GR1008330B - Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume - Google Patents

Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume

Info

Publication number
GR1008330B
GR1008330B GR20130100599A GR20130100599A GR1008330B GR 1008330 B GR1008330 B GR 1008330B GR 20130100599 A GR20130100599 A GR 20130100599A GR 20130100599 A GR20130100599 A GR 20130100599A GR 1008330 B GR1008330 B GR 1008330B
Authority
GR
Greece
Prior art keywords
drop volume
pharmaceutical compositions
physical characteristics
improved physical
ophthalmic administration
Prior art date
Application number
GR20130100599A
Other languages
Greek (el)
Inventor
Ευαγγελος Ανδρεα Καραβας
Ευθυμιος Χρηστου Κουτρης
Ιωαννα Χρηστου Κουτρη
Αναστασια Λεωνιδα Καλασκανη
Βασιλικη Χρηστου Σαμαρα
Ανδρεας Κωνσταντινου Κακουρης
Γεωργιος Θεμιστοκλη Γκοτζαμανης
Original Assignee
"Φαρματεν Α.Β.Ε.Ε.",
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Φαρματεν Α.Β.Ε.Ε.", filed Critical "Φαρματεν Α.Β.Ε.Ε.",
Priority to GR20130100599A priority Critical patent/GR1008330B/en
Publication of GR1008330B publication Critical patent/GR1008330B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Abstract

The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.
GR20130100599A 2013-10-17 2013-10-17 Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume GR1008330B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20130100599A GR1008330B (en) 2013-10-17 2013-10-17 Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20130100599A GR1008330B (en) 2013-10-17 2013-10-17 Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume

Publications (1)

Publication Number Publication Date
GR1008330B true GR1008330B (en) 2014-10-20

Family

ID=50486917

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20130100599A GR1008330B (en) 2013-10-17 2013-10-17 Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume

Country Status (1)

Country Link
GR (1) GR1008330B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1008921B (en) * 2015-12-10 2017-01-12 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων A preservative-free formulation containing sodium phosphate dexamethasone for occular administration
GR1009006B (en) * 2016-04-01 2017-04-04 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Preservative free pharmaceutical composition for ophthalmic administration containing bimatoprost and timolol
GR1009040B (en) * 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Preservative free pharmaceutical ophthalmic compositions

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431885A1 (en) * 1989-12-08 1991-06-12 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET A dropper tip for dispensing a liquid, in particular eye drops
US20040140319A1 (en) * 2003-01-22 2004-07-22 Allergan, Inc. Controlled drop dispensing container
WO2007056131A2 (en) * 2005-11-03 2007-05-18 Reseal International Limited Partnership Continuously sealing one way valve assembly and fluid delivery system formulations for use therein
US20100210720A1 (en) * 2007-07-20 2010-08-19 Laboratoires Thea Preservative-free prostaglandin-based ophthalmic solution
US20110118349A1 (en) * 2009-11-19 2011-05-19 Novagali Pharma S.A. Use of prostaglandins f2alpha and analogues for the healing of corneal and conjunctival lesions
WO2011126569A1 (en) * 2010-04-06 2011-10-13 Reseal International Limited Partnership Delivery system for dispensing metered volumes of pure or sterile flowable substances
US20110319487A1 (en) * 2010-06-29 2011-12-29 Laboratoires Thea Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives
WO2012016000A2 (en) * 2010-07-29 2012-02-02 Allergan, Inc. Preservative free brimonidine and timolol solutions
WO2012015996A2 (en) * 2010-07-29 2012-02-02 Allergan, Inc. Preservative free bimatoprost solutions
WO2012163827A2 (en) * 2011-05-27 2012-12-06 Ratiopharm Gmbh Ophthalmic preparation comprising a pgf2alpha analogue
US20120312840A1 (en) * 2011-05-13 2012-12-13 Ayako Hasegawa Container closure system with integral antimicrobial additives

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431885A1 (en) * 1989-12-08 1991-06-12 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET A dropper tip for dispensing a liquid, in particular eye drops
US20040140319A1 (en) * 2003-01-22 2004-07-22 Allergan, Inc. Controlled drop dispensing container
WO2007056131A2 (en) * 2005-11-03 2007-05-18 Reseal International Limited Partnership Continuously sealing one way valve assembly and fluid delivery system formulations for use therein
US20100210720A1 (en) * 2007-07-20 2010-08-19 Laboratoires Thea Preservative-free prostaglandin-based ophthalmic solution
US20110118349A1 (en) * 2009-11-19 2011-05-19 Novagali Pharma S.A. Use of prostaglandins f2alpha and analogues for the healing of corneal and conjunctival lesions
WO2011126569A1 (en) * 2010-04-06 2011-10-13 Reseal International Limited Partnership Delivery system for dispensing metered volumes of pure or sterile flowable substances
US20110319487A1 (en) * 2010-06-29 2011-12-29 Laboratoires Thea Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives
WO2012016000A2 (en) * 2010-07-29 2012-02-02 Allergan, Inc. Preservative free brimonidine and timolol solutions
WO2012015996A2 (en) * 2010-07-29 2012-02-02 Allergan, Inc. Preservative free bimatoprost solutions
US20120312840A1 (en) * 2011-05-13 2012-12-13 Ayako Hasegawa Container closure system with integral antimicrobial additives
WO2012163827A2 (en) * 2011-05-27 2012-12-06 Ratiopharm Gmbh Ophthalmic preparation comprising a pgf2alpha analogue

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BROWN R H ET AL: "Creating smaller eyedrops by reducing eyedropper tip dimensions", AMERICAN JOURNAL OF OPHTHALMOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 99, no. 4, 1 April 1985 (1985-04-01), pages 460 - 464, XP008170247, ISSN: 0002-9394 *
GABISSON P ET AL: "Maniabilite et acceptabilite du flacon Abak(R) nouvelle generation chez des patients traites au long cours. Etude transversale, retrospective et multicentrique", ANNALES PHARMACEUTIQUES FRANCAISES, MASSON, PARIS, FR, vol. 69, no. 1, 1 January 2011 (2011-01-01), pages 22 - 29, XP008170294, ISSN: 0003-4509, DOI: 10.1016/J.PHARMA.2010.10.001 *
LALUEZA BROTO M P ET AL: "Determination of drop size in timolol eye drops", FARMACIA CLINICA, vol. 6, no. 2, March 1989 (1989-03-01), pages 144 - 150, XP008170246 *
LUC VAN SANTVLIET ET AL: "Determinants of Eye Drop Size", SURVEY OF OPHTHALMOLOGY, vol. 49, no. 2, March 2004 (2004-03-01) - April 2004 (2004-04-01), pages 197 - 213, XP002726654 *
MONTORO J B ET AL: "Drop size and systemic adverse effects in timolol ophthalmic solution", DICP, THE ANNALS OF PHARMACOTHERAPY, HARVEY WHITNEY BOOKS, CINCINNATI, OH, US, vol. 24, no. 4, 1 April 1990 (1990-04-01), pages 439 - 440, XP008170235, ISSN: 1042-9611, DOI: 10.1177/106002809002400421 *
VAN SANTVLIET L ET AL: "Dispensing eye drops from flexible plastic dropper bottles. Part I: Influence of the packaging characteristics = Dosierung von Augentropfen aus flexiblen Plastik-Tropfflaschen / Teil 1: Einfluss der Characteristik der Verpackung", PHARMAZEUTISCHE INDUSTRIE, AULENDORF, DE, vol. 61, no. 1, 1 January 1999 (1999-01-01), pages 92 - 96, XP008170231, ISSN: 0031-711X *
VAN SANTVLIET L ET AL: "Dispensing eye drops from flexible plastic dropper bottles: Part II: Influence of the physico-chemical properties of the formulation and the manipulation technique by the patient", PHARMAZEUTISCHE INDUSTRIE, AULENDORF, DE, vol. 61, no. 2, 1 January 1999 (1999-01-01), pages 194 - 198, XP008170232, ISSN: 0031-711X *
VAN SANTVLIET L ET AL: "The influence of penetration enhancers on the volume instilled of eye drops", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 45, no. 2, 1 March 1998 (1998-03-01), pages 189 - 198, XP004256969, ISSN: 0939-6411, DOI: 10.1016/S0939-6411(97)00114-8 *
ZAID N MAMMO ET AL: "Generic versus brand-name North American topical glaucoma drops", CAN J OPHTHALMOL, vol. 47, no. 1, February 2012 (2012-02-01), pages 55 - 61, XP002726653 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1008921B (en) * 2015-12-10 2017-01-12 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων A preservative-free formulation containing sodium phosphate dexamethasone for occular administration
GR1009006B (en) * 2016-04-01 2017-04-04 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Preservative free pharmaceutical composition for ophthalmic administration containing bimatoprost and timolol
GR1009040B (en) * 2016-04-19 2017-05-19 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Preservative free pharmaceutical ophthalmic compositions

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PG Patent granted

Effective date: 20141121