GB2371992A - Tracheal tubes - Google Patents
Tracheal tubes Download PDFInfo
- Publication number
- GB2371992A GB2371992A GB0128824A GB0128824A GB2371992A GB 2371992 A GB2371992 A GB 2371992A GB 0128824 A GB0128824 A GB 0128824A GB 0128824 A GB0128824 A GB 0128824A GB 2371992 A GB2371992 A GB 2371992A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tube
- suction
- opening
- tracheal
- tracheal tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0465—Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0475—Tracheal tubes having openings in the tube
- A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
- A61M16/0479—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids above the cuff, e.g. giving access to the upper trachea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0486—Multi-lumen tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/0497—Tube stabilizer
Abstract
A tracheostomy tube has a sealing cuff 2 inflated by an inflation tube 20 extending in a channel 21 along one side of the tracheostomy tube. A suction tube 26 extends in a channel 27 along the opposite side of the tracheostomy tube. The suction tube 26 extends to the upper end of the sealing cuff 2 and opens into a recess 29 on the outside of the tracheostomy tube though a side opening 32 oriented at right angles to the radius of the tracheostomy tube. The recess 29 extends around about 90{ of the tube towards its outer curve so that secretions that collect in this region can be removed.
Description
l TRACHEAL TUBES
This invention relates to tracheal tubes.
Cuffed tracheal tubes, in particular, tracheostomy tubes, can present a problem in that secretions produced in the trachea may collect outside the tube above the cuff, providing a site for the accumulation of bacteria and infection.
Various proposals have been made previously for removing such secretions by suctioning from above the cuff. US 4607635 describes a tracheal tube having a channel open at various locations along its length and through which a suction catheter can be inserted to remove secretions at any desired location above the cuff. In US 4305392 there is described a tracheal tube with a bulbous chamber above the cuff in which secretions are collected for removal through a suction lumen extending through the wall ofthe tube. US 4840173 describes a catheter having a suction tube projecting over the proximal collar of the cuff to increase the amount of secretions that can be collected. GB 2250440 describes a tube where the upper end of the cuff is everted within the cuff so that it does not provide any obstruction to locating a suction opening as close as possible to the cuff.
One difficulty with previous tubes is in ensuring that the maximum amount of secretions are removed. A further problem with some previous tubes is that when suction is applied, this can suck adjacent tissue onto the suction opening, thereby closing it or valving off the suction path.
It is an object of the present invention to provide an alternative tracheal tube.
According to the present invention there is provided a tracheal tube having a sealing cuff towards one end and a suction lumen extending longitudinally along a part of the length of the tube and having an opening just above the upper end of the cuff on the outside of the tube, the opening of the suction lumen opening into a recess on the outside of the tube, and the recess extending laterally away from the opening such that secretions collecting at a location laterally displaced from the opening can be removed via the recess and the suction lumen. The tracheal tube is preferably curved along a part at least of its length, the suction lumen extending along one side of the tube and the recess extending from the opening to a location closer to the outside curve of the tube. The recess preferably extends through substantially 90 around the circumference of the tracheal tube. The suction tube may be provided by a separate tube attached to the outside of the tracheal tube, preferably the suction tube extends along a channel formed in the outside of the tracheal tube. The suction tube may open into the recess through a side opening in the suction tube and preferably the side opening is oriented at substantially right angles to the radius of the tracheal tube. The tracheal tube preferably includes an inflation lumen opening into the cuff and the inflation lumen may extend along the tracheal tube diametrically opposite the suction lumen.
A tracheostomy tube according to the present invention will now be described, by way of example, with reference to the accompanying drawings, in which:
Figure 1 is a perspective view of the tube; Figure 2 is an enlarged perspective view of a part of the tube, with the cuff omitted, for clarity; Figure 3 is a side elevation view of the tube from one side; Figure 4 is a side elevation view of the tube from the opposite side; Figure 5 is a front elevation view of the tube; and Figure 6 is a perspective view of a part of a modified tube.
With reference first to Figures 1 to 5, the tube includes a tubular shaft 1 curved along its length and having an inflatable sealing cuff2 towards its patient end 3. The tube also has a flange 4 and coupling 5 at its rear or machine end 6. The shaft 1, flange 4 and coupling 5 are integrally moulded with one another as a single piece from a plastics material, such as PVC.
The cuff 2 is inflated by means of an inflation lumen provided by a smallbore tube 20 extending along one side of the shaft 1 in a semicylindrical channel 21 moulded into its outside surface. The machine end of the channel 21 leads to an outwardly-inclined ramp 22 on the shaft 1, which supports the inflation tube 20 where it extends through a hole 23 in the flange 4. The machine end of the inflation tube 20 is terminated by a conventional connector and inflation indicator (not shown),
On its opposite side, the tube has a suction tube 26 extending parallel to the inflation tube 20. The suction tube 26 has a larger diameter than the inflation tube 20 and extends in a similar semi-cylindrical channel 27 moulded longitudinally along the outside surface of the shaft 1. The forward or patient end 28 of the channel 27 opens into a recess or gutter 29 in the outer surface of the shaft 1. The gutter 29 extends laterally at right-angles to the channel 27 through about 90 around the circumference of the shaft 1, so that its far end 30 is located on the outside of the curve of the shaft. The patient end 31 of the suction tube 26 is closed, the tube opening just rearwardly of its patient end through an elongate side opening 32. The side opening 32 is oriented at right angles to the radius of the shaft 1 to face into the gutter 29.
This arrangement presents less risk of occlusion because the opening 32 does not face outwardly towards the patient tissue; the relatively large area of the gutter 29 means that it is less likely to be completely obstructed by contact with adjacent tissue.
The machine end of the channel 27 leads to an outwardly-inclined ramp 33 on the shaft 1, which supports the suction tube 26 where it extends through a hole 34 in the flange 4 diametrically opposite the inflation tube hole 23.
The gutter 29 enables suctioning of the region on the outside of the curve of the tube, which lies posteriorly of the trachea in use, where most secretions collect when the patient is in the usual supine position. This helps ensure that the maximum amount of secretions are removed when suction is applied to the machine end of the suction tube 26. The suction tube 26 still, however, extends along the side of the tube, which is the preferred location
anatomically because it minimizes the risk of trauma to tracheal cartilages. This enables the diameter of the suction tube to be a maximum, so as to reduce the risk of blockages.
The suction tube need not open through a side opening. The tracheal tube could have a suction tube 40 that opens at its end 41 in the manner shown in Figure 6. In this arrangement, the suction tube 40 terminates at the upper end of the gutter 42 and the tracheal tube is moulded with an integral, outwardly-projecting elongate limb 43 located at the patient side of the gutter in line with the channel 44. The limb 43 is bent down and its free end 45 is bonded to the outside of the suction tube 40 close to its end. In this way, the limb 43 forms a longitudinally-extending bridge with the suction tube 40 and is spaced above the surface of the shaft of the tracheal tube so that the suction tube opens on opposite sides of the limb through apertures 46 and 47. The limb 43 forms an antiocclusion formation for the suction tube 40 and, because it extends longitudinally and covers the end 41 of the tube, it smoothes contact with tissue during insertion, thereby further reducing trauma.
It will be appreciated that the invention is not confined to tracheostomy tubes but could be used in other tracheal tubes.
Claims (11)
1. A tracheal tube having a sealing cuff towards one end and a suction lumen extending longitudinally along a part of the length of the tube and having an opening just above the upper end of the cuff on the outside of the tube, wherein the opening of the suction lumen opens into a recess on the outside of the tube, and wherein the recess extends laterally away from the opening such that secretions collecting at a location laterally displaced from the opening can be removed via the recess and the suction lumen.
2. A tracheal tube according to Claim 1, wherein the tube is curved along a part at least
of its length, wherein the suction lumen extends along one side of the tube, and wherein the recess extends from the opening to a location closer to the outside curve of the tube.
3. A tracheal tube according to Claim 1 or 2, wherein the recess extends through substantially 90 around the circumference of the trachea tube.
4. A tracheal tube according to any one of the preceding claims, wherein the suction lumen is provided by a separate tube attached to the outside of the tracheal tube.
5. A tracheal tube according to Claim 4, wherein the suction tube extends along a channel formed in the outside of the tracheal tube.
6. A tracheal tube according to Claim 4 or 5, wherein the suction tube opens into the recess through a side opening in the suction tube.
7. A tracheal tube according to Claim 6, wherein the side opening is oriented at substantially right angles to the radius of the tracheal tube.
8. A tracheal tube according to any one of the preceding claims including an inflation lumen opening into the cuff, wherein the inflation lumen extends along the tracheal tube diametrically opposite the suction lumen.
9. A tracheal tube substantially as hereinbefore described with reference to Figures 1 to 5 of the accompanying drawings.
10. A tracheal tube substantially as hereinbefore described with reference to Figures 1 to 5 as modified by Figure 6 of the accompanying drawings.
11. Any novel and inventive feature or combination of features as hereinbefore described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0031598A GB0031598D0 (en) | 2000-12-23 | 2000-12-23 | Tracheal tubes |
GB0105037A GB0105037D0 (en) | 2001-03-01 | 2001-03-01 | Trachael tubes |
Publications (3)
Publication Number | Publication Date |
---|---|
GB0128824D0 GB0128824D0 (en) | 2002-01-23 |
GB2371992A true GB2371992A (en) | 2002-08-14 |
GB2371992B GB2371992B (en) | 2004-08-18 |
Family
ID=26245494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0128824A Expired - Lifetime GB2371992B (en) | 2000-12-23 | 2001-11-30 | Tracheal tubes |
Country Status (9)
Country | Link |
---|---|
US (1) | US6796309B2 (en) |
EP (1) | EP1219317B1 (en) |
JP (1) | JP2002210014A (en) |
AT (1) | ATE328631T1 (en) |
AU (1) | AU779249B2 (en) |
CA (1) | CA2365638C (en) |
DE (1) | DE60120335T2 (en) |
ES (1) | ES2261354T3 (en) |
GB (1) | GB2371992B (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6662804B2 (en) * | 2001-11-02 | 2003-12-16 | Antonio Ortiz | Tracheostomy tube with cuff on inner cannula |
US20040255951A1 (en) * | 2003-02-07 | 2004-12-23 | Christopher Grey | Endotrachael tube with suction catheter and system |
US7195016B2 (en) * | 2004-01-07 | 2007-03-27 | E. Benson Hood Laboratories | Transtracheal oxygen stent |
EP1744805A4 (en) * | 2004-05-12 | 2008-08-13 | Nellcor Puritan Bennett Inc | Endotracheal tube having improved suction lumen |
JP4539974B2 (en) * | 2004-10-05 | 2010-09-08 | 日本シャーウッド株式会社 | Tracheostomy tube |
US7478636B2 (en) * | 2005-08-08 | 2009-01-20 | Kimberly-Clark Worldwide, Inc. | Multilumen tracheal catheter to prevent cross contamination |
US7581541B2 (en) * | 2005-08-08 | 2009-09-01 | Kimberly-Clark Worldwide, Inc. | Multilumen tracheal catheter |
CN101296724B (en) * | 2005-08-24 | 2013-01-09 | 呼吸医疗技术有限公司 | Adjustment of endotracheal tube cuff filling |
US20070044807A1 (en) * | 2005-08-25 | 2007-03-01 | Kimberly-Clark Worldwide, Inc. | Multilumen tracheal catheter with rinse lumen |
US7293561B2 (en) * | 2005-08-25 | 2007-11-13 | Kimberly-Clark Worldwide, Inc. | Low profile adapter for tracheal tubes |
US7600515B2 (en) * | 2005-09-28 | 2009-10-13 | Nellcor Puritan Bennett Llc | Tracheostomy tube combination radial snap and bayonet cannula connector |
US7647929B2 (en) * | 2005-09-28 | 2010-01-19 | Nellcor Puritan Bennett Llc | Medical device tube having a flange with opposing support ears for improved alignment and retention of an inner cannula in an outer cannula |
