GB1569660A - Occlusion of body channels - Google Patents

Occlusion of body channels Download PDF

Info

Publication number
GB1569660A
GB1569660A GB32015/77A GB3201577A GB1569660A GB 1569660 A GB1569660 A GB 1569660A GB 32015/77 A GB32015/77 A GB 32015/77A GB 3201577 A GB3201577 A GB 3201577A GB 1569660 A GB1569660 A GB 1569660A
Authority
GB
United Kingdom
Prior art keywords
body
channel
device according
material
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32015/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medline AB
Original Assignee
Medline AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SE7608618A priority Critical patent/SE7608618L/en
Application filed by Medline AB filed Critical Medline AB
Publication of GB1569660A publication Critical patent/GB1569660A/en
Application status is Expired legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/20Vas deferens occluders; Fallopian occluders
    • A61F6/22Vas deferens occluders; Fallopian occluders implantable in tubes
    • A61F6/225Vas deferens occluders; Fallopian occluders implantable in tubes transcervical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/20Vas deferens occluders; Fallopian occluders
    • A61F6/22Vas deferens occluders; Fallopian occluders implantable in tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers

Description

(54) OCCLUSION OF BODY CHANNELS (71) We, MEDLINE AB, a Swedish company, of Wallingatan 37, S-111 24 Stockholm, Sweden, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: The present invention relates to a device for temporary or permanent occlusion of channels or hollow spaces in human or animal bodies, particularly oviducts and spermatic ducts.

Human and animal bodies contain a vast number of channels, through which fluid and/or other substances or objects can pass or be transported. In certain cases, it is desirable to disrupt such a passage. For contraceptice purposes the spermatic ducts and the oviducts (fallopian tubes) could thus be occluded, whereby the passage of ova and sperms is prevented. In certain vascular diseases, for instance, it may be desired to stop the flow of blood through certain blood vessels. This is possible both on the arterial and vein side of the circulation. The methods hitherto used for this purpose have had disadvantages such as, for instance, that the passage through the channel has been difficult to occlude completely and/or to reopen, when desired. The means used for this purpose have brought problems of fitting; in the case of contraceptive devices such as described in the British Patent Specification No. 1 460077 there have been problems in providing an occlusion of the correct size.

It has now be found that these disadvantages can be eliminated by using a body consisting of a hydrogel, which, when brought into contact with a body fluid, swells at least 20%. Apart from this swelling, the body is to be essentially inert to the body fluids and to other surrounding tissues. This swelling of the body in contact with body fluid is preferably at least 40%, e.g. at least 80%. It could be varied between 20 and 300%. The channels in human being and animals, which can be occluded by this device are, for example, blood vessels, urethers, spermatic ducts and oviducts, The geometric form of the body is - not critical and it can be essentially cylindrical, spherical or egg-shaped. However, it has preferably a circular cross-section in the section corresponding to that of the channel to be occluded. This cross-section of the body is preferably so much smaller than the cross-section of the channel that the body can conveniently be introduced along the channel.

The device according to the invention is particularly suited for use as a contraceptive device. In this use the body is interted into the spermatic ducts or the oviducts. The body is in this case preferably attached to a thread in such a way that it can be withdrawn, normally without a surgical incision.

This thread can be made of an X-ray opaque material enabling localization of the position of the body.

The body itself can also possibly contain substances providing X-ray contrast.

When in contact with the body fluid the material of the body swells at least 20toss preferably at least 40%, e.g. at least 80%, and may even swell as much as 300%. In other respects, the material should be essentially inert and harmless to the body fluid and surrounding tissues and should not be absorbed by the human body. Suitable hydrogels for this purpose are polymers and copolymers of acrylic type, as e.g. crosslinked polyacrylamide and polymers and copolymers of methacrylic esters having at least one hydroxy radical in the side chain.

A preferred monomer is 2-hydroxy-ethyl methacrylate wherein the ester moiety can, for instance, derive from ethylene glycol or triethylene glycol. 2,3 - dihydroxypropyl methacrylate is also useful, for instance.

The body should be essentially elastic and plastic only to a very small extent. In unswollen (non-hydrated) state it may be stiff and/or hard (rigid), but should preferably soften in swelling. The body can con tain reinforcing material, e.g. armouring material, and also material making it more X-ray opaque. e.g. salts of barium or bismuth.

In use, the body is introduced into a channel in the unswollen state and will thereafter swell, when in contact with the body fluid, so that the body, which can pass through the channel when inserted, will swell and effectively contact the walls of the channel. Through the pressure then exerted by the walls on the body the elastic body will be slightly compressed simultaneously with a possible expansion of the elastic walls of the channel. In this way the body will fill the whole cross-section of the channel and prevent anything from passing through the channel simultaneously with the body being anchored in position. After insertion into an oviduct, the passage of ova to the uterus and spermatozoa, respectively, upwards through the oviduct to the unfertilized ovum will be prevented. After occlusion of a spermatic duct the outward passage of the spermatozoa will be prevented and a good contraceptive action is achieved. If desired, the inserted bodies can be withdrawn by operation or, as is the case when inserted in an oviduct, by extraction through the uterus in the case where the body is provided with an attached thread by which said extraction can be performed.

WHAT WE CLAIM IS: 1. A device for at least temporarily occluding channels or hollow spaces in human beings and animals, said device comprising a body adapted to be inserted into said channel or hollow space and made of a hydrogel which swells at least 20% when in contact with body fluid, and which is otherwise essentially inert to body fluid and surrounding tissues.

2. A device according to claim 1, wherein the material swells at least 40% and preferably at least 80% when in contact with body fluid.

3. A device according to claim 1 or claim 2, wherein the hydrogel is of acrylic type.

4. A device according to claim 3, wherein said hydrogel is a polymer or copolymer of methacrylic esters having at least one hydroxy radical in the side chain.

5. A device according to claim 4, wherein the ester moiety of the methacrylic ester is derived from a polyhydric alcohol.

6. A device according to any one of claims 1 to 5, wherein said body contains an X-ray opaque material.

7. A device according to any one of claims 1 to 6, wherein an indicator thread is built in or attached to the body, said indicator thread being optionally X-ray opaque.

**WARNING** end of DESC field may overlap start of CLMS **.

Claims (7)

**WARNING** start of CLMS field may overlap end of DESC **. tain reinforcing material, e.g. armouring material, and also material making it more X-ray opaque. e.g. salts of barium or bismuth. In use, the body is introduced into a channel in the unswollen state and will thereafter swell, when in contact with the body fluid, so that the body, which can pass through the channel when inserted, will swell and effectively contact the walls of the channel. Through the pressure then exerted by the walls on the body the elastic body will be slightly compressed simultaneously with a possible expansion of the elastic walls of the channel. In this way the body will fill the whole cross-section of the channel and prevent anything from passing through the channel simultaneously with the body being anchored in position. After insertion into an oviduct, the passage of ova to the uterus and spermatozoa, respectively, upwards through the oviduct to the unfertilized ovum will be prevented. After occlusion of a spermatic duct the outward passage of the spermatozoa will be prevented and a good contraceptive action is achieved. If desired, the inserted bodies can be withdrawn by operation or, as is the case when inserted in an oviduct, by extraction through the uterus in the case where the body is provided with an attached thread by which said extraction can be performed. WHAT WE CLAIM IS:
1. A device for at least temporarily occluding channels or hollow spaces in human beings and animals, said device comprising a body adapted to be inserted into said channel or hollow space and made of a hydrogel which swells at least 20% when in contact with body fluid, and which is otherwise essentially inert to body fluid and surrounding tissues.
2. A device according to claim 1, wherein the material swells at least 40% and preferably at least 80% when in contact with body fluid.
3. A device according to claim 1 or claim 2, wherein the hydrogel is of acrylic type.
4. A device according to claim 3, wherein said hydrogel is a polymer or copolymer of methacrylic esters having at least one hydroxy radical in the side chain.
5. A device according to claim 4, wherein the ester moiety of the methacrylic ester is derived from a polyhydric alcohol.
6. A device according to any one of claims 1 to 5, wherein said body contains an X-ray opaque material.
7. A device according to any one of claims 1 to 6, wherein an indicator thread is built in or attached to the body, said indicator thread being optionally X-ray opaque.
GB32015/77A 1976-07-30 1977-07-29 Occlusion of body channels Expired GB1569660A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE7608618A SE7608618L (en) 1976-07-30 1976-07-30 Again seen Charging of channels

Publications (1)

Publication Number Publication Date
GB1569660A true GB1569660A (en) 1980-06-18

Family

ID=20328570

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32015/77A Expired GB1569660A (en) 1976-07-30 1977-07-29 Occlusion of body channels

Country Status (3)

