GB1499485A - Thiocarbamide derivatives and process for their preparation - Google Patents
Thiocarbamide derivatives and process for their preparationInfo
- Publication number
- GB1499485A GB1499485A GB10200/76A GB1020076A GB1499485A GB 1499485 A GB1499485 A GB 1499485A GB 10200/76 A GB10200/76 A GB 10200/76A GB 1020076 A GB1020076 A GB 1020076A GB 1499485 A GB1499485 A GB 1499485A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- image
- preparation
- thiocarbamide derivatives
- thiocarbamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940042794 thiocarbamide derivative for treatment of tuberculosis Drugs 0.000 title abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 230000000894 saliuretic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU75GO1303A HU173459B (hu) | 1975-03-14 | 1975-03-14 | Sposob poluchenija novykh proizvodnykh tiomocheviny |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1499485A true GB1499485A (en) | 1978-02-01 |
Family
ID=10996785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10200/76A Expired GB1499485A (en) | 1975-03-14 | 1976-03-15 | Thiocarbamide derivatives and process for their preparation |
Country Status (18)
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313172B1 (en) | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| US6534542B2 (en) | 2001-02-27 | 2003-03-18 | Allergen Sales, Inc. | (2-hydroxy)ethyl-thioureas useful as modulators of α2B adrenergic receptors |
| WO2003035178A1 (en) * | 2001-10-19 | 2003-05-01 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| JP2003530429A (ja) * | 2000-04-13 | 2003-10-14 | アラーガン、インコーポレイテッド | αアドレナリン受容体活性を調節するための方法および組成物 |
| US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7276522B2 (en) | 2002-05-21 | 2007-10-02 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7323485B2 (en) | 2002-05-21 | 2008-01-29 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7358269B2 (en) | 2002-05-21 | 2008-04-15 | Allergan, Inc. | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one |
| US7390829B2 (en) | 2005-06-29 | 2008-06-24 | Allergan, Inc. | Alpha-2 adrenergic agonists |
| US7396849B2 (en) | 2004-09-24 | 2008-07-08 | Allergan, Inc. | 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as α2 adrenergic agonists |
| US7399868B2 (en) | 2004-09-24 | 2008-07-15 | Allergan, Inc. | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists |
| US7683089B1 (en) | 2004-09-24 | 2010-03-23 | Allergan, Inc | 4-(Phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
| US7795292B2 (en) | 2004-09-28 | 2010-09-14 | Allergan, Inc. | Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206082B (en) * | 1988-12-23 | 1992-08-28 | Sandoz Ag | Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB974545A (en) * | 1963-03-14 | 1964-11-04 | Baxter Laboratories Inc | Thioureas |
-
1975
- 1975-03-12 SU SU752333906A patent/SU795462A3/ru active
- 1975-03-14 HU HU75GO1303A patent/HU173459B/hu unknown
-
1976
- 1976-03-10 IL IL49194A patent/IL49194A/xx unknown
- 1976-03-11 CS CS761604A patent/CS188132B2/cs unknown
- 1976-03-12 CA CA247,778A patent/CA1069931A/en not_active Expired
- 1976-03-12 AT AT185776A patent/AT347476B/de not_active IP Right Cessation
- 1976-03-12 DD DD191816A patent/DD125615A5/xx unknown
- 1976-03-12 FR FR7607110A patent/FR2303532A1/fr active Granted
- 1976-03-12 BE BE165107A patent/BE839502A/xx unknown
- 1976-03-12 DK DK107876A patent/DK107876A/da not_active Application Discontinuation
- 1976-03-12 SE SE7603242A patent/SE7603242L/xx not_active Application Discontinuation
- 1976-03-12 CH CH307076A patent/CH619210A5/de not_active IP Right Cessation
- 1976-03-13 PL PL1976187917A patent/PL101310B1/pl unknown
- 1976-03-14 EG EG152/76A patent/EG12505A/xx active
- 1976-03-15 IN IN456/CAL/1976A patent/IN143559B/en unknown
- 1976-03-15 NL NL7602670A patent/NL7602670A/xx not_active Application Discontinuation
- 1976-03-15 DE DE19762610865 patent/DE2610865A1/de not_active Withdrawn
- 1976-03-15 GB GB10200/76A patent/GB1499485A/en not_active Expired
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313172B1 (en) | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| US7754768B2 (en) | 2000-04-13 | 2010-07-13 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| JP2003530430A (ja) * | 2000-04-13 | 2003-10-14 | アラーガン、インコーポレイテッド | αアドレナリン作動性受容体活性を調節するための方法および組成物 |
| JP2003530429A (ja) * | 2000-04-13 | 2003-10-14 | アラーガン、インコーポレイテッド | αアドレナリン受容体活性を調節するための方法および組成物 |
| AU2001253383B2 (en) * | 2000-04-13 | 2005-10-06 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| AU2001253384B2 (en) * | 2000-04-13 | 2006-02-02 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| US6534542B2 (en) | 2001-02-27 | 2003-03-18 | Allergen Sales, Inc. | (2-hydroxy)ethyl-thioureas useful as modulators of α2B adrenergic receptors |
| US7335803B2 (en) | 2001-10-19 | 2008-02-26 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| WO2003035178A1 (en) * | 2001-10-19 | 2003-05-01 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| US7276522B2 (en) | 2002-05-21 | 2007-10-02 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7323485B2 (en) | 2002-05-21 | 2008-01-29 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7960423B2 (en) | 2002-05-21 | 2011-06-14 | Allergan, Inc | Imidazole-2-thiones |
| US7345077B2 (en) | 2002-05-21 | 2008-03-18 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4- (substituted cycloalkylmethyl) imidazol-2-ones and 4- (substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7358269B2 (en) | 2002-05-21 | 2008-04-15 | Allergan, Inc. | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one |
| US8071635B2 (en) | 2002-05-21 | 2011-12-06 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazole-2-ones and related compounds |
| US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US8063086B2 (en) | 2002-05-21 | 2011-11-22 | Allergan, Inc. | Imidazole-2-thiones |
| US7419994B2 (en) | 2002-05-21 | 2008-09-02 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds |
| US7569584B2 (en) | 2002-05-21 | 2009-08-04 | Allergan, Inc. | 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2b agonist and methods of using the same |
| US8063087B2 (en) | 2002-05-21 | 2011-11-22 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazole-2-ones and, 4-(substituted cycloalkylmethyl) imidazole-2-ones and related compounds |
| US7396849B2 (en) | 2004-09-24 | 2008-07-08 | Allergan, Inc. | 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as α2 adrenergic agonists |
| US7838545B2 (en) | 2004-09-24 | 2010-11-23 | Allergan, Inc. | 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists |
| US7683089B1 (en) | 2004-09-24 | 2010-03-23 | Allergan, Inc | 4-(Phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
| US7399868B2 (en) | 2004-09-24 | 2008-07-15 | Allergan, Inc. | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists |
| US7795292B2 (en) | 2004-09-28 | 2010-09-14 | Allergan, Inc. | Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same |
| US7390829B2 (en) | 2005-06-29 | 2008-06-24 | Allergan, Inc. | Alpha-2 adrenergic agonists |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| US8735438B2 (en) | 2008-01-09 | 2014-05-27 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| IL49194A (en) | 1980-09-16 |
| SU795462A3 (ru) | 1981-01-07 |
| CH619210A5 (en) | 1980-09-15 |
| ATA185776A (de) | 1978-05-15 |
| FR2303532B1 (enrdf_load_stackoverflow) | 1978-12-15 |
| EG12505A (en) | 1980-07-31 |
| DE2610865A1 (de) | 1976-09-30 |
| BE839502A (fr) | 1976-07-01 |
| DK107876A (da) | 1976-09-15 |
| NL7602670A (nl) | 1976-09-16 |
| AT347476B (de) | 1978-12-27 |
| FR2303532A1 (fr) | 1976-10-08 |
| IN143559B (enrdf_load_stackoverflow) | 1977-12-24 |
| CS188132B2 (en) | 1979-02-28 |
| DD125615A5 (enrdf_load_stackoverflow) | 1977-05-04 |
| SE7603242L (sv) | 1976-10-15 |
| HU173459B (hu) | 1979-05-28 |
| IL49194A0 (en) | 1976-05-31 |
| PL101310B1 (pl) | 1978-12-30 |
| CA1069931A (en) | 1980-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |