GB201212502D0 - Improvements in or relating to allium extracts - Google Patents

Improvements in or relating to allium extracts

Info

Publication number
GB201212502D0
GB201212502D0 GBGB1212502.7A GB201212502A GB201212502D0 GB 201212502 D0 GB201212502 D0 GB 201212502D0 GB 201212502 A GB201212502 A GB 201212502A GB 201212502 D0 GB201212502 D0 GB 201212502D0
Authority
GB
United Kingdom
Prior art keywords
methyl
thiosulfinate
allyl
methiin
alliin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB1212502.7A
Other versions
GB2505163A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LEPTREX Ltd
Original Assignee
LEPTREX Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEPTREX Ltd filed Critical LEPTREX Ltd
Priority to GB1212502.7A priority Critical patent/GB2505163A/en
Publication of GB201212502D0 publication Critical patent/GB201212502D0/en
Publication of GB2505163A publication Critical patent/GB2505163A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/10Natural spices, flavouring agents or condiments; Extracts thereof
    • A23L27/11Natural spices, flavouring agents or condiments; Extracts thereof obtained by solvent extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105Persulfides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

Abstract

The present invention relates to improvements in or relating to Allium extracts. In particular, it relates to improvements in or relating to extending the therapeutic half- life or duration of Allium extracts. The invention also relates to the synthesis of certain thiosulfinate compounds, especially to the synthesis of methyl allyl thiosulfinate and allyl methyl thiosulfinate, in particular from either methiin or alliin alone or a mixture of both. The invention further relates to the synthesis of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allicin, and methyl methyl thiosulfinate in a mixture with varying molar or mass ratios depending on the reaction conditions, in particular from either methiin or alliin alone or a mixture of both. A high yielding, optimized synthesis of allicin starts from alliin, whereas methyl methyl thiosulfinate is advantageously obtained from methiin. Also provided is a kit comprising methiin in a first container and/or alliin in a second container and an allinase source, in particular garlic powder in a third container. Finally, the invention provides a method of preparing a mixture of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allyl allyl thiosulfinate (allicin) and methyl methyl thiosulfinate from methiin and pieces of an Allium species.
GB1212502.7A 2012-07-13 2012-07-13 Allium extracts Pending GB2505163A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1212502.7A GB2505163A (en) 2012-07-13 2012-07-13 Allium extracts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1212502.7A GB2505163A (en) 2012-07-13 2012-07-13 Allium extracts
PCT/GB2013/051892 WO2014009759A2 (en) 2012-07-13 2013-07-15 Improvements in or relating to allium extracts

Publications (2)

Publication Number Publication Date
GB201212502D0 true GB201212502D0 (en) 2012-08-29
GB2505163A GB2505163A (en) 2014-02-26

Family

ID=46799584

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1212502.7A Pending GB2505163A (en) 2012-07-13 2012-07-13 Allium extracts

Country Status (2)

Country Link
GB (1) GB2505163A (en)
WO (1) WO2014009759A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104140384B (en) * 2014-07-15 2016-07-20 江南大学 The method of alkylthio/alkenyl cysteine sulfoxide is prepared in a kind of fractional crystallization
CN108562683B (en) * 2018-04-18 2020-06-09 贵州景诚制药有限公司 Quality detection method for Chinese chive root medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT397464B (en) * 1992-10-07 1994-04-25 Koch Heinrich P Dr Method for obtaining a therapeutic plant extract
US7937889B2 (en) * 2004-05-05 2011-05-10 Ophios, Llc Green garlic and methods of production
GB0903869D0 (en) * 2009-03-05 2009-04-22 Neem Biotech Ltd Process for the preparation of ajoene
CN101928735A (en) * 2009-05-05 2010-12-29 广州军区广州总医院 Preparation process of ajoene
WO2011044113A1 (en) * 2009-10-07 2011-04-14 Wisconsin Alumni Research Foundation Process of preparing conjugates of allium organosulfur compounds with amino acids, peptides, and proteins

Also Published As

Publication number Publication date
WO2014009759A3 (en) 2014-03-13
WO2014009759A2 (en) 2014-01-16
GB2505163A (en) 2014-02-26

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