GB1496418A - Benzomorphanes derivatives - Google Patents

Benzomorphanes derivatives

Info

Publication number
GB1496418A
GB1496418A GB9633/75A GB963375A GB1496418A GB 1496418 A GB1496418 A GB 1496418A GB 9633/75 A GB9633/75 A GB 9633/75A GB 963375 A GB963375 A GB 963375A GB 1496418 A GB1496418 A GB 1496418A
Authority
GB
United Kingdom
Prior art keywords
methyl
formula
action
denotes hydrogen
morphine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9633/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical CH Boehringer Sohn AG and Co KG
Publication of GB1496418A publication Critical patent/GB1496418A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
GB9633/75A 1974-03-09 1975-03-07 Benzomorphanes derivatives Expired GB1496418A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2411382A DE2411382C3 (de) 1974-03-09 1974-03-09 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung

Publications (1)

Publication Number Publication Date
GB1496418A true GB1496418A (en) 1977-12-30

Family

ID=5909593

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9633/75A Expired GB1496418A (en) 1974-03-09 1975-03-07 Benzomorphanes derivatives

Country Status (25)

Country Link
JP (1) JPS5827275B2 (zh)
AT (1) AT344332B (zh)
BE (1) BE826440A (zh)
BG (3) BG25087A3 (zh)
CA (1) CA1049511A (zh)
CH (8) CH612425A5 (zh)
CS (1) CS188221B2 (zh)
DD (1) DD119236A5 (zh)
DE (1) DE2411382C3 (zh)
DK (1) DK137188C (zh)
ES (6) ES440349A1 (zh)
FI (1) FI63571C (zh)
FR (1) FR2262984B1 (zh)
GB (1) GB1496418A (zh)
HU (1) HU177408B (zh)
IE (1) IE40945B1 (zh)
IL (1) IL46760A (zh)
NL (1) NL7502724A (zh)
NO (1) NO141800C (zh)
PH (1) PH14127A (zh)
PL (3) PL93699B1 (zh)
RO (2) RO69617A (zh)
SE (1) SE421919B (zh)
SU (3) SU577982A3 (zh)
ZA (1) ZA751394B (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU708076B2 (en) * 1995-03-10 1999-07-29 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7217736B2 (en) 2000-07-27 2007-05-15 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7247655B2 (en) 1995-03-10 2007-07-24 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
CL2008002199A1 (es) 2007-07-26 2009-10-23 Vitae Pharmaceuticals Inc Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras.
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8138178B2 (en) 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
UY33001A (es) 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU708076B2 (en) * 1995-03-10 1999-07-29 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7247655B2 (en) 1995-03-10 2007-07-24 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7287646B2 (en) 1995-03-10 2007-10-30 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7850008B2 (en) 1995-03-10 2010-12-14 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US8410172B2 (en) 1995-03-10 2013-04-02 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7217736B2 (en) 2000-07-27 2007-05-15 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7563819B1 (en) 2000-07-27 2009-07-21 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Also Published As

Publication number Publication date
PL93499B1 (zh) 1977-05-30
ES440348A1 (es) 1977-06-01
CS188221B2 (en) 1979-02-28
ES440345A1 (es) 1977-03-01
CA1049511A (en) 1979-02-27
NO141800C (no) 1980-06-04
ZA751394B (en) 1976-11-24
RO69617A (ro) 1980-08-15
SU588916A3 (ru) 1978-01-15
CH622016A5 (en) 1981-03-13
HU177408B (en) 1981-10-28
PL93700B1 (zh) 1977-06-30
CH622017A5 (en) 1981-03-13
ES440349A1 (es) 1977-03-01
CH622015A5 (en) 1981-03-13
RO70051A (ro) 1980-12-30
JPS50123675A (zh) 1975-09-29
CH620440A5 (en) 1980-11-28
DK137188B (da) 1978-01-30
AU7894275A (en) 1976-09-16
FI63571C (fi) 1983-07-11
DE2411382A1 (de) 1975-09-18
PH14127A (en) 1981-02-26
DK137188C (da) 1978-07-03
SE7502592L (zh) 1975-09-10
DE2411382B2 (de) 1979-01-18
JPS5827275B2 (ja) 1983-06-08
CH612425A5 (en) 1979-07-31
FI750652A (zh) 1975-09-10
ATA153875A (de) 1977-11-15
BG24813A4 (en) 1978-05-12
DK92975A (zh) 1975-09-10
PL93699B1 (zh) 1977-06-30
SU577982A3 (ru) 1977-10-25
IE40945B1 (en) 1979-09-12
IL46760A (en) 1978-12-17
FI63571B (fi) 1983-03-31
BG25087A3 (en) 1978-07-12
DD119236A5 (zh) 1976-04-12
NO141800B (no) 1980-02-04
BE826440A (fr) 1975-09-08
SU577983A3 (ru) 1977-10-25
FR2262984A1 (zh) 1975-10-03
IE40945L (en) 1975-09-09
ES440346A1 (es) 1977-03-01
ES440350A1 (es) 1977-03-16
NO750773L (zh) 1975-09-10
IL46760A0 (en) 1975-05-22
SE421919B (sv) 1982-02-08
ES440347A1 (es) 1977-06-01
AT344332B (de) 1978-07-10
CH620681A5 (en) 1980-12-15
CH622014A5 (en) 1981-03-13
CH620439A5 (en) 1980-11-28
NL7502724A (nl) 1975-09-11
DE2411382C3 (de) 1979-09-06
BG24814A4 (en) 1978-05-12
FR2262984B1 (zh) 1978-07-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee