GB854715A - Process for the manufacture of hydrophilic high molecular weight substances from dextran substances - Google Patents

Process for the manufacture of hydrophilic high molecular weight substances from dextran substances

Info

Publication number
GB854715A
GB854715A GB188359A GB188359A GB854715A GB 854715 A GB854715 A GB 854715A GB 188359 A GB188359 A GB 188359A GB 188359 A GB188359 A GB 188359A GB 854715 A GB854715 A GB 854715A
Authority
GB
United Kingdom
Prior art keywords
dextran
containing
products
substances
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB188359A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SE245258A priority Critical patent/SE169293C1/xx
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of GB854715A publication Critical patent/GB854715A/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16Organic material
    • B01J39/18Macromolecular compounds
    • B01J39/22Cellulose or wood; Derivatives thereof

Abstract

High molecular weight hydrophilic substances from dextran are obtained by reacting a hydroxyl group containing dextran substance with a bifunctional aliphatic compound containing from 1 to 10 carbon atoms, the chain of carbon atoms of which may be interrupted by ether groups and containing halogen and/or epoxy groups at the ends of the chain, which react with the hydroxyl groups of the dextran with formation of linkages of ether type, so that a polymerization product containing at least 2 of the molecules of the dextran substance bound together by ether bridges is obtained. The "dextran substances" include native or partially depolymerized dextran, ethyl, hydroxyethyl or 2-hydroxypropyl ethers of dextran, dextran glycerine glycoside, hydrodextran, or dextrans containing carboxyl, sulphonic or amino groups. Suitable bifunctional compounds are epichlorohydrin, dichlorohydrin, epibromohydrin, dibromohydrin, 1, 2, 3, 4-diepoxybutane, diepoxypropyl ether, diepoxypropyl ethers of ethylene glycol, propylene glycol and polyethylene glycols. The reaction may be effected in the presence of water or an organic solvent such as dimethylformamide, and an alkaline reacting substance such as alkali metal or alkaline earth metal hydroxides, or tertiary and quaternary amines. The temperature may vary widely but is preferably between room temperature and a temperature of 60-90 DEG C. The products obtained may be water-soluble and may be purified by precipitation with alcohols or ketones, extraction with water containing non-solvents, using ion exchangers or by dialysis. The products may also be gels which are insoluble but capable of absorbing solvent with swelling and may be purified by washing with water or solvents. The products may be subjected to partial depolymerization for correcting the average molecular weight, such as by mild hydrolysis with an acid, or alcoholysis. The products may be used for theropeutic and pharmaceutical purposes.ALSO:Hydrophilic polymerization products containing at least 2 molecules of dextran substance (i.e. native dextran, partially depolymerized dextran or derivatives thereof such as ethers glycosides or hydrodextran) bound together with ether bridges via an aliphatic radical containing 1 to 10 carbon atoms are used as plasma substitute and as disintegrating agents for tablets. In an example, a colloidal infusion for intravenous injection comprises 6% of a fraction obtained from the reaction product of dextran and epichlorohydrin, and 0,9% sodium chloride. For preparation of the polymers see Group IV(a).
GB188359A 1958-03-13 1959-01-19 Process for the manufacture of hydrophilic high molecular weight substances from dextran substances Expired GB854715A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE245258A SE169293C1 (en) 1958-03-13 1958-03-13

Publications (1)

Publication Number Publication Date
GB854715A true GB854715A (en) 1960-11-23

Family

ID=20259979

Family Applications (1)

Application Number Title Priority Date Filing Date
GB188359A Expired GB854715A (en) 1958-03-13 1959-01-19 Process for the manufacture of hydrophilic high molecular weight substances from dextran substances

Country Status (5)

Country Link
BE (1) BE576522A (en)
CH (1) CH413811A (en)
DE (1) DE1418013A1 (en)
GB (1) GB854715A (en)
SE (1) SE169293C1 (en)

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3208994A (en) * 1961-10-25 1965-09-28 Pharmacia Ab Process for preparing hydrophilic copolymerization and product obtained thereby
DE2403269A1 (en) * 1973-01-29 1974-08-08 Pharmacia Ab Means for cleaning of fluessigkeit donating hautoberflaechen, wounds and mucous membranes
DE3033885A1 (en) * 1979-09-12 1981-04-02 Pharmacia Fine Chemicals Ab A method for culturing cells
US4470975A (en) * 1977-10-21 1984-09-11 The Johns Hopkins University Method and composition for the elimination of water from an animal body
US4537767A (en) * 1973-01-29 1985-08-27 Pharmacia Aktiebolag Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method
JPH0669490B2 (en) * 1984-07-23 1994-09-07 カビ・フアーマシア・アー・ベー For preventing adhesion between body tissues, implants and a method for manufacturing the same
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
WO2001017571A1 (en) * 1999-09-03 2001-03-15 Sulzer Vascutek Limited Sealant for vascular prostheses
US7708152B2 (en) 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
US7780860B2 (en) 2002-05-24 2010-08-24 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7806276B2 (en) 2007-04-12 2010-10-05 Hanuman, Llc Buoy suspension fractionation system
US7824559B2 (en) 2005-02-07 2010-11-02 Hanumann, LLC Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7837884B2 (en) 2002-05-03 2010-11-23 Hanuman, Llc Methods and apparatus for isolating platelets from blood
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
WO2013019891A1 (en) 2011-08-01 2013-02-07 St. Hill Pharmaceutical Corporation Non-digestible capsules for the delivery of fluid absorbing materials
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US9556243B2 (en) 2013-03-15 2017-01-31 Biomet Biologies, LLC Methods for making cytokine compositions from tissues using non-centrifugal methods
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9701728B2 (en) 2008-02-27 2017-07-11 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9897589B2 (en) 2002-05-24 2018-02-20 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE452469B (en) * 1986-06-18 1987-11-30 Pharmacia Ab Material consisting of a carboxyl group-containing polysaccharide tverbunden and procedure in front tell accession thereof

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3208994A (en) * 1961-10-25 1965-09-28 Pharmacia Ab Process for preparing hydrophilic copolymerization and product obtained thereby
US4537767A (en) * 1973-01-29 1985-08-27 Pharmacia Aktiebolag Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method
DE2403269A1 (en) * 1973-01-29 1974-08-08 Pharmacia Ab Means for cleaning of fluessigkeit donating hautoberflaechen, wounds and mucous membranes
US4470975A (en) * 1977-10-21 1984-09-11 The Johns Hopkins University Method and composition for the elimination of water from an animal body
DE3033885A1 (en) * 1979-09-12 1981-04-02 Pharmacia Fine Chemicals Ab A method for culturing cells
JPH0669490B2 (en) * 1984-07-23 1994-09-07 カビ・フアーマシア・アー・ベー For preventing adhesion between body tissues, implants and a method for manufacturing the same
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US6214338B1 (en) 1994-12-07 2001-04-10 Plasmaseal Llc Plasma concentrate and method of processing blood for same
WO2001017571A1 (en) * 1999-09-03 2001-03-15 Sulzer Vascutek Limited Sealant for vascular prostheses
US7837884B2 (en) 2002-05-03 2010-11-23 Hanuman, Llc Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US8187477B2 (en) 2002-05-03 2012-05-29 Hanuman, Llc Methods and apparatus for isolating platelets from blood
US8950586B2 (en) 2002-05-03 2015-02-10 Hanuman Llc Methods and apparatus for isolating platelets from blood
US8603346B2 (en) 2002-05-24 2013-12-10 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US10183042B2 (en) 2002-05-24 2019-01-22 Biomet Manufacturing, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8163184B2 (en) 2002-05-24 2012-04-24 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7914689B2 (en) 2002-05-24 2011-03-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9114334B2 (en) 2002-05-24 2015-08-25 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7780860B2 (en) 2002-05-24 2010-08-24 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9897589B2 (en) 2002-05-24 2018-02-20 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8048321B2 (en) 2002-05-24 2011-11-01 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8062534B2 (en) 2002-05-24 2011-11-22 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8808551B2 (en) 2002-05-24 2014-08-19 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7987995B2 (en) 2005-02-07 2011-08-02 Hanuman, Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
US8133389B2 (en) 2005-02-07 2012-03-13 Hanuman, Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7824559B2 (en) 2005-02-07 2010-11-02 Hanumann, LLC Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7708152B2 (en) 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
US8105495B2 (en) 2005-02-07 2012-01-31 Hanuman, Llc Method for preparing platelet rich plasma and concentrates thereof
US8096422B2 (en) 2005-02-07 2012-01-17 Hanuman Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US7806276B2 (en) 2007-04-12 2010-10-05 Hanuman, Llc Buoy suspension fractionation system
US9138664B2 (en) 2007-04-12 2015-09-22 Biomet Biologics, Llc Buoy fractionation system
US8596470B2 (en) 2007-04-12 2013-12-03 Hanuman, Llc Buoy fractionation system
US8119013B2 (en) 2007-04-12 2012-02-21 Hanuman, Llc Method of separating a selected component from a multiple component material
US9649579B2 (en) 2007-04-12 2017-05-16 Hanuman Llc Buoy suspension fractionation system
US9701728B2 (en) 2008-02-27 2017-07-11 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US8801586B2 (en) 2008-02-29 2014-08-12 Biomet Biologics, Llc System and process for separating a material
US9719063B2 (en) 2008-02-29 2017-08-01 Biomet Biologics, Llc System and process for separating a material
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8783470B2 (en) 2009-03-06 2014-07-22 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8992862B2 (en) 2009-04-03 2015-03-31 Biomet Biologics, Llc All-in-one means of separating blood components
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9533090B2 (en) 2010-04-12 2017-01-03 Biomet Biologics, Llc Method and apparatus for separating a material
US9239276B2 (en) 2011-04-19 2016-01-19 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2013019891A1 (en) 2011-08-01 2013-02-07 St. Hill Pharmaceutical Corporation Non-digestible capsules for the delivery of fluid absorbing materials
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9556243B2 (en) 2013-03-15 2017-01-31 Biomet Biologies, LLC Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force

Also Published As

Publication number Publication date
BE576522A (en) 1959-09-10
DE1418013A1 (en) 1968-10-17
SE169293C1 (en) 1959-11-10
CH413811A (en) 1966-05-31
BE576522A1 (en)

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