GT200400086A - Inhibidores de la pde9 para tratar la diabetes tipo 2, sindrome metabolico y enfermedad cardiovascular - Google Patents

Inhibidores de la pde9 para tratar la diabetes tipo 2, sindrome metabolico y enfermedad cardiovascular

Info

Publication number
GT200400086A
GT200400086A GT200400086A GT200400086A GT200400086A GT 200400086 A GT200400086 A GT 200400086A GT 200400086 A GT200400086 A GT 200400086A GT 200400086 A GT200400086 A GT 200400086A GT 200400086 A GT200400086 A GT 200400086A
Authority
GT
Guatemala
Prior art keywords
diabetes
cardiovascular disease
metabolic syndrome
treat type
pde9 inhibitors
Prior art date
Application number
GT200400086A
Other languages
English (en)
Inventor
Andrew Simon Bell
Michael Paul Deninno
Michael John Palmer
Michael Scott Visser
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of GT200400086A publication Critical patent/GT200400086A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN LA QUE P,A,J,R10,X, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS VAN A INHIBIR A LA FOSFODIESTERASA TIPO 9 (PDE9) DISMINUYENDO LA HIDROLISIS DE LOS NUCLEOTIDOS GMPC Y AMPC Y QUE SON FUNDAMENTALES PARA EL CONTROL Y REGULACION DE UNA MULTITUD DE ACONTECIMIENTOS CELULARES Y POR TODO LO ANTERIOR SON DE UTILIDAD EN UNA AMPLIA VARIEDAD DE PATOLOGIAS TALES COMO DIABETES.
GT200400086A 2003-04-30 2004-04-29 Inhibidores de la pde9 para tratar la diabetes tipo 2, sindrome metabolico y enfermedad cardiovascular GT200400086A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46663903P 2003-04-30 2003-04-30

Publications (1)

Publication Number Publication Date
GT200400086A true GT200400086A (es) 2005-01-11

Family

ID=33551403

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200400086A GT200400086A (es) 2003-04-30 2004-04-29 Inhibidores de la pde9 para tratar la diabetes tipo 2, sindrome metabolico y enfermedad cardiovascular

Country Status (8)

Country Link
AR (1) AR044119A1 (es)
CL (1) CL2004000901A1 (es)
GT (1) GT200400086A (es)
NL (1) NL1026091C2 (es)
PA (1) PA8601601A1 (es)
PE (1) PE20050466A1 (es)
TW (1) TW200503714A (es)
UY (1) UY28291A1 (es)

Also Published As

Publication number Publication date
PE20050466A1 (es) 2005-06-18
PA8601601A1 (es) 2005-02-04
UY28291A1 (es) 2004-11-30
NL1026091C2 (nl) 2005-05-26
CL2004000901A1 (es) 2005-03-18
AR044119A1 (es) 2005-08-24
TW200503714A (en) 2005-02-01
NL1026091A1 (nl) 2004-11-02

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