 HK 1002005A1 HK 98100740 A HK98100740 A HK 98100740A HK 98100740 A HK98100740 A HK 98100740A HK 1002005 A1 HK1002005 A1 HK 1002005A1
Authority
HK
Hong Kong
Prior art keywords
taxanes
sidechain
lactams
preparation
beta
Prior art date
Application number
HK98100740A
Other languages
English (en)
Inventor
John K Thottathil
Ivan D Trifunovich
David J Kucera
Wen Sen Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HK1002005A1 publication Critical patent/HK1002005A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
HK98100740A 1993-03-19 1998-01-27 Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes HK1002005A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19

Publications (1)

Publication Number Publication Date
HK1002005A1 true HK1002005A1 (en) 1998-07-24

Family

ID=21871323

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98100740A HK1002005A1 (en) 1993-03-19 1998-01-27 Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Country Status (18)

Country Link
US (5) US6350886B1 (zh)
EP (2) EP1361222A1 (zh)
JP (1) JPH06321896A (zh)
KR (1) KR100309973B1 (zh)
CN (2) CN1080256C (zh)
AT (1) ATE251134T1 (zh)
CA (1) CA2116093A1 (zh)
CY (1) CY2405B1 (zh)
DE (1) DE69433188T2 (zh)
DK (1) DK0617018T3 (zh)
ES (1) ES2208649T3 (zh)
FI (1) FI941286A (zh)
HK (1) HK1002005A1 (zh)
HU (1) HUT69733A (zh)
IL (3) IL123063A (zh)
PT (1) PT617018E (zh)
SG (1) SG50463A1 (zh)
TW (1) TW467896B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
DE19703549C1 (de) * 1997-01-31 1999-03-04 Clariant Gmbh Verfahren zur Herstellung von Diacylimiden
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
CA2373819A1 (en) 1999-05-17 2000-11-23 Bristol-Myers Squibb Company Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
KR20070013300A (ko) * 2004-05-14 2007-01-30 이뮤노젠 아이엔씨 박카틴 ⅲ 화합물의 합성 방법
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
WO2009137084A2 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
JP5588983B2 (ja) 2008-08-11 2014-09-10 ウェルズ ファーゴ バンク ナショナル アソシエイション マルチアームポリマーアルカノエートコンジュゲート
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2023645C (fr) 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
CA2098478C (en) * 1991-09-23 1999-09-14 Robert A. Holton Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
US7176326B2 (en) 2007-02-13
CY2405B1 (en) 2004-09-10
EP0617018B1 (en) 2003-10-01
DK0617018T3 (da) 2004-01-26
FI941286A0 (fi) 1994-03-18
JPH06321896A (ja) 1994-11-22
SG50463A1 (en) 1998-07-20
IL108763A (en) 1998-07-15
HU9400803D0 (en) 1994-06-28
IL123063A0 (en) 1998-09-24
US6350887B1 (en) 2002-02-26
IL108763A0 (en) 1994-06-24
US20050107605A1 (en) 2005-05-19
AU5791994A (en) 1994-09-22
DE69433188T2 (de) 2004-07-29
HUT69733A (en) 1995-09-28
KR100309973B1 (ko) 2002-02-28
CA2116093A1 (en) 1994-09-20
US20020137927A1 (en) 2002-09-26
US6310201B1 (en) 2001-10-30
CN1080256C (zh) 2002-03-06
US6350886B1 (en) 2002-02-26
EP0617018A1 (en) 1994-09-28
ATE251134T1 (de) 2003-10-15
AU676879B2 (en) 1997-03-27
EP1361222A1 (en) 2003-11-12
TW467896B (en) 2001-12-11
FI941286A (fi) 1994-09-20
IL123063A (en) 2000-02-17
CN1271729A (zh) 2000-11-01
CN1097416A (zh) 1995-01-18
ES2208649T3 (es) 2004-06-16
PT617018E (pt) 2004-02-27
KR940021522A (ko) 1994-10-19
DE69433188D1 (de) 2003-11-06

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080314