GB920126A - Improvements in or relating to the production of tetracycline - Google Patents

Improvements in or relating to the production of tetracycline

Info

Publication number
GB920126A
GB920126A GB25557/59A GB2555759A GB920126A GB 920126 A GB920126 A GB 920126A GB 25557/59 A GB25557/59 A GB 25557/59A GB 2555759 A GB2555759 A GB 2555759A GB 920126 A GB920126 A GB 920126A
Authority
GB
United Kingdom
Prior art keywords
produce mutant
irradiation
tetracycline
mutant
ray irradiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25557/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB920126A publication Critical patent/GB920126A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Tetracycline and its salts are prepared by culturing a new strain of Streptomyces aureofaciens designated S. aureofaciens NCIB-9114 myces. The new strain is prepared from a chlortetracycline producing strain of S. aureofaciens designated LSZ-536 by the following in conventional nutrient media for Streptosteps (a) UV-irradiation to produce mutant C-241, (b) X-ray irradiation of C-241 to produce mutant D-6, (c) UV-irradiation of D-6 in the presence of benzyl thiocyanate to produce mutant G-993, (d) X-ray irradiation of G-993 and chilling to produce mutant CD-815, (e) treatment of CD-815 with streptomycin to produce mutant CDS-425, (f) incubation of CDS-425 in Coenzyme A supplemented synthetic medium, followed by X-ray irradiation in the presence of KCN to produce mutant CDSD-314 (NCIB-9114). The tetracycline may be recovered in the conventional manner but with a step of treating an aqueous acid extract containing ferric salts e.g. chloride with a borohydride e.g. sodium borohydride and concentrating to precipitate the tetracycline. Reference has been directed by the Comptroller to Specification 747,779.ALSO:A tetracycline-producing strain of Streptomyces aureofaciens (NCIB-9114) is produced from a chlortetracycline-producing strain of S. aureofaciens designated LSZ-536 by the following steps: (a) UV-irradiation to produce mutant mutant C-241; (b) X-ray irradiation of C-241 to produce mutant D-6; (c) UV-irradiation of D-6 in the presence of benzyl thiocyanate to produce mutant G-993; (d) X-ray irradiation of G-993 and chilling to produce mutant CD-815; (e) treatment of CD-816 with streptomycin to produce mutant CDS-425; (f) incubation of CDS-425 in coenzyme A supplemented synthetic medium, followed by X-ray irradiation in the presence of KCN to produce mutant CDSD-314 (NCIB-9114). Reference has been directed by the Comptroller to Specification 747,779.
GB25557/59A 1958-07-24 1959-07-24 Improvements in or relating to the production of tetracycline Expired GB920126A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000280 1958-07-24

Publications (1)

Publication Number Publication Date
GB920126A true GB920126A (en) 1963-03-06

Family

ID=10994292

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25557/59A Expired GB920126A (en) 1958-07-24 1959-07-24 Improvements in or relating to the production of tetracycline

Country Status (2)

Country Link
DK (1) DK113913B (en)
GB (1) GB920126A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432394A (en) * 1967-08-15 1969-03-11 Int Rectifier Corp Fermentative production of tetracycline
US3434930A (en) * 1964-06-26 1969-03-25 Spofa Vereinigte Pharma Werke Method of producing tetracycline

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3434930A (en) * 1964-06-26 1969-03-25 Spofa Vereinigte Pharma Werke Method of producing tetracycline
US3432394A (en) * 1967-08-15 1969-03-11 Int Rectifier Corp Fermentative production of tetracycline

Also Published As

Publication number Publication date
DK113913B (en) 1969-05-12

Similar Documents

Publication Publication Date Title
ES278057A1 (en) Procedure for the preparation of lincomicina (Machine-translation by Google Translate, not legally binding)
GB1009370A (en) A process for the production of 1-glutamic acid by fermentation
ES235737A1 (en) 6-demethyltetracyclines and methods for preparing the same
GB1097908A (en) A fermentation process for the production of l-threonine
GB920126A (en) Improvements in or relating to the production of tetracycline
JPS5639778A (en) Novel modified strain
GB1118719A (en) Process for producing l-lysine by fermentation
ES419433A1 (en) Method of producing L-arginine by fermentation
GB1004725A (en) A process for the preparation of optically active amino acids
GB1161988A (en) A Process for the Production of Inosine
GB1115114A (en) Process for producing inosine
GB1180104A (en) Method of Producing L-Lysine.
GB1385568A (en) Process for producing l-arginine
GB1394849A (en) 5-dihydrocoriolin c and process for producing the same
ES393771A1 (en) Process for the manufacture of zeaxanthin
GB930969A (en) Process for the production of 7-chloro-6-demethyltetracycline
GB912353A (en) Improvements in processes for the production of 1-glutamic acid
GB1170970A (en) Process for Producing Xanthylic Acid by Fermentation.
GB1166896A (en) Process for producing D-Ribulose and D-Xylulose by fermentation
GB1015613A (en) Production of 6-demethylchlortetracyline
GB1076052A (en) Fermentative method for the production of l-glutamic acid
ES406202A1 (en) Antibiotic fr-1923 and a process for the preparation thereof
ES226033A2 (en) A method for obtaining antibiotic substances (Machine-translation by Google Translate, not legally binding)
GB1358769A (en) Process for producing 2-substituted purine ribotides
GB1430842A (en) Method of producing l-lysine by fermentation