GB920126A - Improvements in or relating to the production of tetracycline - Google Patents
Improvements in or relating to the production of tetracyclineInfo
- Publication number
- GB920126A GB920126A GB25557/59A GB2555759A GB920126A GB 920126 A GB920126 A GB 920126A GB 25557/59 A GB25557/59 A GB 25557/59A GB 2555759 A GB2555759 A GB 2555759A GB 920126 A GB920126 A GB 920126A
- Authority
- GB
- United Kingdom
- Prior art keywords
- produce mutant
- irradiation
- tetracycline
- mutant
- ray irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Tetracycline and its salts are prepared by culturing a new strain of Streptomyces aureofaciens designated S. aureofaciens NCIB-9114 myces. The new strain is prepared from a chlortetracycline producing strain of S. aureofaciens designated LSZ-536 by the following in conventional nutrient media for Streptosteps (a) UV-irradiation to produce mutant C-241, (b) X-ray irradiation of C-241 to produce mutant D-6, (c) UV-irradiation of D-6 in the presence of benzyl thiocyanate to produce mutant G-993, (d) X-ray irradiation of G-993 and chilling to produce mutant CD-815, (e) treatment of CD-815 with streptomycin to produce mutant CDS-425, (f) incubation of CDS-425 in Coenzyme A supplemented synthetic medium, followed by X-ray irradiation in the presence of KCN to produce mutant CDSD-314 (NCIB-9114). The tetracycline may be recovered in the conventional manner but with a step of treating an aqueous acid extract containing ferric salts e.g. chloride with a borohydride e.g. sodium borohydride and concentrating to precipitate the tetracycline. Reference has been directed by the Comptroller to Specification 747,779.ALSO:A tetracycline-producing strain of Streptomyces aureofaciens (NCIB-9114) is produced from a chlortetracycline-producing strain of S. aureofaciens designated LSZ-536 by the following steps: (a) UV-irradiation to produce mutant mutant C-241; (b) X-ray irradiation of C-241 to produce mutant D-6; (c) UV-irradiation of D-6 in the presence of benzyl thiocyanate to produce mutant G-993; (d) X-ray irradiation of G-993 and chilling to produce mutant CD-815; (e) treatment of CD-816 with streptomycin to produce mutant CDS-425; (f) incubation of CDS-425 in coenzyme A supplemented synthetic medium, followed by X-ray irradiation in the presence of KCN to produce mutant CDSD-314 (NCIB-9114). Reference has been directed by the Comptroller to Specification 747,779.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUCI000280 | 1958-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB920126A true GB920126A (en) | 1963-03-06 |
Family
ID=10994292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB25557/59A Expired GB920126A (en) | 1958-07-24 | 1959-07-24 | Improvements in or relating to the production of tetracycline |
Country Status (2)
Country | Link |
---|---|
DK (1) | DK113913B (en) |
GB (1) | GB920126A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3432394A (en) * | 1967-08-15 | 1969-03-11 | Int Rectifier Corp | Fermentative production of tetracycline |
US3434930A (en) * | 1964-06-26 | 1969-03-25 | Spofa Vereinigte Pharma Werke | Method of producing tetracycline |
-
1959
- 1959-07-21 DK DK261559AA patent/DK113913B/en unknown
- 1959-07-24 GB GB25557/59A patent/GB920126A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3434930A (en) * | 1964-06-26 | 1969-03-25 | Spofa Vereinigte Pharma Werke | Method of producing tetracycline |
US3432394A (en) * | 1967-08-15 | 1969-03-11 | Int Rectifier Corp | Fermentative production of tetracycline |
Also Published As
Publication number | Publication date |
---|---|
DK113913B (en) | 1969-05-12 |
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