GB2052971A - Combating swine dysentery with aspergillic acid - Google Patents
Combating swine dysentery with aspergillic acid Download PDFInfo
- Publication number
- GB2052971A GB2052971A GB7924003A GB7924003A GB2052971A GB 2052971 A GB2052971 A GB 2052971A GB 7924003 A GB7924003 A GB 7924003A GB 7924003 A GB7924003 A GB 7924003A GB 2052971 A GB2052971 A GB 2052971A
- Authority
- GB
- United Kingdom
- Prior art keywords
- swine
- substituted pyrazine
- feed
- dysentery
- commestible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000282898 Sus scrofa Species 0.000 title claims description 28
- 208000001848 dysentery Diseases 0.000 title claims description 17
- IUZCDJYHMMWBBE-VIFPVBQESA-N 6-[(2S)-butan-2-yl]-1-hydroxy-3-(2-methylpropyl)pyrazin-2-one Chemical compound CC[C@H](C)C1=CN=C(CC(C)C)C(=O)N1O IUZCDJYHMMWBBE-VIFPVBQESA-N 0.000 title 1
- 238000011282 treatment Methods 0.000 claims description 20
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims description 7
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 7
- 150000003216 pyrazines Chemical class 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 238000011321 prophylaxis Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 238000010790 dilution Methods 0.000 claims description 3
- 239000012895 dilution Substances 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims 3
- 230000003000 nontoxic effect Effects 0.000 claims 3
- 235000013361 beverage Nutrition 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 15
- 230000037396 body weight Effects 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 239000010865 sewage Substances 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 241000700159 Rattus Species 0.000 description 7
- 230000002496 gastric effect Effects 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 230000007059 acute toxicity Effects 0.000 description 6
- 231100000403 acute toxicity Toxicity 0.000 description 6
- 230000007665 chronic toxicity Effects 0.000 description 6
- 231100000160 chronic toxicity Toxicity 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 108010082126 Alanine transaminase Proteins 0.000 description 4
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000007912 intraperitoneal administration Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 241000607626 Vibrio cholerae Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 230000036244 malformation Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 231100000456 subacute toxicity Toxicity 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 229940118696 vibrio cholerae Drugs 0.000 description 3
- 208000031648 Body Weight Changes Diseases 0.000 description 2
- 241000589893 Brachyspira hyodysenteriae Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000004579 body weight change Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 244000144980 herd Species 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000011886 postmortem examination Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000589877 Campylobacter coli Species 0.000 description 1
- 206010012741 Diarrhoea haemorrhagic Diseases 0.000 description 1
- MVTQIFVKRXBCHS-SMMNFGSLSA-N N-[(3S,6S,12R,15S,16R,19S,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone Chemical compound CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C)n2.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1 MVTQIFVKRXBCHS-SMMNFGSLSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 241000589970 Spirochaetales Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 239000004188 Virginiamycin Substances 0.000 description 1
- 108010080702 Virginiamycin Proteins 0.000 description 1
- 231100000369 acute toxicity data Toxicity 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- XKNKHVGWJDPIRJ-UHFFFAOYSA-N arsanilic acid Chemical compound NC1=CC=C([As](O)(O)=O)C=C1 XKNKHVGWJDPIRJ-UHFFFAOYSA-N 0.000 description 1
- 229950002705 arsanilic acid Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 229960000427 carbadox Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
- 229960001625 furazolidone Drugs 0.000 description 1
- 208000027909 hemorrhagic diarrhea Diseases 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- BPMVRAQIQQEBLN-OBPBNMOMSA-N methyl n-[(e)-(1-hydroxy-4-oxidoquinoxalin-4-ium-2-ylidene)methyl]iminocarbamate Chemical compound C1=CC=C2N(O)C(=C/N=NC(=O)OC)/C=[N+]([O-])C2=C1 BPMVRAQIQQEBLN-OBPBNMOMSA-N 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- 235000019373 virginiamycin Nutrition 0.000 description 1
- 229960003842 virginiamycin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7924003A GB2052971A (en) | 1979-07-10 | 1979-07-10 | Combating swine dysentery with aspergillic acid |
| EP80103047A EP0022173A1 (en) | 1979-07-10 | 1980-05-31 | Pyrazine derivative for use in, and swine feed compositions containing it |
| AU58973/80A AU5897380A (en) | 1979-07-10 | 1980-06-02 | Pyrazines used to combat swine dysentery |
| ZA00803278A ZA803278B (en) | 1979-07-10 | 1980-06-02 | Products and method for combating swine dysentery |
| US06/157,100 US4292318A (en) | 1979-07-10 | 1980-06-06 | Product and method for combating swine dysentery |
| JP8530380A JPS5612374A (en) | 1979-07-10 | 1980-06-25 | Drug active to hog dysentery |
| DK274380A DK274380A (da) | 1979-07-10 | 1980-06-26 | Produkter og fremgangsmaade til bekaempelse af svinedysenteri |
| GR62327A GR69203B (https=) | 1979-07-10 | 1980-07-01 | |
| PT71515A PT71515A (en) | 1979-07-10 | 1980-07-08 | Process for preparing compositions for combatting swine dysentery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7924003A GB2052971A (en) | 1979-07-10 | 1979-07-10 | Combating swine dysentery with aspergillic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2052971A true GB2052971A (en) | 1981-02-04 |
Family
ID=10506415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7924003A Withdrawn GB2052971A (en) | 1979-07-10 | 1979-07-10 | Combating swine dysentery with aspergillic acid |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4292318A (https=) |
| EP (1) | EP0022173A1 (https=) |
| JP (1) | JPS5612374A (https=) |
| AU (1) | AU5897380A (https=) |
| DK (1) | DK274380A (https=) |
| GB (1) | GB2052971A (https=) |
| GR (1) | GR69203B (https=) |
| PT (1) | PT71515A (https=) |
| ZA (1) | ZA803278B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573188A (en) * | 1989-01-27 | 1996-11-12 | Coatex S.A. | Process for grinding calcium carbonate in aqueous media |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720768A (en) * | 1971-11-22 | 1973-03-13 | Abbott Lab | Aspergillic acid as an antihypertensive agent |
-
1979
- 1979-07-10 GB GB7924003A patent/GB2052971A/en not_active Withdrawn
-
1980
- 1980-05-31 EP EP80103047A patent/EP0022173A1/en not_active Withdrawn
- 1980-06-02 ZA ZA00803278A patent/ZA803278B/xx unknown
- 1980-06-02 AU AU58973/80A patent/AU5897380A/en not_active Abandoned
- 1980-06-06 US US06/157,100 patent/US4292318A/en not_active Expired - Lifetime
- 1980-06-25 JP JP8530380A patent/JPS5612374A/ja active Pending
- 1980-06-26 DK DK274380A patent/DK274380A/da unknown
- 1980-07-01 GR GR62327A patent/GR69203B/el unknown
- 1980-07-08 PT PT71515A patent/PT71515A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5612374A (en) | 1981-02-06 |
| AU5897380A (en) | 1981-03-19 |
| ZA803278B (en) | 1981-04-29 |
| DK274380A (da) | 1981-01-11 |
| PT71515A (en) | 1980-08-01 |
| EP0022173A1 (en) | 1981-01-14 |
| US4292318A (en) | 1981-09-29 |
| GR69203B (https=) | 1982-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |