GB1478968A - Alkylated pregnanes - Google Patents
Alkylated pregnanesInfo
- Publication number
- GB1478968A GB1478968A GB33149/73A GB3314973A GB1478968A GB 1478968 A GB1478968 A GB 1478968A GB 33149/73 A GB33149/73 A GB 33149/73A GB 3314973 A GB3314973 A GB 3314973A GB 1478968 A GB1478968 A GB 1478968A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- dione
- hydroxy
- pregnen
- pregnadiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003128 pregnanes Chemical class 0.000 title 1
- 239000004593 Epoxy Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000003431 steroids Chemical class 0.000 abstract 3
- 229940126062 Compound A Drugs 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 150000002009 diols Chemical class 0.000 abstract 2
- GUHFLRTWNHWJBS-VLTGGNAYSA-N (8r,9s,10s,13s)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12-decahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1C1=CC=C(C(=O)C)[C@@]1(C)CC2 GUHFLRTWNHWJBS-VLTGGNAYSA-N 0.000 abstract 1
- NBLHTECOWAHOPA-LVUPHWHUSA-N (9r,10s,13s)-17-acetyl-10,13-dimethyl-1,2,4,5,6,9,11,12-octahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@@H](CC[C@@]3(C(C(=O)C)=CC=C33)C)C3=CCC21 NBLHTECOWAHOPA-LVUPHWHUSA-N 0.000 abstract 1
- OUNLEGKRZUPPOS-ONTSXIIYSA-N 1-[(8r,9s,10s,13s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12-decahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1C1=CC=C(C(=O)C)[C@@]1(C)CC2 OUNLEGKRZUPPOS-ONTSXIIYSA-N 0.000 abstract 1
- PQGMAKFMGGZKBA-SRJGTTDWSA-N 1-[(8r,9s,10s,13s,14s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC=C(C(=O)C)[C@@]1(C)CC2 PQGMAKFMGGZKBA-SRJGTTDWSA-N 0.000 abstract 1
- KBXXJWDSHUJCMA-UHFFFAOYSA-N 3-(oxan-3-yloxy)oxane Chemical compound C1CCOCC1OC1COCCC1 KBXXJWDSHUJCMA-UHFFFAOYSA-N 0.000 abstract 1
- PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- YLIAINUFORNGRF-PPFHTQHNSA-N C(C)(=O)O.CC(C1=CC=C2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)=O Chemical compound C(C)(=O)O.CC(C1=CC=C2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)=O YLIAINUFORNGRF-PPFHTQHNSA-N 0.000 abstract 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000950 dibromo group Chemical group Br* 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 101150086745 pre gene Proteins 0.000 abstract 1
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33149/73A GB1478968A (en) | 1973-07-11 | 1973-07-11 | Alkylated pregnanes |
| IE1428/74A IE39593B1 (en) | 1973-07-11 | 1974-07-05 | Novel alkylated pregnanes |
| ZA00744381A ZA744381B (en) | 1973-07-11 | 1974-07-08 | Novel alkylated pregnanes and process for obtaining same |
| FI742103A FI52100C (fi) | 1973-07-11 | 1974-07-09 | Menetelmä uudien pregnaanisarjaan kuuluvien, tulehduksenvastaisten 21- asemassa alkyloitujen steroidien valmistamiseksi. |
| AU71040/74A AU487996B2 (en) | 1974-07-09 | Novel alkylated pregnanes and process for obtaining same | |
| ES428132A ES428132A1 (es) | 1973-07-11 | 1974-07-10 | Procedimiento para la preparacion de nuevos esteroides al- cohilados de la serie del pregnano. |
| NL7409298A NL7409298A (nl) | 1973-07-11 | 1974-07-10 | Werkwijze voor het bereiden van nieuwe geal- kyleerde steroiden van de pregnaanreeks. |
| DE2433178A DE2433178A1 (de) | 1973-07-11 | 1974-07-10 | In 21-stellung alkylierte steroide der pregnanreihe |
| DK371174AA DK134700B (da) | 1973-07-11 | 1974-07-10 | Analogifremgangsmåde til fremstilling af 21-alkylerede 16alfa,17alfa-alkylidendioxy-pregn-4-en-3,20-dioner. |
| JP49079023A JPS5047968A (enrdf_load_stackoverflow) | 1973-07-11 | 1974-07-10 | |
| SE7409046A SE402920B (sv) | 1973-07-11 | 1974-07-10 | Forfarande for framstellning av nya 21-alkylerade 16alfa, 17alfa-alkylidendioxi-pregn-4-en-3,20-dioner |
| CA204,503A CA1050529A (en) | 1973-07-11 | 1974-07-10 | Alkylated pregnanes and process for obtaining same |
| FR7424189A FR2236508B1 (enrdf_load_stackoverflow) | 1973-07-11 | 1974-07-11 | |
| BE146467A BE817543A (nl) | 1973-07-11 | 1974-07-11 | Nieuwe gealkyleerde steroiden van de pregnaanreeks en werkwijze voor het bereiden hiervan |
| HU74AO00000386A HU171711B (hu) | 1973-07-11 | 1974-07-11 | Sposob poluchenija 16-al'fa,17-al'fa-alkilidendioksi-21-alkil-steroidov v rjade pregnanov |
| US05/663,893 US4031075A (en) | 1973-07-11 | 1976-03-04 | Alkylated pregnanes and process for obtaining same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33149/73A GB1478968A (en) | 1973-07-11 | 1973-07-11 | Alkylated pregnanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1478968A true GB1478968A (en) | 1977-07-06 |
Family
ID=10349189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33149/73A Expired GB1478968A (en) | 1973-07-11 | 1973-07-11 | Alkylated pregnanes |
Country Status (14)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260605A (en) * | 1979-01-24 | 1981-04-07 | Akzo N.V. | Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1134455B (it) * | 1980-11-26 | 1986-08-13 | Lepetit Spa | Procedimento per la preparazione di derivati 16alfa-idrossi-17alfa-aminopregnanici |
| AU7556291A (en) * | 1990-03-27 | 1991-10-21 | Schering Corporation | Process for 9alpha-hydroxy steroid dehydration |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3064017A (en) * | 1962-11-13 | Preparation viii | ||
| GB1416427A (en) * | 1972-01-12 | 1975-12-03 | Akzo Nv | Alkylated pregnanes and process for obtaining same |
-
1973
- 1973-07-11 GB GB33149/73A patent/GB1478968A/en not_active Expired
-
1974
- 1974-07-05 IE IE1428/74A patent/IE39593B1/xx unknown
- 1974-07-08 ZA ZA00744381A patent/ZA744381B/xx unknown
- 1974-07-09 FI FI742103A patent/FI52100C/fi active
- 1974-07-10 ES ES428132A patent/ES428132A1/es not_active Expired
- 1974-07-10 JP JP49079023A patent/JPS5047968A/ja active Pending
- 1974-07-10 DE DE2433178A patent/DE2433178A1/de active Pending
- 1974-07-10 NL NL7409298A patent/NL7409298A/xx not_active Application Discontinuation
- 1974-07-10 CA CA204,503A patent/CA1050529A/en not_active Expired
- 1974-07-10 SE SE7409046A patent/SE402920B/xx unknown
- 1974-07-10 DK DK371174AA patent/DK134700B/da unknown
- 1974-07-11 BE BE146467A patent/BE817543A/xx unknown
- 1974-07-11 HU HU74AO00000386A patent/HU171711B/hu unknown
- 1974-07-11 FR FR7424189A patent/FR2236508B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260605A (en) * | 1979-01-24 | 1981-04-07 | Akzo N.V. | Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same |
Also Published As
| Publication number | Publication date |
|---|---|
| DK134700C (enrdf_load_stackoverflow) | 1977-07-11 |
| ES428132A1 (es) | 1976-07-16 |
| SE7409046L (sv) | 1975-01-13 |
| IE39593B1 (en) | 1978-11-22 |
| FI52100C (fi) | 1977-06-10 |
| SE402920B (sv) | 1978-07-24 |
| CA1050529A (en) | 1979-03-13 |
| DE2433178A1 (de) | 1975-01-30 |
| JPS5047968A (enrdf_load_stackoverflow) | 1975-04-28 |
| FI210374A7 (enrdf_load_stackoverflow) | 1975-01-12 |
| DK134700B (da) | 1976-12-27 |
| ZA744381B (en) | 1975-07-30 |
| AU7104074A (en) | 1976-01-15 |
| NL7409298A (nl) | 1975-01-14 |
| BE817543A (nl) | 1975-01-13 |
| FR2236508B1 (enrdf_load_stackoverflow) | 1978-07-28 |
| FI52100B (enrdf_load_stackoverflow) | 1977-02-28 |
| IE39593L (en) | 1975-01-11 |
| HU171711B (hu) | 1978-03-28 |
| DK371174A (enrdf_load_stackoverflow) | 1975-03-17 |
| FR2236508A1 (enrdf_load_stackoverflow) | 1975-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |