GB1485659A - Disintegrating agent for tablets - Google Patents
Disintegrating agent for tabletsInfo
- Publication number
- GB1485659A GB1485659A GB4873375A GB4873375A GB1485659A GB 1485659 A GB1485659 A GB 1485659A GB 4873375 A GB4873375 A GB 4873375A GB 4873375 A GB4873375 A GB 4873375A GB 1485659 A GB1485659 A GB 1485659A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tablets
- tubules
- cellulose
- tablet
- ethyl cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Abstract
1485659 Disintegrating agent for tablets DOW CHEMICAL CO 27 Nov 1975 48733/75 Headings A5B and A5E A disintegrating agent for tablets (defined as being a compressed or moulded mass of solid material comprising an active ingredient) comprises a plurality of tubules having a length of 0.5 micron to 3 mm., a substantially uniform internal cross sectional area corresponding to an inside diameter of 5 to 1000 microns and a substantially uniform wall thickness corresponding to an outside diameter of 25 to 1100 microns. The tubules are incorporated into pharmaceutical or disinfectant tablets in an amount of 0.1 to 90% by weight of the tablet. They are preferably of a water swellable material e.g. ethyl cellulose, carboxymethyl cellulose, cellulose acetate, hydroxypropylmethyl cellulose, cellulose or gelatin, and have a bulk density of 0.1 to 0.6 gms/cc. They may be produced by sub-dividing hollow fibres, e.g. those commercially available for use in dialysis produced by extrusion, melt-spinning or coating a filamentous core and then dissolving the core. The tablets are prepared by mixing the material to be formed into tablets, if necessary after wet or dry granulation, with the tubules and then compressing the mixture into tablets using a pressure which does not permanently collapse the tubules. The tubules may be dyed prior to incorporation in the tablet to give a tablet having a coloured speckled appearance. If required, the tablets may be coated to control disingration time. In the Examples, pharmaceutical tablets containing aspirin, rifampicin, and quinidine sulphate are prepared. A disinfectant tablet for use in aqueous systems such as water closets, humidifier tanks and wading pools is prepared by granulating sodium bisulphite with ethyl cellulose and spray-coating the granulate with shellac, forming a second granulate of sodium iodide and ethyl cellulose, mixing both granulates with 2, 2-dibromo-3-nitrilopropionamide and tubules of hydroxypropyl ethyl cellulose and compressing into tablets. In use the nitrilopropionamide has an initial disinfecting action which is synergised by the sodium iodide; later slow release of sodium bisulphite then detoxifies the disinfectant.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/508,025 US3951821A (en) | 1972-07-14 | 1974-09-20 | Disintegrating agent for tablets |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1485659A true GB1485659A (en) | 1977-09-14 |
Family
ID=24021073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4873375A Expired GB1485659A (en) | 1974-09-20 | 1975-11-27 | Disintegrating agent for tablets |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE836041A (en) |
DE (1) | DE2552473A1 (en) |
FR (1) | FR2333495A1 (en) |
GB (1) | GB1485659A (en) |
NL (1) | NL7513790A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112250505A (en) * | 2020-10-30 | 2021-01-22 | 云南云天化红磷化工有限公司 | Disintegrating agent for instant granular ammonium phosphate and preparation method and application thereof |
-
1975
- 1975-11-22 DE DE19752552473 patent/DE2552473A1/en not_active Withdrawn
- 1975-11-26 NL NL7513790A patent/NL7513790A/en not_active Application Discontinuation
- 1975-11-27 BE BE162256A patent/BE836041A/en unknown
- 1975-11-27 GB GB4873375A patent/GB1485659A/en not_active Expired
- 1975-12-01 FR FR7536748A patent/FR2333495A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112250505A (en) * | 2020-10-30 | 2021-01-22 | 云南云天化红磷化工有限公司 | Disintegrating agent for instant granular ammonium phosphate and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
BE836041A (en) | 1976-05-28 |
FR2333495A1 (en) | 1977-07-01 |
NL7513790A (en) | 1977-05-31 |
DE2552473A1 (en) | 1977-05-26 |
FR2333495B1 (en) | 1978-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |