GB959261A - Ergoline i derivatives - Google Patents
Ergoline i derivativesInfo
- Publication number
- GB959261A GB959261A GB1998762A GB1998762A GB959261A GB 959261 A GB959261 A GB 959261A GB 1998762 A GB1998762 A GB 1998762A GB 1998762 A GB1998762 A GB 1998762A GB 959261 A GB959261 A GB 959261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- cycloaliphatic
- methyl
- hydrogen
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1
- -1 cycloaliphatic Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- VZMIIYFDQQAANA-PXFYRTPJSA-N [(6ar,10ar)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methanamine Chemical compound C1=CC([C@H]2CC(CN)CN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 VZMIIYFDQQAANA-PXFYRTPJSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000002908 adrenolytic effect Effects 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 230000002196 ecbolic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT980861 | 1961-05-29 | ||
| IT1617861 | 1961-09-07 | ||
| IT85562A IT1051702B (it) | 1962-01-18 | 1962-01-18 | Perfezionamenti relativi a derivati della 6 metil e della 1.6 dimetil ergolina 1 |
| IT1570063A IT1051709B (it) | 1963-07-26 | 1963-07-26 | Perfezionamenti relativi a derivati della 1.6 dimetil ergolina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB959261A true GB959261A (en) | 1964-05-27 |
Family
ID=27452643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1998762A Expired GB959261A (en) | 1961-05-29 | 1962-05-24 | Ergoline i derivatives |
| GB3069464A Expired GB1004310A (en) | 1961-05-29 | 1964-08-04 | 1,6-dimethyl-ergoline i derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3069464A Expired GB1004310A (en) | 1961-05-29 | 1964-08-04 | 1,6-dimethyl-ergoline i derivatives |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE650930A (forum.php) |
| BR (2) | BR6239435D0 (forum.php) |
| CH (1) | CH430737A (forum.php) |
| DE (2) | DE1470217A1 (forum.php) |
| FI (2) | FI45660C (forum.php) |
| FR (3) | FR1326772A (forum.php) |
| GB (2) | GB959261A (forum.php) |
| NL (3) | NL6408237A (forum.php) |
| NO (1) | NO118975B (forum.php) |
| SE (2) | SE315903B (forum.php) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299836A (en) * | 1979-07-12 | 1981-11-10 | Richter Gedeon Vegyeszeti Gyar Rt. | Novel ergol-8-ene and ergolin compounds and process for preparing same |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
| US4766128A (en) * | 1983-03-14 | 1988-08-23 | Schering Aktiengesellschaft | Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents |
| EP0411494A3 (en) * | 1989-08-04 | 1991-04-24 | Poli Industria Chimica S.P.A. | Ergoline derivatives having dopaminergic activity |
| US7572883B2 (en) | 2001-06-08 | 2009-08-11 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
| US8952128B2 (en) | 2012-11-01 | 2015-02-10 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1513322A (en) * | 1976-01-09 | 1978-06-07 | Farmaceutici Italia | Heterocyclic ergoline derivatives |
-
0
- NL NL278401D patent/NL278401A/xx unknown
- NL NL128196D patent/NL128196C/xx active
- FR FR98D patent/FR98F/fr active Active
-
1962
- 1962-05-23 DE DE19621470217 patent/DE1470217A1/de not_active Withdrawn
- 1962-05-24 FI FI104462A patent/FI45660C/fi active
- 1962-05-24 GB GB1998762A patent/GB959261A/en not_active Expired
- 1962-05-24 CH CH628462A patent/CH430737A/de unknown
- 1962-05-25 FR FR898776A patent/FR1326772A/fr not_active Expired
- 1962-05-28 BR BR13943562A patent/BR6239435D0/pt unknown
- 1962-05-28 FR FR898966A patent/FR2075M/fr not_active Expired
- 1962-05-28 SE SE597162A patent/SE315903B/xx unknown
-
1964
- 1964-07-17 NL NL6408237A patent/NL6408237A/xx unknown
- 1964-07-21 SE SE884364A patent/SE324784B/xx unknown
- 1964-07-21 FI FI156364A patent/FI46507C/fi active
- 1964-07-22 BR BR16103964A patent/BR6461039D0/pt unknown
- 1964-07-22 DE DE19641470285 patent/DE1470285A1/de not_active Withdrawn
- 1964-07-23 NO NO15411664A patent/NO118975B/no unknown
- 1964-07-24 BE BE650930A patent/BE650930A/xx unknown
- 1964-08-04 GB GB3069464A patent/GB1004310A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299836A (en) * | 1979-07-12 | 1981-11-10 | Richter Gedeon Vegyeszeti Gyar Rt. | Novel ergol-8-ene and ergolin compounds and process for preparing same |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
| US4766128A (en) * | 1983-03-14 | 1988-08-23 | Schering Aktiengesellschaft | Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents |
| EP0411494A3 (en) * | 1989-08-04 | 1991-04-24 | Poli Industria Chimica S.P.A. | Ergoline derivatives having dopaminergic activity |
| US7572883B2 (en) | 2001-06-08 | 2009-08-11 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
| US7579435B2 (en) | 2001-06-08 | 2009-08-25 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
| US8178651B2 (en) | 2001-06-08 | 2012-05-15 | Ipsen Pharma, S.A.S. | Somatostatin-dopamine chimeric analogs |
| US8324386B2 (en) | 2001-06-08 | 2012-12-04 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
| US8952128B2 (en) | 2012-11-01 | 2015-02-10 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
| US9603942B2 (en) | 2012-11-01 | 2017-03-28 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
| US9731027B2 (en) | 2012-11-01 | 2017-08-15 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1470285A1 (de) | 1970-07-02 |
| SE315903B (forum.php) | 1969-10-13 |
| FI45660C (fi) | 1972-08-10 |
| SE324784B (forum.php) | 1970-06-15 |
| CH430737A (de) | 1967-02-28 |
| FI46507C (fi) | 1973-04-10 |
| BE650930A (forum.php) | 1964-11-16 |
| FR2075M (fr) | 1963-10-14 |
| FI46507B (fi) | 1973-01-02 |
| DE1470217A1 (de) | 1969-12-11 |
| FR98F (forum.php) | |
| BR6461039D0 (pt) | 1973-08-14 |
| FR1326772A (forum.php) | 1963-04-01 |
| GB1004310A (en) | 1965-09-15 |
| NL128196C (forum.php) | |
| NL278401A (forum.php) | |
| NO118975B (forum.php) | 1970-03-09 |
| NL6408237A (forum.php) | 1965-01-27 |
| BR6239435D0 (pt) | 1973-06-14 |
| FI45660B (forum.php) | 1972-05-02 |
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