Country Link
GB (1) GB1569660A (en)
IN (1) IN148540B (en)
SE (1) SE7608618L (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4365621A (en) * 1979-05-04 1982-12-28 Ab Medline Device for members for closing body passages
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
US5478352A (en) * 1990-10-01 1995-12-26 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5540715A (en) * 1992-07-16 1996-07-30 Sherwood Medical Company Device for sealing hemostatic incisions
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5868778A (en) 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
US5957952A (en) * 1993-05-25 1999-09-28 Vascular Solutions, Inc. Vascular sealing device
US6017359A (en) * 1993-05-25 2000-01-25 Vascular Solutions, Inc. Vascular sealing apparatus
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US6071301A (en) * 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
WO2000054746A1 (en) * 1999-03-17 2000-09-21 Sujoy Kumar Guha An improved reversible contraceptive for male and female
US6183497B1 (en) 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US6315753B1 (en) 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6447534B2 (en) 1998-05-01 2002-09-10 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US6540735B1 (en) 2000-05-12 2003-04-01 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6544236B1 (en) 1999-02-10 2003-04-08 Sub-Q, Incorporated Device, system and method for improving delivery of hemostatic material
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US6733515B1 (en) 1997-03-12 2004-05-11 Neomend, Inc. Universal introducer
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US7695492B1 (en) 1999-09-23 2010-04-13 Boston Scientific Scimed, Inc. Enhanced bleed back system
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
US7955353B1 (en) 2002-11-04 2011-06-07 Sub-Q, Inc. Dissolvable closure device
US8050741B2 (en) 1998-05-01 2011-11-01 Boston Scientific Scimed, Inc. Device and method for facilitating hemostasis of a biopsy tract
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US8221452B2 (en) 1997-03-12 2012-07-17 Neomend, Inc. Systems and methods for sealing a vascular puncture
US8317821B1 (en) 2002-11-04 2012-11-27 Boston Scientific Scimed, Inc. Release mechanism

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4365621A (en) * 1979-05-04 1982-12-28 Ab Medline Device for members for closing body passages
US5478352A (en) * 1990-10-01 1995-12-26 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5591205A (en) * 1990-10-01 1997-01-07 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5601602A (en) * 1990-10-01 1997-02-11 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
US5630833A (en) * 1992-07-16 1997-05-20 Sherwood Medical Company Device for sealing hemostatic incisions
US5540715A (en) * 1992-07-16 1996-07-30 Sherwood Medical Company Device for sealing hemostatic incisions
US6017359A (en) * 1993-05-25 2000-01-25 Vascular Solutions, Inc. Vascular sealing apparatus
US6296658B1 (en) 1993-05-25 2001-10-02 Vascular Solutions, Inc. Vascular sealing apparatus
US5957952A (en) * 1993-05-25 1999-09-28 Vascular Solutions, Inc. Vascular sealing device
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5868778A (en) 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US6733515B1 (en) 1997-03-12 2004-05-11 Neomend, Inc. Universal introducer
US6562059B2 (en) 1997-03-12 2003-05-13 Neomend, Inc. Vascular sealing device with microwave antenna
US8221452B2 (en) 1997-03-12 2012-07-17 Neomend, Inc. Systems and methods for sealing a vascular puncture
US7081125B2 (en) 1997-03-12 2006-07-25 Neomend, Inc. Universal introducer
US6315753B1 (en) 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6440151B1 (en) 1998-05-01 2002-08-27 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US6183497B1 (en) 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6447534B2 (en) 1998-05-01 2002-09-10 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US8050741B2 (en) 1998-05-01 2011-11-01 Boston Scientific Scimed, Inc. Device and method for facilitating hemostasis of a biopsy tract
US7753872B2 (en) 1998-05-01 2010-07-13 Boston Scientific Scimed, Inc. Device, system and method for improving delivery of hemostatic material
US6086607A (en) * 1998-05-01 2000-07-11 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US6071301A (en) * 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
US6527734B2 (en) 1998-05-01 2003-03-04 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6440153B2 (en) 1998-05-01 2002-08-27 Sub-Q, Inc. Device and method for facilitating hemostasis of a biopsy tract
US6544236B1 (en) 1999-02-10 2003-04-08 Sub-Q, Incorporated Device, system and method for improving delivery of hemostatic material
WO2000054746A1 (en) * 1999-03-17 2000-09-21 Sujoy Kumar Guha An improved reversible contraceptive for male and female
US7695492B1 (en) 1999-09-23 2010-04-13 Boston Scientific Scimed, Inc. Enhanced bleed back system
US6540735B1 (en) 2000-05-12 2003-04-01 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US8524270B2 (en) 2001-03-12 2013-09-03 Boston Scientific Scimed, Inc. Cross-linked gelatin composition coated with a wetting agent
US8821918B2 (en) 2001-03-12 2014-09-02 Boston Scientific Scimed Inc. Cross-linked gelatin composition comprising a wetting agent
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US8317821B1 (en) 2002-11-04 2012-11-27 Boston Scientific Scimed, Inc. Release mechanism
US7955353B1 (en) 2002-11-04 2011-06-07 Sub-Q, Inc. Dissolvable closure device
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop

Also Published As

Publication number Publication date
SE7608618L (en) 1978-02-01
IN148540B (en) 1981-03-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee