GB914737A - New steroids, their formation and conversion into therapeutically useful substances - Google Patents
New steroids, their formation and conversion into therapeutically useful substancesInfo
- Publication number
- GB914737A GB914737A GB3789060A GB3789060A GB914737A GB 914737 A GB914737 A GB 914737A GB 3789060 A GB3789060 A GB 3789060A GB 3789060 A GB3789060 A GB 3789060A GB 914737 A GB914737 A GB 914737A
- Authority
- GB
- United Kingdom
- Prior art keywords
- keto
- conversion
- formation
- therapeutically useful
- useful substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises a compound of the formula: <FORM:0914737/IV (b)/1> wherein R is H or an acyloxy radical derived from an organic carboxylic acid and a process for the preparation thereof which comprises the step of cyclizing by means of an alkaline condensation agent in an inert solvent, a 6-keto - 7 - (g -keto-butyl)-9a-methyl-3a,3b,4,5,8,9-hexahydro-cyclopentano - [2,1-c] - naphthalene compound of the formula: <FORM:0914737/IV (b)/2> in which R1 represents R above, so as to effect intramolecular condensation between the 6-keto group and the terminal methyl group of the 7-(g -keto-butyl) substituent thereof. Subsequently the products may be isomerised to form estradiol or a 17-acylate thereof. The products may be converted to estradiol or 17-esters thereof by isomerisation in the presence of a hydrogenation catalyst, e.g. palladinised charcoal. Specifications 914,732 and 914,736 are referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR809188A FR1248482A (en) | 1959-11-03 | 1959-11-03 | 19-nor-androstadienic compounds and their preparation process |
| FR809481A FR1248553A (en) | 1959-11-06 | 1959-11-06 | 5-hydroxy 19-nor androstenic derivatives, method of preparation and applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB914737A true GB914737A (en) | 1963-01-02 |
Family
ID=26184567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3788960A Expired GB914736A (en) | 1959-11-03 | 1960-11-03 | New steroids, their formation and conversion into therapeutically valuable substances |
| GB3789060A Expired GB914737A (en) | 1959-11-03 | 1960-11-03 | New steroids, their formation and conversion into therapeutically useful substances |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3788960A Expired GB914736A (en) | 1959-11-03 | 1960-11-03 | New steroids, their formation and conversion into therapeutically valuable substances |
Country Status (1)
| Country | Link |
|---|---|
| GB (2) | GB914736A (en) |
-
1960
- 1960-11-03 GB GB3788960A patent/GB914736A/en not_active Expired
- 1960-11-03 GB GB3789060A patent/GB914737A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB914736A (en) | 1963-01-02 |
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