GB1525372A - 4-deacetoxyvincristine - Google Patents
4-deacetoxyvincristineInfo
- Publication number
- GB1525372A GB1525372A GB7677/77A GB767777A GB1525372A GB 1525372 A GB1525372 A GB 1525372A GB 7677/77 A GB7677/77 A GB 7677/77A GB 767777 A GB767777 A GB 767777A GB 1525372 A GB1525372 A GB 1525372A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- deacetoxyvincristine
- acid addition
- addition salts
- deacetoxyvinblastine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000022244 formylation Effects 0.000 abstract 1
- 238000006170 formylation reaction Methods 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
- 229960004528 vincristine Drugs 0.000 abstract 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU76RI00000586A HU172183B (hu) | 1976-02-24 | 1976-02-24 | Spsosob poluchenija 4-dezacetoksi-vinkhristina i kislotodobavochnykh solejj |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1525372A true GB1525372A (en) | 1978-09-20 |
Family
ID=11000995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7677/77A Expired GB1525372A (en) | 1976-02-24 | 1977-02-23 | 4-deacetoxyvincristine |
Country Status (15)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112521408A (zh) * | 2020-12-16 | 2021-03-19 | 广州白云山汉方现代药业有限公司 | 一种双吲哚类生物碱化合物及其制备方法与应用 |
| CN114933604A (zh) * | 2021-12-10 | 2022-08-23 | 广州白云山汉方现代药业有限公司 | 一种长春新碱类手性化合物杂质及其制备方法与应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5891011A (ja) * | 1981-11-25 | 1983-05-30 | Toshiba Ceramics Co Ltd | α相含有率の高い窒化珪素粉末の製造方法 |
-
1976
- 1976-02-24 HU HU76RI00000586A patent/HU172183B/hu unknown
-
1977
- 1977-02-08 SE SE7701377A patent/SE430694B/xx not_active IP Right Cessation
- 1977-02-09 AT AT84177A patent/AT353429B/de not_active IP Right Cessation
- 1977-02-10 AU AU22173/77A patent/AU506508B2/en not_active Expired
- 1977-02-10 CH CH162477A patent/CH627185A5/de not_active IP Right Cessation
- 1977-02-15 DE DE19772706366 patent/DE2706366A1/de not_active Withdrawn
- 1977-02-17 IL IL51486A patent/IL51486A/xx unknown
- 1977-02-22 FR FR7705059A patent/FR2342295A1/fr active Granted
- 1977-02-22 BE BE175146A patent/BE851697A/xx not_active IP Right Cessation
- 1977-02-22 SU SU772453504A patent/SU673174A3/ru active
- 1977-02-23 NL NL7701948A patent/NL7701948A/xx not_active Application Discontinuation
- 1977-02-23 CA CA272,431A patent/CA1094551A/en not_active Expired
- 1977-02-23 DK DK78777AA patent/DK142815B/da not_active IP Right Cessation
- 1977-02-23 GB GB7677/77A patent/GB1525372A/en not_active Expired
- 1977-02-23 JP JP1824577A patent/JPS52102300A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112521408A (zh) * | 2020-12-16 | 2021-03-19 | 广州白云山汉方现代药业有限公司 | 一种双吲哚类生物碱化合物及其制备方法与应用 |
| CN114933604A (zh) * | 2021-12-10 | 2022-08-23 | 广州白云山汉方现代药业有限公司 | 一种长春新碱类手性化合物杂质及其制备方法与应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL51486A (en) | 1979-10-31 |
| DE2706366A1 (de) | 1977-08-25 |
| SU673174A3 (ru) | 1979-07-05 |
| JPS52102300A (en) | 1977-08-27 |
| IL51486A0 (en) | 1977-04-29 |
| SE430694B (sv) | 1983-12-05 |
| AU506508B2 (en) | 1980-01-10 |
| HU172183B (hu) | 1978-06-28 |
| FR2342295A1 (fr) | 1977-09-23 |
| FR2342295B1 (enrdf_load_stackoverflow) | 1980-09-05 |
| CH627185A5 (en) | 1981-12-31 |
| DK142815C (enrdf_load_stackoverflow) | 1981-08-24 |
| DK78777A (enrdf_load_stackoverflow) | 1977-08-25 |
| DK142815B (da) | 1981-02-02 |
| CA1094551A (en) | 1981-01-27 |
| NL7701948A (nl) | 1977-08-26 |
| AT353429B (de) | 1979-11-12 |
| AU2217377A (en) | 1978-08-17 |
| ATA84177A (de) | 1979-04-15 |
| BE851697A (fr) | 1977-06-16 |
| SE7701377L (sv) | 1977-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |