GB201212502D0 - Improvements in or relating to allium extracts - Google Patents
Improvements in or relating to allium extractsInfo
- Publication number
- GB201212502D0 GB201212502D0 GBGB1212502.7A GB201212502A GB201212502D0 GB 201212502 D0 GB201212502 D0 GB 201212502D0 GB 201212502 A GB201212502 A GB 201212502A GB 201212502 D0 GB201212502 D0 GB 201212502D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- thiosulfinate
- allyl
- methiin
- alliin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000234282 Allium Species 0.000 title abstract 4
- 239000000284 extract Substances 0.000 title abstract 3
- ZIMQNNOENLFVMT-UHFFFAOYSA-N S-Methyl 2-propene-1-sulfinothioate Chemical compound CSS(=O)CC=C ZIMQNNOENLFVMT-UHFFFAOYSA-N 0.000 abstract 6
- ZZLHPCSGGOGHFW-KTCWOMIQSA-N (2r)-2-azaniumyl-3-[(s)-methylsulfinyl]propanoate Chemical compound C[S@](=O)C[C@H](N)C(O)=O ZZLHPCSGGOGHFW-KTCWOMIQSA-N 0.000 abstract 5
- ZZLHPCSGGOGHFW-UHFFFAOYSA-N S-methyl-L-cysteine sulphoxide Natural products CS(=O)CC(N)C(O)=O ZZLHPCSGGOGHFW-UHFFFAOYSA-N 0.000 abstract 5
- -1 thiosulfinate compounds Chemical class 0.000 abstract 5
- XUHLIQGRKRUKPH-GCXOYZPQSA-N Alliin Natural products N[C@H](C[S@@](=O)CC=C)C(O)=O XUHLIQGRKRUKPH-GCXOYZPQSA-N 0.000 abstract 4
- XUHLIQGRKRUKPH-UHFFFAOYSA-N S-allyl-L-cysteine sulfoxide Natural products OC(=O)C(N)CS(=O)CC=C XUHLIQGRKRUKPH-UHFFFAOYSA-N 0.000 abstract 4
- XUHLIQGRKRUKPH-DYEAUMGKSA-N alliin Chemical compound OC(=O)[C@@H](N)C[S@@](=O)CC=C XUHLIQGRKRUKPH-DYEAUMGKSA-N 0.000 abstract 4
- 235000015295 alliin Nutrition 0.000 abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 238000003786 synthesis reaction Methods 0.000 abstract 4
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 abstract 3
- BBZQGJLFMJHRSD-UHFFFAOYSA-N S-2-Propenyl methanesulfinothioate Chemical compound CS(=O)SCC=C BBZQGJLFMJHRSD-UHFFFAOYSA-N 0.000 abstract 3
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 abstract 3
- 235000010081 allicin Nutrition 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940029982 garlic powder Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
- A23L27/11—Natural spices, flavouring agents or condiments; Extracts thereof obtained by solvent extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/105—Persulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to improvements in or relating to Allium extracts. In particular, it relates to improvements in or relating to extending the therapeutic half- life or duration of Allium extracts. The invention also relates to the synthesis of certain thiosulfinate compounds, especially to the synthesis of methyl allyl thiosulfinate and allyl methyl thiosulfinate, in particular from either methiin or alliin alone or a mixture of both. The invention further relates to the synthesis of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allicin, and methyl methyl thiosulfinate in a mixture with varying molar or mass ratios depending on the reaction conditions, in particular from either methiin or alliin alone or a mixture of both. A high yielding, optimized synthesis of allicin starts from alliin, whereas methyl methyl thiosulfinate is advantageously obtained from methiin. Also provided is a kit comprising methiin in a first container and/or alliin in a second container and an allinase source, in particular garlic powder in a third container. Finally, the invention provides a method of preparing a mixture of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allyl allyl thiosulfinate (allicin) and methyl methyl thiosulfinate from methiin and pieces of an Allium species.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1212502.7A GB2505163A (en) | 2012-07-13 | 2012-07-13 | Allium extracts |
| PCT/GB2013/051892 WO2014009759A2 (en) | 2012-07-13 | 2013-07-15 | Improvements in or relating to allium extracts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1212502.7A GB2505163A (en) | 2012-07-13 | 2012-07-13 | Allium extracts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB201212502D0 true GB201212502D0 (en) | 2012-08-29 |
| GB2505163A GB2505163A (en) | 2014-02-26 |
Family
ID=46799584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1212502.7A Withdrawn GB2505163A (en) | 2012-07-13 | 2012-07-13 | Allium extracts |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2505163A (en) |
| WO (1) | WO2014009759A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104140384B (en) * | 2014-07-15 | 2016-07-20 | 江南大学 | The method of alkylthio/alkenyl cysteine sulfoxide is prepared in a kind of fractional crystallization |
| CN108562683B (en) * | 2018-04-18 | 2020-06-09 | 贵州景诚制药有限公司 | Quality detection method for Chinese chive root medicine |
| IT202000007234A1 (en) | 2020-04-06 | 2021-10-06 | Isagro Spa | Compounds with fungicidal activity, relative agronomic compositions and use for the control of phytopathogenic fungi |
| CN112362781A (en) * | 2020-11-09 | 2021-02-12 | 河北诚信集团有限公司 | Method for measuring content of sodium methanesulfinate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT397464B (en) * | 1992-10-07 | 1994-04-25 | Koch Heinrich P Dr | METHOD FOR OBTAINING A THERAPEUTIC PLANT EXTRACT |
| CA2833703A1 (en) * | 2004-05-05 | 2005-11-17 | Voloagri Group, Inc. | Green garlic and methods of production |
| GB0903869D0 (en) * | 2009-03-05 | 2009-04-22 | Neem Biotech Ltd | Process for the preparation of ajoene |
| CN101928735A (en) * | 2009-05-05 | 2010-12-29 | 广州军区广州总医院 | The preparation technology of ajoene (ajoene) |
| WO2011044113A1 (en) * | 2009-10-07 | 2011-04-14 | Wisconsin Alumni Research Foundation | Process of preparing conjugates of allium organosulfur compounds with amino acids, peptides, and proteins |
-
2012
- 2012-07-13 GB GB1212502.7A patent/GB2505163A/en not_active Withdrawn
-
2013
- 2013-07-15 WO PCT/GB2013/051892 patent/WO2014009759A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014009759A3 (en) | 2014-03-13 |
| WO2014009759A2 (en) | 2014-01-16 |
| GB2505163A (en) | 2014-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |