GB2026870B - Body-implantable pacemaker - Google Patents

Body-implantable pacemaker

Info

Publication number
GB2026870B
GB2026870B GB7925328A GB7925328A GB2026870B GB 2026870 B GB2026870 B GB 2026870B GB 7925328 A GB7925328 A GB 7925328A GB 7925328 A GB7925328 A GB 7925328A GB 2026870 B GB2026870 B GB 2026870B
Authority
GB
Grant status
Grant
Patent type
Prior art keywords
output
counter
counts
external
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7925328A
Other versions
GB2026870A (en )
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37252Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
    • A61N1/37264Changing the program; Upgrading firmware
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/368Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/37Monitoring; Protecting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/08Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A61N2001/083Monitoring integrity of contacts, e.g. by impedance measurement

Abstract

A multi-mode pacemaker includes a microprocessor 100 and a memory 102 programmable with a variety of processes for stimulating a heart and/or a sensing and transmitting to an external device conditions of the heart or pacemaker. The microprocessor controls a multiplexer 106 to input via a scaling amplifier and a/d converter 108 signals from atrial and ventricular leads 17, 19, the power source 126, a reed switch 23 operable by an external magnet, or redundant leads on lines 138d,e. The output comprises latch drivers 134 a-d with respective output select switches 130 a-d selectively operable to supply stimulation pulses to the leads or allow sensing. External apparatus 104 may transmit coded information to change the stored program or operation of the reed switch may select a different program starting address. Pulse width, rate and amplitude may be controlled in response to sensed heart activity or power source level and different pacing modes (demand, asynchronous, etc.) or multi-site pacing to disrupt arrhythmias may be selected automatically or externally. In an aid converter 308 (Figure 8), counter 400 counts up the output of VCO 402 controlled by unknown signal V(X) and then counts down to zero the output of VCO 402 then controlled by reference EREF and during such countdown a counter 412 counts clock pulses so that when counter 400 reaches zero the output of counter 412 depends on V(X) but not on the scale factor of VCO 402. <IMAGE>
GB7925328A 1978-07-20 1979-07-20 Body-implantable pacemaker Expired GB2026870B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US92630378 true 1978-07-20 1978-07-20

Publications (2)

Publication Number Publication Date
GB2026870A true GB2026870A (en) 1980-02-13
GB2026870B true GB2026870B (en) 1982-12-15

Family

ID=25453021

Family Applications (2)

Application Number Title Priority Date Filing Date
GB7925328A Expired GB2026870B (en) 1978-07-20 1979-07-20 Body-implantable pacemaker
GB8127414A Expired GB2079610B (en) 1978-07-20 1979-07-20 Body-implantable electromedical apparatus

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8127414A Expired GB2079610B (en) 1978-07-20 1979-07-20 Body-implantable electromedical apparatus

Country Status (5)

Country Link
JP (1) JPS6241032B2 (en)
DE (2) DE2954642C2 (en)
FR (2) FR2431296B1 (en)
GB (2) GB2026870B (en)
NL (1) NL7905649A (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8150508B2 (en) 2006-03-29 2012-04-03 Catholic Healthcare West Vagus nerve stimulation method
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8452387B2 (en) 2010-09-16 2013-05-28 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8725239B2 (en) 2011-04-25 2014-05-13 Cyberonics, Inc. Identifying seizures using heart rate decrease
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7907462A (en) * 1978-10-30 1980-05-02 Medtronic Inc A heart pacemaker.
US4273132A (en) * 1978-11-06 1981-06-16 Medtronic, Inc. Digital cardiac pacemaker with threshold margin check
US4230120A (en) * 1978-11-06 1980-10-28 Medtronic, Inc. Energy compensation means for digital cardiac pacemaker
CA1136716A (en) * 1978-11-06 1982-11-30 Ray S. Mcdonald Battery monitor update at each pacemaker pulse
EP0011935B2 (en) * 1978-11-06 1991-05-22 Medtronic, Inc. Body stimulator programmer
US4295474A (en) * 1979-10-02 1981-10-20 The Johns Hopkins University Recorder with patient alarm and service request systems suitable for use with automatic implantable defibrillator
US4278094A (en) * 1979-10-10 1981-07-14 Medtronic, Inc. Pacemaker with pulse width adjustment circuitry
US4284082A (en) * 1979-12-12 1981-08-18 Medtronic B.V.Kerkrade Ventricular synchronized atrial pacemaker and method of operation
US4388927A (en) * 1979-12-13 1983-06-21 American Hospital Supply Corporation Programmable digital cardiac pacer
FR2471789B1 (en) * 1979-12-18 1985-03-08 Cardiofrance Co
DE3172870D1 (en) * 1980-04-07 1985-12-19 Medtronic Inc Demand pacemaker with output pulse artifact rejection
US4343311A (en) * 1980-04-30 1982-08-10 Medtronic, Inc. Atrial refractory control for R-wave rejection in pacemakers
DE3038856A1 (en) * 1980-10-10 1982-05-27 Siemens Ag Pacemaker
JPH0214067B2 (en) * 1980-10-14 1990-04-06 Medtronic Inc
FR2492552A1 (en) * 1980-10-16 1982-04-23 Ela Medical Sa A control device for implantable medical instrument such as a pacemaker and pacemaker comprising this device
FR2492262B1 (en) * 1980-10-16 1987-02-20 Ela Medical Sa Method and device for controlling an apparatus or instrument including an implantable pacemaker
DE3153780C2 (en) * 1980-10-16 2003-04-03 Ela Medical Sa Implantable cardiac pacemaker control system
US4485818A (en) * 1980-11-14 1984-12-04 Cordis Corporation Multi-mode microprocessor-based programmable cardiac pacer
US4374382A (en) * 1981-01-16 1983-02-15 Medtronic, Inc. Marker channel telemetry system for a medical device
US4363325A (en) * 1981-01-19 1982-12-14 Medtronic, Inc. Mode adaptive pacer
DE3270708D1 (en) * 1981-02-17 1986-05-28 Medtronic Inc Implantable medical device power source depletion indicators
WO1982002836A1 (en) * 1981-02-18 1982-09-02 Mirowski Mieczyslaw Externally programmable,implantable heart stimulator
EP0064940B1 (en) * 1981-05-04 1988-05-04 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Cardiac pacemaker
EP0077809B1 (en) * 1981-05-04 1987-11-11 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Pacemaker
EP0077806B1 (en) * 1981-05-04 1989-12-06 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Pacemaker
WO1982003785A1 (en) * 1981-05-04 1982-11-11 Nettelhorst Herwig Pacemaker
EP0077799B1 (en) * 1981-05-04 1987-11-11 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Pacemaker
EP0077801B1 (en) * 1981-05-04 1987-09-23 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Pacemaker
US4404972B1 (en) * 1981-05-18 2000-07-11 Intermedics Inc Implantable device with microprocessor control
US4390022A (en) * 1981-05-18 1983-06-28 Intermedics, Inc. Implantable device with microprocessor control
DE3127597A1 (en) * 1981-07-13 1983-02-17 Siemens Ag A method and a pacemaker for cardiac stimulation bifocal
US4561444A (en) * 1981-08-10 1985-12-31 Cordis Corporation Implantable cardiac pacer having dual frequency programming and bipolar/linipolar lead programmability
DE3175940D1 (en) * 1981-10-26 1987-04-09 Vitafin Nv Programmable cardiac pacemaker
DE3175864D1 (en) * 1981-10-26 1987-02-26 Vitafin Nv Pacemaker utilizing microprocessor dma for generating output pulse sequences
DE3207006A1 (en) * 1982-02-26 1983-09-08 Siemens Ag Av-sequential pacemaker
DE3321839A1 (en) * 1982-06-18 1983-12-22 Biostim Inc Biological electrical stimulator
US4562841A (en) * 1982-08-05 1986-01-07 Cardiac Pacemakers, Inc. Programmable multi-mode cardiac pacemaker
FR2533432B1 (en) * 1982-09-23 1985-01-18 Europ Propulsion
US4467810A (en) * 1982-09-30 1984-08-28 Cordis Corporation Multi-mode microprocessor-based programmable cardiac pacer
US4558702A (en) * 1983-01-21 1985-12-17 Cordis Corporation Cardiac pacer having input/output circuit programmable for use with unipolar and bipolar pacer leads
US4665919A (en) * 1983-03-14 1987-05-19 Vitafin N.V. Pacemaker with switchable circuits and method of operation of same
FR2544988B1 (en) * 1983-04-29 1986-10-10 Ela Medical Sa atrioventricular pacemaker
US4549548A (en) * 1983-09-14 1985-10-29 Vitafin N.V. Pacemaker system with automatic event-programmed switching between unipolar and bipolar operation
US4543963A (en) * 1983-11-22 1985-10-01 Gessman Lawrence J Method and apparatus for differentiating antegrade from retrograde P-waves and for preventing pacemaker generated tachycardia
US4577634A (en) * 1983-11-22 1986-03-25 Gessman Lawrence J Method and apparatus for alleviating paroxysmal atrail tachycardia
US4559947A (en) * 1984-01-27 1985-12-24 Renger Herman L Cardiac tissue stimulator providing P-wave verification, telemetry, marker channels, and antitachycardia capabilities
EP0151689B1 (en) * 1984-02-07 1990-12-27 SCHIAPPARELLI MEDTRONIC S.p.A. Minute ventilation dependent rate responsive pacer
FR2561526A1 (en) * 1984-03-22 1985-09-27 Chaptal Paul Cardiac stimulation method and cardiac stimulator for implementing the method
US4585004A (en) * 1984-06-01 1986-04-29 Cardiac Control Systems, Inc. Heart pacing and intracardiac electrogram monitoring system and associated method
US4587970A (en) * 1985-01-22 1986-05-13 Telectronics N.V. Tachycardia reversion pacer
EP0215730B1 (en) * 1985-09-17 1993-06-16 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Heart stimulator
EP0216725B1 (en) * 1985-09-17 1993-12-01 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Pacemaker
EP0215729B1 (en) * 1985-09-17 1992-12-02 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Heart stimulator
EP0215731B1 (en) * 1985-09-17 1992-12-30 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Heart stimulator
EP0255899B1 (en) * 1986-07-31 1992-07-15 Werner Prof. Dr.-Ing. Irnich Rate adaptive pacemaker
FR2604908B1 (en) * 1986-10-13 1990-06-22 Saint Nicolas Cie Financiere Method for setting up of an implantable pacemaker according to the effort the pacemaker bearer patient implantable pacemaker and external programmer adjustable parameters for controlling an adjustable implantable pacemaker
EP0444021B1 (en) * 1987-11-13 1995-01-25 BIOTRONIK Mess- und Therapiegeräte GmbH &amp; Co Ingenieurbüro Berlin Cardiac pacemaker
US4899750A (en) * 1988-04-19 1990-02-13 Siemens-Pacesetter, Inc. Lead impedance scanning system for pacemakers
DE68921661T2 (en) * 1988-04-19 1995-12-21 Pacesetter Ab Programming the configuration of an implantable pacemaker.
EP0387363B1 (en) * 1989-03-13 1994-06-01 Pacesetter AB Implantable stimulator whose intensity of stimulation of a physiologic event of living beings is adapted to their physical actvity
US5031616A (en) * 1989-12-07 1991-07-16 Siemens-Pacesetter, Inc. Implantable stimulation device having means for self-regulating curent drain usage at battery depletion
US5058581A (en) * 1990-02-20 1991-10-22 Siemens-Pacesetter, Inc. Telemetry apparatus and method for implantable tissue stimulator
US5052389A (en) * 1990-07-26 1991-10-01 Cook Pacemaker Corporation Low-power A/D converter for an implantable medical device and method of use
DE4339304B4 (en) * 1993-11-18 2005-09-15 Robert Bosch Gmbh Circuit arrangement with a transmission member
US5725559A (en) * 1996-05-16 1998-03-10 Intermedics Inc. Programmably upgradable implantable medical device
US6085118A (en) * 1996-07-23 2000-07-04 Pacesetter Ab Implantable multi-electrode device for electrically stimulating a physiological function with automatic selection of housing terminal-to-electrode connection dependent on a sensed signal
DE19724053A1 (en) * 1997-06-07 1998-12-10 Biotronik Mess & Therapieg Electronic storage device, especially for use in implantable medical devices
FR2772622B1 (en) * 1997-12-23 2000-03-31 Ela Medical Sa Implantable medical device active, in particular pacemaker, defibrillator and / or cardioverter, of multisite type configurable
DE102004019391A1 (en) * 2004-04-19 2005-11-03 Endress + Hauser Gmbh + Co. Kg Programmable electronic device
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US8700163B2 (en) 2005-03-04 2014-04-15 Cyberonics, Inc. Cranial nerve stimulation for treatment of substance addiction
US7711419B2 (en) 2005-07-13 2010-05-04 Cyberonics, Inc. Neurostimulator with reduced size
US7840280B2 (en) 2005-07-27 2010-11-23 Cyberonics, Inc. Cranial nerve stimulation to treat a vocal cord disorder
US7489561B2 (en) 2005-10-24 2009-02-10 Cyberonics, Inc. Implantable medical device with reconfigurable non-volatile program
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668690A (en) * 1970-06-08 1972-06-06 Ormond Alfred N Method and apparatus for analog to digital conversion
DE2427800A1 (en) * 1973-06-11 1975-02-20 Gen Electric Analog-to-digital converter
US3825015A (en) * 1972-12-14 1974-07-23 American Optical Corp Single catheter for atrial and ventricular stimulation
NL7700427A (en) * 1976-03-03 1977-09-06 Arco Med Prod Co Implantable digital heart pacemaker, which is provided externally selectable operating parameters.
DE2738871A1 (en) * 1976-09-29 1978-03-30 Arco Med Prod Co Pacemaker
FR2374024A1 (en) * 1976-12-14 1978-07-13 American Hospital Supply Corp Battery operated implanted cardiac stimulator - has signal generator with D=A converter to provide basic signal repetition rate
US4232679B1 (en) * 1977-01-26 1988-05-31

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8738126B2 (en) 2006-03-29 2014-05-27 Catholic Healthcare West Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
US8150508B2 (en) 2006-03-29 2012-04-03 Catholic Healthcare West Vagus nerve stimulation method
US8219188B2 (en) 2006-03-29 2012-07-10 Catholic Healthcare West Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
US8660666B2 (en) 2006-03-29 2014-02-25 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8280505B2 (en) 2006-03-29 2012-10-02 Catholic Healthcare West Vagus nerve stimulation method
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US8306627B2 (en) 2007-04-27 2012-11-06 Cyberonics, Inc. Dosing limitation for an implantable medical device
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8849409B2 (en) 2008-10-24 2014-09-30 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8768471B2 (en) 2008-10-24 2014-07-01 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US9241647B2 (en) 2010-04-29 2016-01-26 Cyberonics, Inc. Algorithm for detecting a seizure from cardiac data
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US9220910B2 (en) 2010-07-30 2015-12-29 Cyberonics, Inc. Seizure detection using coordinate data
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US8948855B2 (en) 2010-09-16 2015-02-03 Flint Hills Scientific, Llc Detecting and validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US8452387B2 (en) 2010-09-16 2013-05-28 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US9020582B2 (en) 2010-09-16 2015-04-28 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8888702B2 (en) 2010-10-01 2014-11-18 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8945006B2 (en) 2010-10-01 2015-02-03 Flunt Hills Scientific, LLC Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8852100B2 (en) 2010-10-01 2014-10-07 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8725239B2 (en) 2011-04-25 2014-05-13 Cyberonics, Inc. Identifying seizures using heart rate decrease
US9498162B2 (en) 2011-04-25 2016-11-22 Cyberonics, Inc. Identifying seizures using heart data from two or more windows
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection

Also Published As

Publication number Publication date Type
JP1433725C (en) grant
GB2079610B (en) 1983-04-07 grant
DE2929498A1 (en) 1980-01-31 application
FR2431296B1 (en) 1984-01-06 grant
FR2431296A1 (en) 1980-02-15 application
NL7905649A (en) 1980-01-22 application
GB2079610A (en) 1982-01-27 application
JPS5521990A (en) 1980-02-16 application
DE2954642C2 (en) 1991-11-07 grant
JPS6241032B2 (en) 1987-09-01 grant
FR2445659A1 (en) 1980-07-25 application
DE2929498C2 (en) 1991-07-11 grant
FR2445659B1 (en) 1985-11-29 grant
GB2026870A (en) 1980-02-13 application

Similar Documents

Publication Publication Date Title
US3311111A (en) Controllable electric body tissue stimulators
US4903701A (en) Oxygen sensing pacemaker
US4236524A (en) Program testing apparatus
US4208008A (en) Pacing generator programming apparatus including error detecting means
US4697591A (en) Cardiac pacer for pacing a human heart and pacing method
US4763655A (en) Frequency-controlled heart pacemaker
US4231027A (en) Battery monitoring means for an implantable living tissue stimulator
US4163451A (en) Interactive method and digitally timed apparatus for cardiac pacing arrhythmia treatment
US4550370A (en) Pacemaker programmer with telemetric functions
US4596255A (en) Apparatus for interpreting and displaying cardiac events of a heart connected to a cardiac pacing means
US5999851A (en) Atrial defibrillation system having patient selectable atrial fibrillation detection
US4567892A (en) Implantable cardiac pacemaker
US4102346A (en) Heart pacemaker monitor, alarm and auxiliary power supply
US4024875A (en) Device for non-invasive programming of implanted body stimulators
US4305397A (en) Pacing generator programmer with transmission checking circuit
US5674249A (en) Atrial defibrillation system having a portable communication device
US6400990B1 (en) Patient activated telemetry control unit using bidirectional asymmetric dual-mode telemetry link to communicate with an implanted device
US4809697A (en) Interactive programming and diagnostic system for use with implantable pacemaker
US4237895A (en) Control signal transmitter and monitor for implanted pacer
US4922907A (en) Method for finding the parameters in a functional relationship between stimulation frequency and load condition sensor signals in a rate responsive heart pacemaker
US4821724A (en) Pacing pulse compensation
US4903700A (en) Pacing pulse compensation
US3757792A (en) Automatic threshold compensating demand pacemaker
US3920024A (en) Threshold tracking system and method for stimulating a physiological system
US4539992A (en) Method and apparatus for communicating with implanted body function stimulator

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930720