US20070089748A1 (en) * | 2005-10-26 | 2007-04-26 | Madsen Edward B | Tracheal catheter with closeable suction lumen |
US20070113855A1 (en) * | 2005-11-18 | 2007-05-24 | Kimberly-Clark Worldwide, Inc. | Respiratory apparatus with improved seal |
JP5507847B2 (en) * | 2005-12-05 | 2014-05-28 | ホスピテック レスピレーション リミテッド | Endotracheal tube and intubation system including the same |
US8434487B2 (en) | 2006-06-22 | 2013-05-07 | Covidien Lp | Endotracheal cuff and technique for using the same |
US8196584B2 (en) | 2006-06-22 | 2012-06-12 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
US7654264B2 (en) | 2006-07-18 | 2010-02-02 | Nellcor Puritan Bennett Llc | Medical tube including an inflatable cuff having a notched collar |
US8936025B2 (en) | 2006-09-26 | 2015-01-20 | Covidien Lp | Tracheostomy tube and technique for using the same |
US8307830B2 (en) | 2006-09-29 | 2012-11-13 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
US7950393B2 (en) | 2006-09-29 | 2011-05-31 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
US7913693B2 (en) * | 2006-11-10 | 2011-03-29 | Nellcor Puritan Bennett Llc | Method and apparatus for preventing occlusion of a tracheal tube suction lumen |
US20090071484A1 (en) * | 2007-09-14 | 2009-03-19 | Paul William Black | Endotracheal tube with intrinsic suction & endotracheal suction control valve |
US8607795B2 (en) | 2007-09-20 | 2013-12-17 | Kimberly-Clark Worldwide, Inc. | Balloon cuff tracheostomy tube |
US8313687B2 (en) | 2007-09-20 | 2012-11-20 | Kimberly-Clark Worldwide, Inc. | Method of making an improved balloon cuff tracheostomy tube |
US8750978B2 (en) | 2007-12-31 | 2014-06-10 | Covidien Lp | System and sensor for early detection of shock or perfusion failure and technique for using the same |
JP2010000140A (en) * | 2008-06-18 | 2010-01-07 | Tokunaga Soki Kenkyusho:Kk | Suction endotracheal tube |
US20090320853A1 (en) * | 2008-06-27 | 2009-12-31 | Mike Kenowski | Tracheostomy Tube |
EP2349423B1 (en) * | 2008-10-24 | 2014-02-26 | Hospitech Respiration Ltd. | Ventilation system |
DE102009013424B4 (en) * | 2009-03-18 | 2014-02-13 | Andreas Fahl Medizintechnik-Vertrieb Gmbh | Sucked tracheostomy tube, secretion evacuation method, and method of making a cannula tube |
US8590534B2 (en) | 2009-06-22 | 2013-11-26 | Covidien Lp | Cuff for use with medical tubing and method and apparatus for making the same |
US20110041854A1 (en) * | 2009-08-18 | 2011-02-24 | Julia Suzanne Rasor | Everting device and method for tracheostomy |
US8439041B2 (en) | 2010-03-31 | 2013-05-14 | Covidien Lp | Tracheal tube with scaffolding-supported wall |
US8602030B2 (en) * | 2010-06-30 | 2013-12-10 | Covidien Lp | Tracheal tubes with improved secretion removal systems |
US20130112207A1 (en) * | 2011-11-09 | 2013-05-09 | Teleflex Medical Incorporated | Endotracheal tube with dual port subglottic secretion suctioning |
DE102011120694A1 (en) * | 2011-12-05 | 2013-06-06 | Primed Halberstadt Medizintechnik Gmbh | Outer cannula of a tracheostoma prosthesis for easy insertion and removal of an inner cannula |
US9352112B2 (en) | 2011-12-13 | 2016-05-31 | Covidien Lp | Shaped evacuation port for a multi-lumen tracheal tube |
US9010326B2 (en) | 2012-08-02 | 2015-04-21 | Covidien Lp | Compressible connector for an inner cannula |
TW201410280A (en) * | 2012-09-12 | 2014-03-16 | Ying-Jie Su | Tracheostomy tube assembly with phlegm-suction function |
AU2013201131B2 (en) * | 2012-12-03 | 2015-02-19 | Hansa Medical Products, Inc. | Endotracheal tube having outer and inner cannulae |
US9265906B2 (en) | 2013-02-25 | 2016-02-23 | Covidien Lp | Compressible cannula connector with release grip |
US10952593B2 (en) * | 2014-06-10 | 2021-03-23 | Covidien Lp | Bronchoscope adapter |
JP6751355B2 (en) * | 2015-02-10 | 2020-09-02 | テルモ株式会社 | Flange member |
WO2019183338A1 (en) | 2018-03-21 | 2019-09-26 | Hansa Medical Products, Inc. | Medical device system and method including an endotracheal tube |
GB201810952D0 (en) | 2018-07-04 | 2018-08-15 | Smiths Medical International Ltd | Tracheal tubes, assemblies and methods |
USD858747S1 (en) * | 2018-07-05 | 2019-09-03 | Primed Halberstadt Medizintechnik Gmbh | Tracheal tube |
USD858748S1 (en) * | 2019-03-04 | 2019-09-03 | Primed Halberstadt Medizintechnik Gmbh | Neck plate for tracheal tube |
CN110448390B (en) * | 2019-09-04 | 2021-06-01 | 查君敬 | Oral cavity lavage auxiliary device for trachea cannula patient |
DE102020135139A1 (en) | 2020-12-30 | 2022-06-30 | Tracoe Medical Gmbh | Ventilation device with speaking air supply |
DE102020135146A1 (en) | 2020-12-30 | 2022-06-30 | Tracoe Medical Gmbh | Respirator with ostomy cuff |
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US4762125A (en) * | 1986-03-07 | 1988-08-09 | The University Of Texas System | Balloon-tipped suction catheter |
JPH105340A (en) * | 1996-06-19 | 1998-01-13 | Nippon Sherwood Kk | Trachea incision tube with suction lumens of upper part of cuff |
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-
2001
- 2001-11-29 DE DE60120335T patent/DE60120335T2/en not_active Expired - Lifetime
- 2001-11-29 AT AT01309987T patent/ATE328631T1/en not_active IP Right Cessation
- 2001-11-29 EP EP01309987A patent/EP1219317B1/en not_active Expired - Lifetime
- 2001-11-29 ES ES01309987T patent/ES2261354T3/en not_active Expired - Lifetime
- 2001-11-30 GB GB0128824A patent/GB2371992B/en not_active Expired - Lifetime
- 2001-12-07 US US10/005,227 patent/US6796309B2/en not_active Expired - Lifetime
- 2001-12-11 AU AU97188/01A patent/AU779249B2/en not_active Ceased
- 2001-12-20 CA CA002365638A patent/CA2365638C/en not_active Expired - Fee Related
- 2001-12-25 JP JP2001391312A patent/JP2002210014A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4762125A (en) * | 1986-03-07 | 1988-08-09 | The University Of Texas System | Balloon-tipped suction catheter |
JPH105340A (en) * | 1996-06-19 | 1998-01-13 | Nippon Sherwood Kk | Trachea incision tube with suction lumens of upper part of cuff |
Non-Patent Citations (1)
Title |
---|
WPI Abstract Accession No 1998-124103 & JP 10005340 A (NIPPON SHERWOOD KK) * |
Also Published As
Publication number | Publication date |
---|---|
CA2365638C (en) | 2009-07-07 |
AU779249B2 (en) | 2005-01-13 |
US6796309B2 (en) | 2004-09-28 |
US20020078962A1 (en) | 2002-06-27 |
DE60120335D1 (en) | 2006-07-20 |
GB0128824D0 (en) | 2002-01-23 |
JP2002210014A (en) | 2002-07-30 |
DE60120335T2 (en) | 2006-10-05 |
EP1219317A3 (en) | 2004-01-14 |
ATE328631T1 (en) | 2006-06-15 |
EP1219317A2 (en) | 2002-07-03 |
GB2371992B (en) | 2004-08-18 |
CA2365638A1 (en) | 2002-06-23 |
ES2261354T3 (en) | 2006-11-16 |
AU9718801A (en) | 2002-06-27 |
EP1219317B1 (en) | 2006-06-07 |
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