GB921301A - Improvements in or relating to phenthiazine derivatives - Google Patents
Improvements in or relating to phenthiazine derivativesInfo
- Publication number
- GB921301A GB921301A GB2368459A GB2368459A GB921301A GB 921301 A GB921301 A GB 921301A GB 2368459 A GB2368459 A GB 2368459A GB 2368459 A GB2368459 A GB 2368459A GB 921301 A GB921301 A GB 921301A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- compound
- acid
- bromophenyl
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0921301/IV(a)/1> (wherein R1 represetns a bromine atom or a methoxy group and R2 a methyl group) and their acid addition salts, the preparation thereof by condensing a compound of the general formula <FORM:0921301/IV(a)/2> with a compound of the general formula <FORM:0921301/IV(a)/3> (wherein Hal represents a chlorine, bromine or iodine atom) and, if desired, salifying the resulting base with an inorganic or organic acid, and pharmaceutical preparations containing the products and an inert carrier. 3-Bromophenthiazine is prepared by condensing m - bromoaniline with potassium o-chlorobenzoate to form N-(3-bromophenyl)-anthranilic acid, decarboxylating this by heating to form N-(3-bromophenyl)-aniline, and heating this with sulphur and iodine. 2-(N-Methylpyrrolidyl-21)-1-chloroethane is prepared by the action of thionyl chloride on the corresponding 1-hydroxy compound in chloroform solution saturated with hydrochloric acid. The pharmaceutical preparations, which have neuroplegic and tranquillizing properties, may take the form of tablets or injectable solutions. Specifications 772,179, 820,134 and 823,733 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH6159158 | 1958-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB921301A true GB921301A (en) | 1963-03-20 |
Family
ID=4523744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2368459A Expired GB921301A (en) | 1958-07-10 | 1959-07-09 | Improvements in or relating to phenthiazine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB921301A (en) |
-
1959
- 1959-07-09 GB GB2368459A patent/GB921301A/en not_active Expired
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