GB2259014A - Compositions containing flavonoids - Google Patents

Compositions containing flavonoids Download PDF

Info

Publication number
GB2259014A
GB2259014A GB9217821A GB9217821A GB2259014A GB 2259014 A GB2259014 A GB 2259014A GB 9217821 A GB9217821 A GB 9217821A GB 9217821 A GB9217821 A GB 9217821A GB 2259014 A GB2259014 A GB 2259014A
Authority
GB
United Kingdom
Prior art keywords
composition according
weight
derivative
flavonoid
ascorbic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9217821A
Other versions
GB9217821D0 (en
GB2259014B (en
Inventor
Nira Hadas
Meir Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fischer Pharmaceuticals Ltd
Original Assignee
Fischer Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fischer Pharmaceuticals Ltd filed Critical Fischer Pharmaceuticals Ltd
Publication of GB9217821D0 publication Critical patent/GB9217821D0/en
Publication of GB2259014A publication Critical patent/GB2259014A/en
Application granted granted Critical
Publication of GB2259014B publication Critical patent/GB2259014B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

Cosmetic compositions for brightening the skin and removing or brightening dark skin spots comprise a flavonoid and ascorbic acid or its derivatives. Optional components are kojic acid, tocophcryl and sun filters. Product may be a lotion, gel, cream or spray. Flavonoids may be in form of plant extracts.

Description

Several causes, including genetic control and environmental factors such as ultra violet irradiation and hormones, regulate melanogenesis. Abnormal response of melanocytes to the above causes may result in increase in accumulation of melanin in the skin in the form of brown spots.
SUMMARY OF THE INVENTION The present invention relates to novel cosmetic compositions, for topical application to a user's skin, which result in whitening of the skin and which prevent to a large extent formation of brown spots.
The compositions of the invention comprise in combination flavonoids, which are effective in eliminating or at least greatly reducing the quantity of pigments which have formed in the skin as a result of UV irradiation, and ascorbic acid or a suitable derivative thereof. Ascorbic acid (or its physiologically acceptable derivatives) result in reduction of DOPA-quinone to DOPA, and also convert colored oxidized melanin to a colorless reduced form thereof. Advantageously there are used flavonoids derived from plant extracts, or plant extracts as such which contain an adequate concentration of such flavonoids. Synthetic flavonoids can also be used. Compositions of the present invention also are suitable for reduction of melanin formation in early stages of such formation and for prevention of formation of new spots.Novel fade compositions of this invention exert a pronounced whitening and brightening effect on brown skin spots.
Preferred plant extracts for use according to the invention are those obtained from Achillea millefolium, Calendula, Sage, Witch hazel and Mulberries.
Preparations of the invention advantageously contain a suitable carrier or vehicle, and also one or more additional component selected from tocopherol derivatives, Kojic acid; UVA, UVB and visible light chemical and physical sun filters; minerals such as titanium dioxide. Suitable sun filters are of the commercial readily available form, such as octyl methoxycinnamate, butyl methoxydibenzoylmethane, etc. A wide variety of formultations can be used, and the following illustrations exemplify some possible types of their formulations.
Generally formulations of the invention contain as ingredients from about 0.1 weight-% of an extract of one or more of the following: Achillea millefolium, Calendula, Sage, Witch hazel, Mulberries. Other plant extracts containing appreciable quantities of flavonoids can be used. The formulations generally contain from about 0.1 weight-% to about 30 weight-% of such plant extracts, or a corresponding quantity of purified flavonoids. The second ingredient is a physiologically acceptable derivative of aseorbic acid, such as ascorbyl palmitate, ascorbyl stearate, magnesium ascorbyl phosphate and the like. The second ingredient comprises about 0.1 weight-% to about 5 weight-% of the composition.
Licorice extract, 0.01 weight-% to about 5 weight-% is a preferred component.
The formulations advantageously also contain as an ingredient a suitable sun filter, such as for example UVA, UVB and visible light; octyl methoxycinnamate, butyl methoxydibenzoyl methane. A further substance of similar effect is Tiro2. Generally these ingredients comprise from about 2 weight-% to about 10 weight-% of the formulation. A further optional, advantageous ingredient is a suitable tocopheryl derivative, such as tocopheryl linoleate. Compounds of this type, when used, comprise from about 0.1 weight-% to about 5 weight-% of the formulation.
Another optional advantageous ingredient, adapted to suppress tyrosinase activity, probably due to copper chelation, is Kojic acid. This ingredient is used at a concentration from about 0.1 weight-% to about 5 weight-% of the formulation.
The following examples, which are to be construed in a non-limitative manner, illustrate the preparation of a number of effective formulations of the invention in cream, lotion, spray and gel form: Example 1: Cream Extract of Achillea millefolium 20% Magnesium ascorbyl palmitate 5% Cream base ad 100 Example 2: Cream Extract of Mulberries 25% Ascorbic acid 0.1% Cream base ad 100 Example 3: Cream Extract of Achillea millefolium 15% Ascorbyl stearate 5% Tio2 10% Cream base ad 100 Example 4: Lotion Extract of Achillea millefolium 10% Ascorbyl palmitate 0.5 Octyl methoxycinnamate 7.5 Butyl methoxydibenzoylmethane 0.5 Tio2 10% Kojic acid 3% Lotion base ad 100 Example 5:Lotion Extract of Achillea millefolium 5% Ascorbyl palmitate 0.5 Benzophenone 5% TiO2 10% Tocopheryl linoleate 1% Lotion base ad Example 6: Lotion Kojic acid 2% Tio2 5% Lotion base ad Example 7: Gel Kojic Acid 0.1% WA & UVB sun filters Gel base ad 100 Example 8: Lotion Ascorbyl palmitate 0.1% Tocopheryl linoleate 3% Kojic acid 0.5% Lotion base ad 100 Example 9: Cream Ingredient Ascorbyl palmitate 4 Achillea millefolium, water soluble extract (containing 3% flavonoids) 1 Tocopheryl linoleate 0.1 Octyl methoxycinnamate 2 Butyl methoxydibenzoylmethane 0.75 TiO2 1 Kojic acid 0.1 Panthenol 1 Chamomile ext 0.1 IPM 2 BHT 0.04 Preservatives 0.5 Stearic acid 4 Na2EDTA 0.1 DEA cetyl phosphate 3.5 Cetyl alcohol 2 Glycerin stearate 4 Aq dest ad 100 Example 10:Cream Ingredient Ascorbyl palmitate 0.1 Achillea millefolium, water soluble extract (containing 3% flavonoids) 30 Tocopheryl linoleate 5 Octyl methoxycinnamate 7 Butyl methoxydibenzoylmethane 3 Tio2 10 Kojic acid 5 Panthenol 1 Chamomile ext 0.1 IPM 2 BHT 0.04 Preservatives 0.5 Stearic acid 4 Na2EDTA 0.1 DEA cetyl phosphate 3.5 Cetyl alcohol 2 Glycerin stearate 4 Aq dest ad 100 Example 11: Lotion Incrredient Ascorbyl palmitate 0.1 Achillea millefolium, water soluble extract (containing 3% flavonoids) 30 Tocopheryl linoleate 5 Octyl methoxycinnamate 7 