GB2118189B - An automatic synthesizer for dna - Google Patents

An automatic synthesizer for dna

Info

Publication number
GB2118189B
GB2118189B GB08305205A GB8305205A GB2118189B GB 2118189 B GB2118189 B GB 2118189B GB 08305205 A GB08305205 A GB 08305205A GB 8305205 A GB8305205 A GB 8305205A GB 2118189 B GB2118189 B GB 2118189B
Authority
GB
United Kingdom
Prior art keywords
dna
automatic synthesizer
synthesizer
automatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08305205A
Other versions
GB8305205D0 (en
GB2118189A (en
Inventor
Tohru Fuwa
Kenichi Miyoshi
Yoshiaki Ohsugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Wakunaga Pharmaceutical Co Ltd
Original Assignee
Shimadzu Corp
Wakunaga Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP57030887A priority Critical patent/JPS6311360B2/ja
Priority to JP57030889A priority patent/JPS6121639B2/ja
Priority to JP3088882A priority patent/JPS6241676B2/ja
Priority to JP3991782A priority patent/JPS6241677B2/ja
Application filed by Shimadzu Corp, Wakunaga Pharmaceutical Co Ltd filed Critical Shimadzu Corp
Publication of GB8305205D0 publication Critical patent/GB8305205D0/en
Publication of GB2118189A publication Critical patent/GB2118189A/en
Application granted granted Critical
Publication of GB2118189B publication Critical patent/GB2118189B/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00286Reactor vessels with top and bottom openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00389Feeding through valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00423Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00695Synthesis control routines, e.g. using computer programs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL CHEMISTRY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL CHEMISTRY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
GB08305205A 1982-02-26 1983-02-24 An automatic synthesizer for dna Expired GB2118189B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP57030887A JPS6311360B2 (en) 1982-02-26 1982-02-26
JP57030889A JPS6121639B2 (en) 1982-02-26 1982-02-26
JP3088882A JPS6241676B2 (en) 1982-02-26 1982-02-26
JP3991782A JPS6241677B2 (en) 1982-03-12 1982-03-12

Publications (3)

Publication Number Publication Date
GB8305205D0 GB8305205D0 (en) 1983-03-30
GB2118189A GB2118189A (en) 1983-10-26
GB2118189B true GB2118189B (en) 1985-05-15

Family

ID=27459338

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08305205A Expired GB2118189B (en) 1982-02-26 1983-02-24 An automatic synthesizer for dna

Country Status (3)

Country Link
CA (1) CA1199776A (en)
DE (1) DE3306770A1 (en)
GB (1) GB2118189B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659983B2 (en) 2003-01-22 2010-02-09 Electronics And Telecommunications Resarch Institute Hybrid random bead/chip based microarray
US7791802B2 (en) 2004-02-19 2010-09-07 Illumina, Inc. Optical identification element having a non-waveguide substrate
US7796333B2 (en) 2004-11-17 2010-09-14 Illumina, Inc. Encoded microparticles and a method for fabricating
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7898735B2 (en) 2002-09-12 2011-03-01 Illumina, Inc. Methods and systems for writing an optical code within or on a fiber substrate
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
US8470605B2 (en) 2002-09-12 2013-06-25 Illumina, Inc. Optical reader for reading encoded microparticles
US8498052B2 (en) 2002-08-20 2013-07-30 Illumina, Inc. Composition including an item and an encoded optical substrate and a method for identifying an item

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (en) * 1983-04-19 1987-11-27 California Inst Of Techn improved installation and process for the synthesis of chemical compounds, particularly oligonucleotides
JPS6054398A (en) * 1983-09-02 1985-03-28 Nippon Zeon Co Ltd Polynucleotide synthesizer
JPS6130597A (en) * 1984-07-20 1986-02-12 Nippon Zeon Co Ltd Device for synthesizing polynucleotide
WO1992020824A1 (en) * 1991-05-24 1992-11-26 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
US5368823A (en) * 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
WO2001090225A1 (en) * 2000-05-22 2001-11-29 Kabushiki Kaisya Advance Novel method for forming polymer pattern
WO2007065807A2 (en) * 2005-12-06 2007-06-14 F. Hoffmann-La Roche Ag Automated solid phase synthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
JPS4820995B1 (en) * 1968-07-08 1973-06-25
FR2485003B1 (en) * 1980-06-23 1985-05-10 Clin Midy

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8333325B2 (en) 2002-08-20 2012-12-18 Illumina, Inc. Optical reader system for substrates having an optically readable code
US8614852B2 (en) 2002-08-20 2013-12-24 Illumina, Inc. Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light
US8498052B2 (en) 2002-08-20 2013-07-30 Illumina, Inc. Composition including an item and an encoded optical substrate and a method for identifying an item
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7898735B2 (en) 2002-09-12 2011-03-01 Illumina, Inc. Methods and systems for writing an optical code within or on a fiber substrate
US8470605B2 (en) 2002-09-12 2013-06-25 Illumina, Inc. Optical reader for reading encoded microparticles
US7843567B2 (en) 2003-01-22 2010-11-30 Illumina, Inc. Methods of identifying an analyte and nucleic acid analysis
US8049893B2 (en) 2003-01-22 2011-11-01 Illumina, Inc. Methods of identifying analytes and using encoded particles
US7659983B2 (en) 2003-01-22 2010-02-09 Electronics And Telecommunications Resarch Institute Hybrid random bead/chip based microarray
US9268983B2 (en) 2003-01-22 2016-02-23 Illumina, Inc. Optical system and method for reading encoded microbeads
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
US8565475B2 (en) 2003-08-20 2013-10-22 Illumina, Inc. Optical system and method for reading encoded microbeads
US7791802B2 (en) 2004-02-19 2010-09-07 Illumina, Inc. Optical identification element having a non-waveguide substrate
US7796333B2 (en) 2004-11-17 2010-09-14 Illumina, Inc. Encoded microparticles and a method for fabricating
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time

Also Published As

Publication number Publication date
CA1199776A1 (en)
GB8305205D0 (en) 1983-03-30
DE3306770A1 (en) 1983-09-15
CA1199776A (en) 1986-01-28
GB2118189A (en) 1983-10-26

Similar Documents

Publication Publication Date Title
GB2122586B (en) Dispensing-closures
GB2118200B (en) Microlatexes
DE3380308D1 (en) Process for cell modification
GB2128984B (en) Diaza-bicyclic compounds
DE3373544D1 (en) Automatic analytical apparatus
GB2130553B (en) Integral reagent despenser
CS750083A2 (en) Zpusob vyroby zesitovaneho kopolymeru
IE831732L (en) Acylanilide
GB8316159D0 (en) 3-benzylidene-camphors
CS568783A2 (en) Zpusob vyroby vysoce cisteho cefuroximaxetilu
GB8308570D0 (en) Fire-barriers
CS124683A2 (en) Zpusob zapouzdreni ucinne latky chemickeho prostredku
CY1566A (en) N-arylsulfonyl-n-pyrimidinylharnsstoffe
JPS59118163A (en) Automatic syringe
CS810683A2 (en) Zpusob vyroby tetrazolovych derivatu
GB8329897D0 (en) Link-conveytor
IE831101L (en) Azolylmethyloxitanes
DE3366843D1 (en) Device for cross-country-ski
IN159163B (en) Device for determining-glucose
JPS58190763A (en) Plate for micro-titration
GB8530310D0 (en) Antibodies
GB8319605D0 (en) Assay method
JPS5714339A (en) Blunt-hook for operation
NZ204056A (en) System for biological cell selection
GB8330690D0 (en) Tool for exodontia

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19990224