GB946656A - 18:20-oxido-steroids and process for their manufacture - Google Patents
18:20-oxido-steroids and process for their manufactureInfo
- Publication number
- GB946656A GB946656A GB510960A GB510960A GB946656A GB 946656 A GB946656 A GB 946656A GB 510960 A GB510960 A GB 510960A GB 510960 A GB510960 A GB 510960A GB 946656 A GB946656 A GB 946656A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethylenedioxy
- acetoxy
- hydroxy
- pregnene
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000006227 byproduct Substances 0.000 abstract 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 229930194542 Keto Natural products 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- VZRAKVPDZIQRGT-WZBAXQLOSA-N (8r,9s,10s,13r,14s,17r)-17-ethenyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C=C)[C@@H]4[C@@H]3CCC21 VZRAKVPDZIQRGT-WZBAXQLOSA-N 0.000 abstract 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- IWRPVTXREVYBHT-QHXXRISESA-N [(10r,11r,13s,17s)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl] acetate Chemical compound O=C1CC[C@]2(C)C3[C@H](OC(=O)C)C[C@]4(C)[C@@H](C(C)=O)CCC4C3CCC2=C1 IWRPVTXREVYBHT-QHXXRISESA-N 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052796 boron Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 238000005907 ketalization reaction Methods 0.000 abstract 1
- ACKFDYCQCBEDNU-UHFFFAOYSA-J lead(2+);tetraacetate Chemical compound [Pb+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O ACKFDYCQCBEDNU-UHFFFAOYSA-J 0.000 abstract 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 abstract 1
- 150000002978 peroxides Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- KZJPVUDYAMEDRM-UHFFFAOYSA-M silver;2,2,2-trifluoroacetate Chemical compound [Ag+].[O-]C(=O)C(F)(F)F KZJPVUDYAMEDRM-UHFFFAOYSA-M 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6947559A CH383953A (de) | 1959-02-12 | 1959-02-12 | Verfahren zur Herstellung von 18,20-Oxido-steroiden |
| CH7244359 | 1959-04-23 | ||
| CH7375459 | 1959-05-29 | ||
| CH7526059 | 1959-07-03 | ||
| CH8178059A CH407111A (de) | 1959-12-11 | 1959-12-11 | Verfahren zur Herstellung von neuen Hydroxyaldehyden der Pregnanreihe |
| CH8223159 | 1959-12-22 | ||
| CH8223359 | 1959-12-22 | ||
| CH8223459 | 1959-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB946656A true GB946656A (en) | 1964-01-15 |
Family
ID=31721976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3021863A Expired GB946660A (en) | 1959-02-12 | 1960-02-12 | New 18-unsubstituted 20-hydroxy-pregnanes |
| GB510960A Expired GB946656A (en) | 1959-02-12 | 1960-02-12 | 18:20-oxido-steroids and process for their manufacture |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3021863A Expired GB946660A (en) | 1959-02-12 | 1960-02-12 | New 18-unsubstituted 20-hydroxy-pregnanes |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB946660A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
| SE (1) | SE305207B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
-
1960
- 1960-02-12 GB GB3021863A patent/GB946660A/en not_active Expired
- 1960-02-12 GB GB510960A patent/GB946656A/en not_active Expired
- 1960-02-12 SE SE146060A patent/SE305207B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE305207B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-10-21 |
| GB946660A (en) | 1964-01-15 |
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