GB944428A - Cobalamin derivatives - Google Patents

Cobalamin derivatives

Info

Publication number
GB944428A
GB944428A GB1158560A GB1158560A GB944428A GB 944428 A GB944428 A GB 944428A GB 1158560 A GB1158560 A GB 1158560A GB 1158560 A GB1158560 A GB 1158560A GB 944428 A GB944428 A GB 944428A
Authority
GB
United Kingdom
Prior art keywords
acid
amino acid
cobalamin
cobalamins
tryptophane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1158560A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB944428A publication Critical patent/GB944428A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Abstract

The Specification comprises amino acid cobalamins of which those derived from glycine, lysine, aspartic acid, alanine, serine, cysteine, phenylalamine, tryptophane, histidine, methionine, valine, leucine, arginine, glutamic acid, and proline are specified. These compounds may be prepared by intimately contacting hydroxocobalamin and an amino acid in aqueous solution and then adding acetone to precipitate the product in crystelline form, alternatively the aqueous solution is evaporated by freeze drying. The compounds may be mixed with a solid carrier such as lactose, starch, sugar, stearic acid, magnesium stearate or gelatin or with a liquid such as water or benzyl alcohol to give compositions which give high prolonged serum levels on administration.ALSO:A medicinal preparation comprises an amino acid cobalamin and a pharmacologically acceptable carrier therefor. Specified cobalamins are those derived from glycine, lysine, aspartic acid, alanine, serine, cysteine, phenylalanine, tryptophane, histidine, methionine, valine, leucine, arginine, glutamic acid and proline; and they may be made according to the method described in Division C2. The carrier may be lactose, starch, sugar, stearic acid, magnesium stearate, or gelatin, or a liquid such as water or benzyl alcohol. The compositions may be made up in dosage units of 1 to 2500 mlg. of cobalamin activity.
GB1158560A 1959-04-06 1960-04-01 Cobalamin derivatives Expired GB944428A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80414559A 1959-04-06 1959-04-06

Publications (1)

Publication Number Publication Date
GB944428A true GB944428A (en) 1963-12-11

Family

ID=25188296

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1158560A Expired GB944428A (en) 1959-04-06 1960-04-01 Cobalamin derivatives

Country Status (5)

Country Link
BE (1) BE589207A (en)
CH (1) CH385873A (en)
ES (1) ES257320A1 (en)
GB (1) GB944428A (en)
SE (1) SE304004B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232805B2 (en) 2003-09-10 2007-06-19 Inflabloc Pharmaceuticals, Inc. Cobalamin conjugates for anti-tumor therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232805B2 (en) 2003-09-10 2007-06-19 Inflabloc Pharmaceuticals, Inc. Cobalamin conjugates for anti-tumor therapy

Also Published As

Publication number Publication date
CH385873A (en) 1964-12-31
ES257320A1 (en) 1960-07-01
BE589207A (en) 1960-09-30
SE304004B (en) 1968-09-16

Similar Documents

Publication Publication Date Title
Maenz et al. Methionine and 2-hydroxy-4-methylthiobutanoic acid are transported by distinct Na+-dependent and H+-dependent systems in the brush border membrane of the chick intestinal epithelium
SE7907316L (en) AMINOSYRALOSNING
GB1399888A (en) Injectable amino acid composition
GB1511302A (en) Pharmaceutical compositions comprising amino acid analogues
NO870159L (en) STABILIZED TOKOFEROL IN TURR, LIGHT-FLOWING PARTICLE FORM
US2662046A (en) Parenteral amino acid solution
JPS54147916A (en) Preparation of urokinase injection
Johansson et al. Metabolism of pyridoxine-3H8 in mice
GB1004774A (en) Improvements in or relating to synthetic moisturizing materials
GB1034358A (en) Body-protein-biosynthesis promoting composition
KR840008279A (en) Atomization Method of Amino Acid-Containing Fat Emulsion
GB944428A (en) Cobalamin derivatives
Dann et al. Cycloserine inhibition of gamma-aminobutyric-alpha-ketoglutaric transaminase
Das et al. Substrate specificity of a highly active dipeptidase purified from monkey small intestine.
Dopheide et al. N-Terminal Amino-acids in Purified Hog Thyroglobulin
KR840002657A (en) Process for preparing interferon composition
GB1189935A (en) Dried Stable Anti-Tumour Preparations and a process for preparing the same
GB900115A (en) Improvements in or relating to trypsin solutions
GB955683A (en) Pharmaceutical cobalamin compositions
GB1272606A (en) Imidazolinyl benzalhydrazone and a process for its preparation
HIGASHI et al. Studies on Rat Liver Catalase: III. Amino Acid Composition of Rat Liver Catalase
GB1195381A (en) Pharmaceutical Compositions Comprising Potassium and Chlorine
Risser et al. Intravenous utilization of partial acid hydrolysates of proteins
Friedberg The amino acid composition of adenosine triphosphate-creatine transphosphorylase
Morenkova Incorporation of 35S-methionine into Insulin