GB2005246A - beta -Lactam compounds and processes for their preparation - Google Patents

beta -Lactam compounds and processes for their preparation

Info

Publication number
GB2005246A
GB2005246A GB7829593A GB7829593A GB2005246A GB 2005246 A GB2005246 A GB 2005246A GB 7829593 A GB7829593 A GB 7829593A GB 7829593 A GB7829593 A GB 7829593A GB 2005246 A GB2005246 A GB 2005246A
Authority
GB
United Kingdom
Prior art keywords
preparation
processes
compounds
beta
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7829593A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB7829593A priority Critical patent/GB2005246A/en
Publication of GB2005246A publication Critical patent/GB2005246A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Abstract

Compounds of the general formula <IMAGE> (wherein R<1> represents an alkyl group containing from 1 to 8 carbon atoms, optionally substituted by a hydroxy, etherified hydroxy or acylated hydroxy group; R<2a> represents a hydrogen atom or a carboxyl esterifying group; and B represents a sulphur atom or a group <IMAGE> and salts thereof and processes for their preparation. The compounds of formula (I) are useful as antibiotics or as intermediates for the preparation or purification of antibiotics. Intermediates of use in the preparation of compounds of formula (I) are also described.
GB7829593A 1977-07-13 1978-07-12 beta -Lactam compounds and processes for their preparation Withdrawn GB2005246A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7829593A GB2005246A (en) 1977-07-13 1978-07-12 beta -Lactam compounds and processes for their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2948777 1977-07-13
GB7829593A GB2005246A (en) 1977-07-13 1978-07-12 beta -Lactam compounds and processes for their preparation

Publications (1)

Publication Number Publication Date
GB2005246A true GB2005246A (en) 1979-04-19

Family

ID=26259940

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7829593A Withdrawn GB2005246A (en) 1977-07-13 1978-07-12 beta -Lactam compounds and processes for their preparation

Country Status (1)

Country Link
GB (1) GB2005246A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4282236A (en) 1979-11-07 1981-08-04 Beecham Group Limited β-Lactam antibacterial agents, their use in pharmaceutical compositions, and intermediates
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4515717A (en) * 1977-05-09 1985-05-07 Ciba Geigy Corporation Thia-aza compounds with a β-lactam ring
EP1686131A3 (en) * 2005-01-28 2006-08-16 Helm AG Process for preparation of penam derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515717A (en) * 1977-05-09 1985-05-07 Ciba Geigy Corporation Thia-aza compounds with a β-lactam ring
US4518533A (en) * 1977-05-09 1985-05-21 Ciba Geigy Corporation Azetidinone-4-disulfides as intermediates for thia-aza compounds with a beta-lactam ring
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4282236A (en) 1979-11-07 1981-08-04 Beecham Group Limited β-Lactam antibacterial agents, their use in pharmaceutical compositions, and intermediates
EP1686131A3 (en) * 2005-01-28 2006-08-16 Helm AG Process for preparation of penam derivatives

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)