GB2012270A - Crystallisation process for sodium cefuroxime - Google Patents

Crystallisation process for sodium cefuroxime

Info

Publication number
GB2012270A
GB2012270A GB7901543A GB7901543A GB2012270A GB 2012270 A GB2012270 A GB 2012270A GB 7901543 A GB7901543 A GB 7901543A GB 7901543 A GB7901543 A GB 7901543A GB 2012270 A GB2012270 A GB 2012270A
Authority
GB
United Kingdom
Prior art keywords
sodium
cefuroxime
sodium cefuroxime
crystalline
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7901543A
Other versions
GB2012270B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB7901543A priority Critical patent/GB2012270B/en
Publication of GB2012270A publication Critical patent/GB2012270A/en
Application granted granted Critical
Publication of GB2012270B publication Critical patent/GB2012270B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Abstract

A process for the preparation of crystalline sodium cefuroxime (the sodium salt of (6R,7R)-3-carbamoyloxymethyl- 7-[(Z)-2-(fur-2-yl)-2- methoxyimino-acetamido]ceph-3-em- 4-carboxylic acid) which comprises adding an aqueous solution of sodium cefuroxime and an aqueous solution containing sodium ions to an aqueous crystallising medium containing a seeding amount of solid sodium cefuroxime and recovering crystalline sodium cefuroxime from the crystalline medium. The process enables the production of crystalline sodium cefuroxime on an industrial scale in a condition of sufficient sterility, purity and solid state stability for use in pharmaceutical preparations.
GB7901543A 1978-01-17 1979-01-16 Crystallisation process Expired GB2012270B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7901543A GB2012270B (en) 1978-01-17 1979-01-16 Crystallisation process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB188178 1978-01-17
GB7901543A GB2012270B (en) 1978-01-17 1979-01-16 Crystallisation process

Publications (2)

Publication Number Publication Date
GB2012270A true GB2012270A (en) 1979-07-25
GB2012270B GB2012270B (en) 1982-08-18

Family

ID=26237051

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7901543A Expired GB2012270B (en) 1978-01-17 1979-01-16 Crystallisation process

Country Status (1)

Country Link
GB (1) GB2012270B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549836A1 (en) * 1983-07-29 1985-02-01 Glaxo Group Ltd PROCESS FOR PREPARING SODIUM SALT OF CEFUROXIME
US20180111949A1 (en) * 2016-10-22 2018-04-26 Hainan Lingkang Pharmaceutical Co., Ltd Novel industrial crystallization method of cefuroxime sodium and preparation thereof
CN112535666A (en) * 2020-12-15 2021-03-23 华北制药河北华民药业有限责任公司 Preparation method of high-stability cefuroxime sodium powder injection preparation for injection

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549836A1 (en) * 1983-07-29 1985-02-01 Glaxo Group Ltd PROCESS FOR PREPARING SODIUM SALT OF CEFUROXIME
US20180111949A1 (en) * 2016-10-22 2018-04-26 Hainan Lingkang Pharmaceutical Co., Ltd Novel industrial crystallization method of cefuroxime sodium and preparation thereof
CN112535666A (en) * 2020-12-15 2021-03-23 华北制药河北华民药业有限责任公司 Preparation method of high-stability cefuroxime sodium powder injection preparation for injection

Also Published As

Publication number Publication date
GB2012270B (en) 1982-08-18

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 19990115