Butyl methoxydibenzoylmethane 3 Tio2 10 Kojic acid 5 Panthenol 1 Chamomile ext 0.1 IPM 2 BHT 0.04 Preservatives 0.5 Stearic acid 2 Na2EDTA 0.1 DEA cetyl phosphate 3.5 Cetyl alcohol 0.2 Glycerin stearate 2 Aq dest ad Example 12: Lotion Ingredient Ascorbyl palmitate 4 Achillea millefolium, water soluble extract (containing 3% flavonoids) 1 Tocopheryl linoleate 0.1 Octyl methoxycinnamate 2 Butyl methoxydibenzoylmethane 0.75 Tio2 1 Kojic acid 0.1 Panthenol 1 Chamomile ext 0.1 IPM 2 BHT 0.04 Preservatives 0.5 Stearic acid 2 Na2EDTA 0.1 DEA cetyl phosphate 3.5 Glycerin stearate 2 Aq dest ad 100 Example 13: Gel Ingredient Ascorbyl palmitate 0.5 Achillea millefolium, water soluble extract (containing 3% flavonoids) 1 Polysorbate 6 Carbopol 1 Triethanolamine 4.2 Preservative 1 Kojic acid 5 TiO2 1 Tocopheryl linoleate 2 Panthenol 1 Phenylbenzimidazol-5 sulfonic acid 6 Water ad 100 Example 14:Gel Ingredient % Ascorbyl palmitate 3 Achillea millefolium, water soluble extract (containing 3% flavonoids) 25 Tocopheryl linoleate 0.5 Polysorbate 6 Carbopol 1 Triethanolamine 1.6 Preservative 1 Kojic acid 0.1 Phenylbenzimidazol-5 sulfonic acid 0.1 Tio2 1 Panthenol 1 Water ad 100 Example 15: Liquid Ingredient Ascorbyl palmitate 3 Achillea millefolium, water soluble extract (containing 3% flavonoids) 25 Tocopheryl linoleate 0.5 Polysorbate 10 Triethanolamine 0.05 Preservative 1 Kojic acid 0.1 Phenylbenzimidazol-5 sulfonic acid 0.1 TiO2 10 Panthenol 1 Water ad 100 Example 16:Liquid Ingredient Ascorbyl palmitate 0.5 Achillea millefolium, water soluble extract (containing 3% flavonoids) 1 Polysorbate 10 Preservative 1 Kojic acid 5 Tio2 1 Tocopheryl linoleate 2 Panthenol 1 Phenylbenzimidazol-5 sulfonic acid 6 Triethanolamine 3.1 Water ad 100 Example 17: Gel Ingredient Ascorbyl palmitate 3 Sohakuhl (mulberries) water soluble extract 20 Tocopheryl linoleate 0.5 Po lysorbate 6 Carbopol 1 Triethanolamine 1.6 Preservative 1 Kojic acid 0.1 Phenylbenzimidazol-5 sulfonic acid 0.1 TiO2 1 Panthenol 1 Water ad 100 Example 18:Gel Ingredient Ascorbyl palmitate 0.5 Sohakuhl (mulberries) water soluble extract 1 Polysorbate 6 Carbopol 1 Triethanolamine 4.2 Preservative 1 Kojic acid 5 TiO2 10 Tocopheryl linoleate 1 Panthenol 1 Phenylbenzimidazol-5 sulfonic acid 6 Water ad 100 EXAMPLE 19 Ingredients Cetyl alcohol 5 Glycerylstearate SE 3 Capryl/caprylate triglyceride 3 P E G 6000 distearate 1 Achillea millefolium ext 1 Licorice ext 0.05 Ascorbyl palmitate 0.5 Tocopheryl linoleate 0.2 Titanium dioxide 2 Glycolic acid 5 Preservatives 9.5 Xantan gum 0.3 NH OH ad pH-4 H 0 dest ad 100 EXAMPLE 20 Ingredients ~ Achillea millefolium ext 2 Kojic acid 0.5 Ascorbyl palmitate 0.2 -hydroxyacid (as glycolic acid) 5 Lotion base ad 100 In the following Examples the licorice extract used was licorice extract TP (Glycyrrhiza Glabra) produced by Nikko Chemicals, Japan. Percentages are by weight.
EXAMPLE 21 Ingredients % Licorice extract 0.05 Extract of Achillae millefolium 3.0 Ascorbyl palmitate 0.5 Cream base ad 100 EXAMPLE 22 Ingredients 8 Licorice extract 0.1 Ascorbyl palmitate 1.0 Tocopheryl linoleate 0.5 Lotion base ad 100 EXAMPLE 23 Ingredients ~ Licorice extract 4.0 Achillea millefolium ext 3.0 Tocopheryl linoleate 0.5 Butyl methoxydibenzoylmethane 1.5 Titanium dioxide 5.0 Chamomille ext 0.1 1PM 2.0 BHT 0.04 Preservatives 0.5 Stearic acid 2.0 Na EDTA 0.1 DEA cetyl phosphate 3.5 Cetyl alcohol 0.2 Glycerin stearate 2.0 Aq. dest ad 100 It will be understood by those familiar with formulation of cosmetic products that wide deviations may be made from the foregoing preferred formulations, without departing from a main theme of invention set forth in claims which follow.
Extensive experiments were carried out which led to the compositions of the present invention.
Criteria used in the evaluations were arbitrary scales of value of 0,1,2 and 3 regarding number of spots, regarding color of spots, level of contrast. Skin types were categorized in four categories according to severity of sunburn and ease of tanning. Experiments were carried out with human female and male subjects who agreed with the tests. They were between the ages of 50 and 92 years, and only such subjects were tested who had bilateral symmetrical age spots on the dorsum surface of both hands, who had an adequate number of such spots which were of a dark enough color and contrast.
Tests were carried out with the main components, each by itself, and after this various combinations were tested, and different dosages (concentrations) were employed.
Ascorbic acid and its derivatives exerted a certain effect, but at relatively high doses. Also the various flavonoids mentioned were tested by themselves, and had a certain effect.
It was found surprisingly that the combination of these two components increased the effect in a pronounced manner, even when smaller doses were used than before. The addition to these of either tocopheryl derivatives or of kojic acid further enhanced the whitening effect, and this iso in a manner which can be explained by a synergistic effect.
It is likely that the various components, and especially ascorbic acid and its derivatives, as well as the flavonoids exert their effect via various pathways.
This applies also to kojic acid which apparently inactivates an enzyme enhancing melanin formation.
The whitening effect of the compositions of the present invention is a very pronounced one and requires application of a formulation of the invetion during about 2 to 3 months.
As stated above, it is very likely that ascorbic acid, its derivatives together with the flavonoids defined, exert a synergistic effect, which is further enchanced by components such as tocopherol or kojic acid.

