GR1008330B - Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume - Google Patents
Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volumeInfo
- Publication number
- GR1008330B GR1008330B GR20130100599A GR20130100599A GR1008330B GR 1008330 B GR1008330 B GR 1008330B GR 20130100599 A GR20130100599 A GR 20130100599A GR 20130100599 A GR20130100599 A GR 20130100599A GR 1008330 B GR1008330 B GR 1008330B
- Authority
- GR
- Greece
- Prior art keywords
- drop volume
- pharmaceutical compositions
- physical characteristics
- improved physical
- ophthalmic administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Abstract
The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20130100599A GR1008330B (en) | 2013-10-17 | 2013-10-17 | Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20130100599A GR1008330B (en) | 2013-10-17 | 2013-10-17 | Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1008330B true GR1008330B (en) | 2014-10-20 |
Family
ID=50486917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20130100599A GR1008330B (en) | 2013-10-17 | 2013-10-17 | Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1008330B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR1008921B (en) * | 2015-12-10 | 2017-01-12 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | A preservative-free formulation containing sodium phosphate dexamethasone for occular administration |
GR1009006B (en) * | 2016-04-01 | 2017-04-04 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Preservative free pharmaceutical composition for ophthalmic administration containing bimatoprost and timolol |
GR1009040B (en) * | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Preservative free pharmaceutical ophthalmic compositions |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0431885A1 (en) * | 1989-12-08 | 1991-06-12 | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET | A dropper tip for dispensing a liquid, in particular eye drops |
US20040140319A1 (en) * | 2003-01-22 | 2004-07-22 | Allergan, Inc. | Controlled drop dispensing container |
WO2007056131A2 (en) * | 2005-11-03 | 2007-05-18 | Reseal International Limited Partnership | Continuously sealing one way valve assembly and fluid delivery system formulations for use therein |
US20100210720A1 (en) * | 2007-07-20 | 2010-08-19 | Laboratoires Thea | Preservative-free prostaglandin-based ophthalmic solution |
US20110118349A1 (en) * | 2009-11-19 | 2011-05-19 | Novagali Pharma S.A. | Use of prostaglandins f2alpha and analogues for the healing of corneal and conjunctival lesions |
WO2011126569A1 (en) * | 2010-04-06 | 2011-10-13 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
US20110319487A1 (en) * | 2010-06-29 | 2011-12-29 | Laboratoires Thea | Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives |
WO2012016000A2 (en) * | 2010-07-29 | 2012-02-02 | Allergan, Inc. | Preservative free brimonidine and timolol solutions |
WO2012015996A2 (en) * | 2010-07-29 | 2012-02-02 | Allergan, Inc. | Preservative free bimatoprost solutions |
WO2012163827A2 (en) * | 2011-05-27 | 2012-12-06 | Ratiopharm Gmbh | Ophthalmic preparation comprising a pgf2alpha analogue |
US20120312840A1 (en) * | 2011-05-13 | 2012-12-13 | Ayako Hasegawa | Container closure system with integral antimicrobial additives |
-
2013
- 2013-10-17 GR GR20130100599A patent/GR1008330B/en active IP Right Grant
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0431885A1 (en) * | 1989-12-08 | 1991-06-12 | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET | A dropper tip for dispensing a liquid, in particular eye drops |
US20040140319A1 (en) * | 2003-01-22 | 2004-07-22 | Allergan, Inc. | Controlled drop dispensing container |
WO2007056131A2 (en) * | 2005-11-03 | 2007-05-18 | Reseal International Limited Partnership | Continuously sealing one way valve assembly and fluid delivery system formulations for use therein |
US20100210720A1 (en) * | 2007-07-20 | 2010-08-19 | Laboratoires Thea | Preservative-free prostaglandin-based ophthalmic solution |
US20110118349A1 (en) * | 2009-11-19 | 2011-05-19 | Novagali Pharma S.A. | Use of prostaglandins f2alpha and analogues for the healing of corneal and conjunctival lesions |
WO2011126569A1 (en) * | 2010-04-06 | 2011-10-13 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
US20110319487A1 (en) * | 2010-06-29 | 2011-12-29 | Laboratoires Thea | Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives |
WO2012016000A2 (en) * | 2010-07-29 | 2012-02-02 | Allergan, Inc. | Preservative free brimonidine and timolol solutions |
WO2012015996A2 (en) * | 2010-07-29 | 2012-02-02 | Allergan, Inc. | Preservative free bimatoprost solutions |
US20120312840A1 (en) * | 2011-05-13 | 2012-12-13 | Ayako Hasegawa | Container closure system with integral antimicrobial additives |
WO2012163827A2 (en) * | 2011-05-27 | 2012-12-06 | Ratiopharm Gmbh | Ophthalmic preparation comprising a pgf2alpha analogue |
Non-Patent Citations (9)
Title |
---|
BROWN R H ET AL: "Creating smaller eyedrops by reducing eyedropper tip dimensions", AMERICAN JOURNAL OF OPHTHALMOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 99, no. 4, 1 April 1985 (1985-04-01), pages 460 - 464, XP008170247, ISSN: 0002-9394 * |
GABISSON P ET AL: "Maniabilite et acceptabilite du flacon Abak(R) nouvelle generation chez des patients traites au long cours. Etude transversale, retrospective et multicentrique", ANNALES PHARMACEUTIQUES FRANCAISES, MASSON, PARIS, FR, vol. 69, no. 1, 1 January 2011 (2011-01-01), pages 22 - 29, XP008170294, ISSN: 0003-4509, DOI: 10.1016/J.PHARMA.2010.10.001 * |
LALUEZA BROTO M P ET AL: "Determination of drop size in timolol eye drops", FARMACIA CLINICA, vol. 6, no. 2, March 1989 (1989-03-01), pages 144 - 150, XP008170246 * |
LUC VAN SANTVLIET ET AL: "Determinants of Eye Drop Size", SURVEY OF OPHTHALMOLOGY, vol. 49, no. 2, March 2004 (2004-03-01) - April 2004 (2004-04-01), pages 197 - 213, XP002726654 * |
MONTORO J B ET AL: "Drop size and systemic adverse effects in timolol ophthalmic solution", DICP, THE ANNALS OF PHARMACOTHERAPY, HARVEY WHITNEY BOOKS, CINCINNATI, OH, US, vol. 24, no. 4, 1 April 1990 (1990-04-01), pages 439 - 440, XP008170235, ISSN: 1042-9611, DOI: 10.1177/106002809002400421 * |
VAN SANTVLIET L ET AL: "Dispensing eye drops from flexible plastic dropper bottles. Part I: Influence of the packaging characteristics = Dosierung von Augentropfen aus flexiblen Plastik-Tropfflaschen / Teil 1: Einfluss der Characteristik der Verpackung", PHARMAZEUTISCHE INDUSTRIE, AULENDORF, DE, vol. 61, no. 1, 1 January 1999 (1999-01-01), pages 92 - 96, XP008170231, ISSN: 0031-711X * |
VAN SANTVLIET L ET AL: "Dispensing eye drops from flexible plastic dropper bottles: Part II: Influence of the physico-chemical properties of the formulation and the manipulation technique by the patient", PHARMAZEUTISCHE INDUSTRIE, AULENDORF, DE, vol. 61, no. 2, 1 January 1999 (1999-01-01), pages 194 - 198, XP008170232, ISSN: 0031-711X * |
VAN SANTVLIET L ET AL: "The influence of penetration enhancers on the volume instilled of eye drops", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 45, no. 2, 1 March 1998 (1998-03-01), pages 189 - 198, XP004256969, ISSN: 0939-6411, DOI: 10.1016/S0939-6411(97)00114-8 * |
ZAID N MAMMO ET AL: "Generic versus brand-name North American topical glaucoma drops", CAN J OPHTHALMOL, vol. 47, no. 1, February 2012 (2012-02-01), pages 55 - 61, XP002726653 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR1008921B (en) * | 2015-12-10 | 2017-01-12 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | A preservative-free formulation containing sodium phosphate dexamethasone for occular administration |
GR1009006B (en) * | 2016-04-01 | 2017-04-04 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Preservative free pharmaceutical composition for ophthalmic administration containing bimatoprost and timolol |
GR1009040B (en) * | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Preservative free pharmaceutical ophthalmic compositions |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PG | Patent granted |
Effective date: 20141121 |