GB2292887A - Drug delivery system - Google Patents
Drug delivery systemInfo
- Publication number
- GB2292887A GB2292887A GB9523475A GB9523475A GB2292887A GB 2292887 A GB2292887 A GB 2292887A GB 9523475 A GB9523475 A GB 9523475A GB 9523475 A GB9523475 A GB 9523475A GB 2292887 A GB2292887 A GB 2292887A
- Authority
- GB
- United Kingdom
- Prior art keywords
- delivery system
- drug delivery
- lectin
- active agent
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Abstract
A drug delivery system is provided which comprises a lectin and a pharmacologically active agent in which the active agent is releasably bound to the lectin. The lectin has been found to selectively attach to glycoproteins e.g. within the cornea of the eye, thereby enabling a drug to be selectively delivered thereto.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9523475A GB2292887B (en) | 1993-04-16 | 1994-04-15 | Drug delivery system |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939307904A GB9307904D0 (en) | 1993-04-16 | 1993-04-16 | Drug delivery system |
GB939324682A GB9324682D0 (en) | 1993-12-01 | 1993-12-01 | Drug delivery system |
PCT/GB1994/000806 WO1994023752A1 (en) | 1993-04-16 | 1994-04-15 | Drug delivery system |
GB9523475A GB2292887B (en) | 1993-04-16 | 1994-04-15 | Drug delivery system |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9523475D0 GB9523475D0 (en) | 1996-01-17 |
GB2292887A true GB2292887A (en) | 1996-03-13 |
GB2292887B GB2292887B (en) | 1997-05-07 |
Family
ID=26302771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9523475A Expired - Fee Related GB2292887B (en) | 1993-04-16 | 1994-04-15 | Drug delivery system |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6510094A (en) |
GB (1) | GB2292887B (en) |
WO (1) | WO1994023752A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020001600A1 (en) * | 1995-05-30 | 2002-01-03 | Michael J. Oldham | Method of using lectins for prevention and treatment of skin diseases and disorders |
WO1997005267A2 (en) * | 1995-07-26 | 1997-02-13 | Maxim Pharmaceuticals | Mucosal delivery of polynucleotides |
GB0213383D0 (en) * | 2002-06-11 | 2002-07-24 | Cambridge Biotechnology Ltd | Therapeutic conditions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993000076A1 (en) * | 1991-06-24 | 1993-01-07 | Minnesota Mining And Manufacturing Company | Carrier systems for drugs |
-
1994
- 1994-04-15 AU AU65100/94A patent/AU6510094A/en not_active Abandoned
- 1994-04-15 WO PCT/GB1994/000806 patent/WO1994023752A1/en active Application Filing
- 1994-04-15 GB GB9523475A patent/GB2292887B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993000076A1 (en) * | 1991-06-24 | 1993-01-07 | Minnesota Mining And Manufacturing Company | Carrier systems for drugs |
Also Published As
Publication number | Publication date |
---|---|
GB2292887B (en) | 1997-05-07 |
AU6510094A (en) | 1994-11-08 |
GB9523475D0 (en) | 1996-01-17 |
WO1994023752A1 (en) | 1994-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20080415 |