Claims (12)

CLAIMS:
1. A composition for the brightening of skin and skin spots by topical application, in solution, lotion, gel, spray or cream form, comprising in combination an effective quantity of a flavonoid and an effective quantity of ascorbic acid or a suitable derivative thereof, if desired in combination with a sun filter, an agent adapted to suppress tyrosinase activity or a tocopheryl derivative.
2. A composition according to Claim 1, where the flavonoid is in the form of a plant extract or in purified form derived from Achillea Millefolium, Candula, Sage, Witch Hazel and Mulberries.
3. A composition according to Claim 1 or 2, where the sun filter is one or more UVA, UVB, IR and/or visible light such as octyl methoxycinnamate, butyl methoxydibenzoyl methane and titanium dioxide.
4. A composition according to any of Claims 1 to 3, where the DOPA-quinone reducing agent is ascorbic acid, ascorbyl palmitate, ascorbyl stearate, magnesium ascorbyl phosphate or any other suitable physiologically acceptable derivative of ascorbic acid.
5. A composition according to any of Claims 1 to 4, containing a tocopheryl derivative.
6. A composition according to any of Claims 1 to 5, containing kojic acid.
7. A composition according to any of Claims 1 to 6, containing from about 0.1 weight-% to about 30 weight-% of purified flavonoid, or a plant extract containing an equivalent quantity of flavonoid.
8. A composition according to any of Claims 1 to 7, containing from about 0.1 weight-% to about 5 weight-% of ascorbic acid or of a derivative thereof.
9. A composition according to any of Claims 1 to 8, containing from about 1 to 10 weight-% of a sun filter.
10. A composition according to any of Claims 1 to 9, containing from about 0.1 to about 5 weight-% Kojic acid
11. Cosmetic skin brightening compositions for topical application, comprising ascorbic acid or a derivative thereof and a flavonoid, optionally with other components, diluents, cream bases, gel forming agents, substantially as hereinbefore described and with reference to any of the Examples.
12. A composition according to Claim 3, where the plant extract is an extract of licorice (Glycyrrhiza Glabra).
GB9217821A 1991-08-23 1992-08-21 Cosmetic compositions containing vitamin C and a flavonoid Expired - Fee Related GB2259014B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL99291A IL99291A (en) 1991-08-23 1991-08-23 Cosmetic preparations

Publications (3)

Publication Number Publication Date
GB9217821D0 GB9217821D0 (en) 1992-10-07
GB2259014A true GB2259014A (en) 1993-03-03
GB2259014B GB2259014B (en) 1996-02-28

Family

ID=11062833

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9217821A Expired - Fee Related GB2259014B (en) 1991-08-23 1992-08-21 Cosmetic compositions containing vitamin C and a flavonoid

Country Status (9)

Country Link
AU (1) AU654030B2 (en)
CA (1) CA2076467A1 (en)
CH (1) CH684739A5 (en)
DE (1) DE4227806A1 (en)
ES (1) ES2050074B1 (en)
FR (1) FR2680466B3 (en)
GB (1) GB2259014B (en)
IL (1) IL99291A (en)
PT (1) PT100800B (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0716847A1 (en) * 1994-12-13 1996-06-19 Beiersdorf Aktiengesellschaft Cosmetic or dermatologic compositions containing cinnamic acid derivatives and a flavonoid
FR2736263A1 (en) * 1995-07-07 1997-01-10 C3D Sarl DEPIGMENTING DERMOCOSMETIC COMPOSITION AND USE THEREOF
FR2745179A1 (en) * 1996-02-28 1997-08-29 Gattefosse Holding Stock mixtures for preparing skin cosmetics
WO1998058628A1 (en) * 1997-06-20 1998-12-30 Mary Kay Inc. Cosmetic composition containing a whitening agent and an exfoliant
US5952391A (en) * 1997-12-13 1999-09-14 Beiersdorf Ag Use of flavones and flavonoids against the UV-induced decomposition of dibenzoylmethane and its derivatives
WO1999055352A1 (en) * 1998-04-29 1999-11-04 Avon Products, Inc. Skin whitening composition
WO2000028961A1 (en) * 1998-11-13 2000-05-25 The Procter & Gamble Company A skin lightening composition containing an ascorbic acid compound
WO2000028960A1 (en) * 1998-11-13 2000-05-25 The Procter & Gamble Company An oil-in-water emulsion containing an ascorbic acid compound
FR2787710A1 (en) * 1998-12-29 2000-06-30 Clarins Cosmetic composition useful for lightening skin color comprises melanogenesis-inhibiting parsley and chamomile extracts
EP1147764A2 (en) * 2000-04-19 2001-10-24 Nof Corporation Cosmetic composition
EP1210077A1 (en) * 1999-06-15 2002-06-05 Benjamin D. Gordon Compositions and systems for the treatment of hyperpigmentation
US6436374B1 (en) * 1997-11-12 2002-08-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Light-stable cosmetic formulation containing butylmethoxydibenzoylmethane
US6521668B2 (en) * 1999-12-14 2003-02-18 Avon Products, Inc. Cosmetic composition and methods of use
WO2005074880A1 (en) * 2004-01-30 2005-08-18 Access Business Group International Llc. Holistic composition and method for reducing skin pigmentation
WO2005094770A1 (en) * 2004-03-30 2005-10-13 Unilever Plc Skin lightening compositions comprising vitamines and flavonoids
US7189759B2 (en) 2001-05-23 2007-03-13 Medicis Pharmaceutical Corporation Compositions for the treatment of pigmentation disorders and methods for their manufacture
WO2008098649A1 (en) * 2007-02-13 2008-08-21 Beiersdorf Ag Method for depigmenting the skin
US7452549B2 (en) 2000-10-24 2008-11-18 Nestec S.A. Synergistic antioxidant combination of delta tocols and polyphenols
CN103491863A (en) * 2011-02-28 2014-01-01 株式会社爱茉莉太平洋 Method for calculating a thermal protection factor
WO2014188276A3 (en) * 2013-04-22 2015-05-28 Neocutis Sa Antioxidant compositions and methods of using the same
EP2444061A4 (en) * 2009-06-17 2015-08-05 Kao Corp Apigenin-containing composition
CN105125418A (en) * 2014-05-31 2015-12-09 尹连花 Skin care and speckle reduction cream preparation and preparation method thereof
WO2017071821A1 (en) * 2015-10-30 2017-05-04 The Boots Company Plc Skin care composition and method thereof

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2904628B2 (en) * 1991-12-19 1999-06-14 同和鉱業株式会社 Fair skin
FR2708851B1 (en) * 1993-08-12 1995-09-22 Oreal Cosmetic composition comprising the combination of a nanopigment of metal oxides and an antioxidant, and its use for the protection of the skin and hair.
IL109012A (en) * 1994-03-17 1998-09-24 Fischer Pharma Ltd Skin whitening composition comprising glycyrrhyza glabra and hydroxy acids
FR2723316B1 (en) * 1994-08-04 1996-10-04 Thorel Jean Noel SKIN DEPIGMENTING COMPOSITIONS AND PREPARATIONS FOR PHARMACEUTICAL OR COSMETIC USES
FR2735688B1 (en) * 1995-06-26 1997-08-14 Oreal USE IN COMBINATION OF AN ALPHA-HYDROXYACID AND A TITANIUM OXIDE FOR SKIN WHITENING
FR2736829B1 (en) * 1995-07-20 1997-09-12 Oreal COMPOSITION FOR FIGHTING AGAINST SPOTS AND / OR AGING OF THE SKIN, USES THEREOF
FR2746008B1 (en) * 1996-03-14 1998-05-29 COMPOSITION FOR TOPICAL USE ANTI-AGING
US6162419A (en) * 1996-11-26 2000-12-19 Nicholas V. Perricone Stabilized ascorbyl compositions
DE19807774A1 (en) * 1998-02-24 1999-08-26 Beiersdorf Ag Use of flavone, flavanone or flavonoid compound for protection of ascorbic acid or ascorbyl compound against oxidation, especially in cosmetic and dermatological preparations,
DE19845319A1 (en) * 1998-10-01 2000-04-06 Beiersdorf Ag Use of mono-, oligo- and polymeric ethers, esters and ether-ester surfactants for stabilizing flavone, flavanone and/or flavonoid useful in cosmetic and dermatological formulations
DE19845322A1 (en) * 1998-10-01 2000-04-06 Beiersdorf Ag Active combination based on flavone, flavanone and/or flavonoid, useful in cosmetic and dermatological formulations, contains 2-tert.-butyl hydroquinone
DE19845266A1 (en) * 1998-10-01 2000-04-06 Beiersdorf Ag Use of butylhydroxytoluene for stabilizing flavone, flavanone and/or flavonoid useful in cosmetic and dermatological formulations
US5980904A (en) * 1998-11-18 1999-11-09 Amway Corporation Skin whitening composition containing bearberry extract and a reducing agent
DE19923713A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Cosmetic or dermatological sunscreen preparations containing flavone derivatives and / or flavanone derivatives, in particular flavonoids and benzotriazole, and the use of UV filter substances having the structural motif of benzotriazole for stabilizing flavone derivatives and / or flavanone derivatives, in particular flavonoids
DE19923715A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Cosmetic or dermatological sunscreen preparations containing flavone derivatives and / or flavanone derivatives, in particular flavonoids and s-triazine, and the use of UV filter substances having the structural motif of s-triazine for stabilizing flavone derivatives and / or flavanone derivatives, in particular flavonoids
DE19923712A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Active substance combination of sulfonated UV filter substances and flavone derivatives and / or flavanone derivatives, in particular flavonoids, and cosmetic preparations containing such active substance combinations
DE19925499A1 (en) * 1999-06-04 2000-12-07 Beiersdorf Ag Use of ascorbic acid and one or more flavone derivatives and / or flavonone derivatives, in particular flavonoids, for the preparation of cosmetic or dermatological preparations for the prophylaxis or relief of sunburn
GB9917103D0 (en) 1999-07-22 1999-09-22 Secr Defence Barrier cream
GB9917729D0 (en) 1999-07-28 1999-09-29 Boots Co Plc Hair care composition
FR2816502B1 (en) * 2000-11-10 2003-04-11 Oreal COSMETIC COMPOSITION CONSISTING OF AN AMINOPHENOL DERIVATIVE AND AN ISOFLAVONOIDE
JP2002212054A (en) * 2001-01-16 2002-07-31 Tsumura & Co Bathing agent composition
FR2820973B1 (en) * 2001-02-19 2003-05-23 Oreal COMPOSITION COMPRISING VITAMIN C PREPARED DURING APPLICATION, USE OF ENZYMES FOR THE FORMATION OF VITAMIN C FOR TOPICAL USE AND COSMETIC PROCESSING METHOD
US6436378B1 (en) * 2001-02-28 2002-08-20 Colgate-Palmolive Company Composition
WO2003039502A1 (en) * 2001-11-09 2003-05-15 Beiersdorf Ag Cosmetic and/or dermatological preparation containing octadecene dicarboxylic acid and uv filtering substances
DE10215342A1 (en) * 2002-03-28 2003-10-23 Coty Bv Skin lightening cosmetic
US6844014B1 (en) 2002-07-22 2005-01-18 Stephen Rafkin Herbal healing lotion for veterinary use
DE10238449A1 (en) * 2002-08-22 2004-03-04 Beiersdorf Ag Cosmetic and / or dermatological preparation
AU2004296694C1 (en) * 2003-12-15 2011-05-19 Kuraray Co., Ltd. External preparations for skin
DE102004042299A1 (en) 2004-08-27 2006-03-23 Lancaster Group Gmbh Cosmetic brightening and cleansing agent for skin, comprises complex of plant extract, and conventional cosmetic carriers, additives and other active substances
ES2255862B1 (en) * 2004-12-27 2007-07-16 Sesderma, S.L. ADDITIVES FOR CUTANEOUS PEELINGS.
FR2884250B1 (en) * 2005-04-06 2010-01-08 Coletica USE OF AURONES FOR THE DEPIGMENTING OR INHIBITING ACTIVITY OF MELANOGENESIS IN COSMETIC OR DERMATOLOGICAL COMPOSITIONS
JP2006290886A (en) * 2005-04-06 2006-10-26 Engelhard Lyon Sa Cosmetic depigmentation care method comprising applying at least one auron
DE102013208865A1 (en) * 2013-05-14 2014-11-20 Beiersdorf Ag Stabilized preparations containing ascorbic acid and phosphate ions
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
FR3007981B1 (en) * 2013-07-05 2016-01-22 Oreal ASSOCIATION OF EXTRACT OF HAMAMELIS VIRGINIANA, ESCIN, AND ASCORBIC ACID
DE102014211185A1 (en) 2014-06-11 2015-12-17 Henkel Ag & Co. Kgaa Cosmetic compositions for skin lightening

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668516A (en) * 1983-03-30 1987-05-26 Alain Duraffourd Composition for regenerating the collagen of connective skin tissue and a process for its preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582941B3 (en) * 1985-06-11 1987-10-09 Moreau Lavaud Reine COSMETIC COMPOSITION BASED ON EXTRACTS OF MURIER LEAVES
JPS6360911A (en) * 1986-09-01 1988-03-17 Riyuuhoudou Seiyaku Kk Ascorbic acid-containing composition
FR2616328B1 (en) * 1987-06-12 1990-03-02 Moet Hennessy Rech COMPOSITION BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING MURIER EXTRACT, OR AT LEAST ONE FLAVONE, PARTICULARLY A KUWANONE AND PHARMACEUTICAL COMPOSITION, ESPECIALLY DERMATOLOGICAL, WITH DEPIGMENTARY, OR ANTI-INFLAMMENT ACTIVITY, OR ANTI-INFLAMENT,
JPH0278611A (en) * 1988-09-13 1990-03-19 Kansai Paint Co Ltd Skin cleaning agent
GB8910366D0 (en) * 1989-05-05 1989-06-21 Unilever Plc Skin composition
TW197375B (en) * 1990-11-19 1993-01-01 Hayashibara Biochem Lab

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668516A (en) * 1983-03-30 1987-05-26 Alain Duraffourd Composition for regenerating the collagen of connective skin tissue and a process for its preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RIV. ITALE. ESSENZE. COSMET. 61(1), PAGES 2-9 *

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121243A (en) * 1994-12-13 2000-09-19 Beiersdorf Ag Treatment of skin with a formulation comprising alpha-glucosyl rutin and one or more cinnamic acid derivatives
WO1996018381A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides
WO1996018380A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Use of flavonoids for protecting unstable cosmetic active substances and constituents in cosmetic and dermatological formulations
WO1996018382A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Use of flavonoids as immunomodulating or immuno-protective agents in cosmetic and dermatological preparations
WO1996018379A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Cosmetic and dermatological preparations with flavonoids
US6423747B1 (en) 1994-12-13 2002-07-23 Beiersdorf Ag Cosmetic and dermatological preparations with flavonoids
US6562794B1 (en) 1994-12-13 2003-05-13 Beiersdorf Ag Cosmetic and dermatological formulations comprising flavonoids
EP0716847A1 (en) * 1994-12-13 1996-06-19 Beiersdorf Aktiengesellschaft Cosmetic or dermatologic compositions containing cinnamic acid derivatives and a flavonoid
US6596761B2 (en) 1994-12-13 2003-07-22 Beiersdorf Ag Cosmetic and dermatological preparation with flavonoids
US6180662B1 (en) 1994-12-13 2001-01-30 Beiersdorf Ag Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides
WO1997002807A1 (en) * 1995-07-07 1997-01-30 C 3 D Depigmenting cosmetic skin-care composition and use thereof
US6190664B1 (en) * 1995-07-07 2001-02-20 C 3 D Depigmenting cosmetic skin-care composition and use thereof
FR2736263A1 (en) * 1995-07-07 1997-01-10 C3D Sarl DEPIGMENTING DERMOCOSMETIC COMPOSITION AND USE THEREOF
FR2745179A1 (en) * 1996-02-28 1997-08-29 Gattefosse Holding Stock mixtures for preparing skin cosmetics
WO1998058628A1 (en) * 1997-06-20 1998-12-30 Mary Kay Inc. Cosmetic composition containing a whitening agent and an exfoliant
US6436374B1 (en) * 1997-11-12 2002-08-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Light-stable cosmetic formulation containing butylmethoxydibenzoylmethane
US5952391A (en) * 1997-12-13 1999-09-14 Beiersdorf Ag Use of flavones and flavonoids against the UV-induced decomposition of dibenzoylmethane and its derivatives
WO1999055352A1 (en) * 1998-04-29 1999-11-04 Avon Products, Inc. Skin whitening composition
WO2000028961A1 (en) * 1998-11-13 2000-05-25 The Procter & Gamble Company A skin lightening composition containing an ascorbic acid compound
WO2000028960A1 (en) * 1998-11-13 2000-05-25 The Procter & Gamble Company An oil-in-water emulsion containing an ascorbic acid compound
FR2787710A1 (en) * 1998-12-29 2000-06-30 Clarins Cosmetic composition useful for lightening skin color comprises melanogenesis-inhibiting parsley and chamomile extracts
EP1210077A1 (en) * 1999-06-15 2002-06-05 Benjamin D. Gordon Compositions and systems for the treatment of hyperpigmentation
EP1210077A4 (en) * 1999-06-15 2002-12-18 Benjamin D Gordon Compositions and systems for the treatment of hyperpigmentation
US6521668B2 (en) * 1999-12-14 2003-02-18 Avon Products, Inc. Cosmetic composition and methods of use
EP1147764A3 (en) * 2000-04-19 2002-03-20 Nof Corporation Cosmetic composition
EP1147764A2 (en) * 2000-04-19 2001-10-24 Nof Corporation Cosmetic composition
US7452549B2 (en) 2000-10-24 2008-11-18 Nestec S.A. Synergistic antioxidant combination of delta tocols and polyphenols
US7189759B2 (en) 2001-05-23 2007-03-13 Medicis Pharmaceutical Corporation Compositions for the treatment of pigmentation disorders and methods for their manufacture
US7429391B2 (en) 2004-01-30 2008-09-30 Access Business Group International Llc Holistic composition and method for reducing skin pigmentation
WO2005074880A1 (en) * 2004-01-30 2005-08-18 Access Business Group International Llc. Holistic composition and method for reducing skin pigmentation
WO2005094770A1 (en) * 2004-03-30 2005-10-13 Unilever Plc Skin lightening compositions comprising vitamines and flavonoids
WO2008098649A1 (en) * 2007-02-13 2008-08-21 Beiersdorf Ag Method for depigmenting the skin
EP2444061A4 (en) * 2009-06-17 2015-08-05 Kao Corp Apigenin-containing composition
CN103491863A (en) * 2011-02-28 2014-01-01 株式会社爱茉莉太平洋 Method for calculating a thermal protection factor
CN103491863B (en) * 2011-02-28 2015-11-25 株式会社爱茉莉太平洋 For calculating the method for thermal protection factor
WO2014188276A3 (en) * 2013-04-22 2015-05-28 Neocutis Sa Antioxidant compositions and methods of using the same
US9713604B2 (en) 2013-04-22 2017-07-25 Anteis Sa Antioxidant compositions and methods of using the same
CN105125418A (en) * 2014-05-31 2015-12-09 尹连花 Skin care and speckle reduction cream preparation and preparation method thereof
WO2017071821A1 (en) * 2015-10-30 2017-05-04 The Boots Company Plc Skin care composition and method thereof

Also Published As

Publication number Publication date
AU654030B2 (en) 1994-10-20
CA2076467A1 (en) 1993-02-24
IL99291A (en) 1997-04-15
CH684739A5 (en) 1994-12-15
ES2050074B1 (en) 1994-12-16
ES2050074A1 (en) 1994-05-01
FR2680466B3 (en) 1993-11-19
GB9217821D0 (en) 1992-10-07
DE4227806A1 (en) 1993-02-25
PT100800B (en) 1999-07-30
FR2680466A1 (en) 1993-02-26
PT100800A (en) 1994-02-28
AU2122092A (en) 1993-02-25
IL99291A0 (en) 1992-07-15
GB2259014B (en) 1996-02-28

Similar Documents

Publication Publication Date Title
GB2259014A (en) Compositions containing flavonoids
USRE38623E1 (en) Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use
EP0945128B1 (en) Use of flavones, flavanones, or flavonoides for the protection of ascorbic acid and/or ascorbylbonds against oxidation
EP0799020A1 (en) Cosmetic and dermatological preparations with flavonoids
US6436378B1 (en) Composition
KR20060130631A (en) Holistic composition and method for reducing skin pigmentation
US6214352B1 (en) Tyrosinase inhibiting agent
JP2000247866A (en) Skin agent for external use
JPH05306231A (en) Skin external preparation
DE60207026T2 (en) Use of panthenol sulphonic acid and / or its salts as radical scavenger
US20020150601A1 (en) Use of folic acid and/or derivatives thereof for the preparation of cosmetic or dermatological preparations for the prophylaxis of damage to DNA intrinsic to the skin and/or for the repair of existing damage to DNA intrinsic to the skin
KR101511252B1 (en) Compositions comprising Atractyloides japonica rhizome extract and Tranexamic acid for whitening
JP2004131498A (en) External preparation for skin
JP2002370962A (en) Bleaching preparation and cosmetic for preventing and improving aging of skin
KR20130125878A (en) Cosmetic composition for whitening of the skin comprising hydroxamic acid derivatives
JPH0118044B2 (en)
JPH05294819A (en) Beautifying cosmetic
KR100894581B1 (en) Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations
Levy Cosmetics that imitate a tan
CN115177565B (en) Whitening and skin brightening composition and application thereof in cosmetics
JPWO2005084613A1 (en) Skin preparation
EP1338269A1 (en) Composition for whitening the skin and alleviating of pigmentation disorders containing creatinine and/or a creatinine derivative as active ingredient
CN112118825B (en) Topical compositions
JPH04247010A (en) Beautifying and whitening cosmetics
AU2002250193B2 (en) Skin composition

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19990821