GB1472870A - Process for preparing cephalosporins - Google Patents
Process for preparing cephalosporinsInfo
- Publication number
- GB1472870A GB1472870A GB2841076A GB2841076A GB1472870A GB 1472870 A GB1472870 A GB 1472870A GB 2841076 A GB2841076 A GB 2841076A GB 2841076 A GB2841076 A GB 2841076A GB 1472870 A GB1472870 A GB 1472870A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- base
- inorganic
- residue
- suitably
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 cyanomethyl Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 239000002585 base Substances 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 229910018072 Al 2 O 3 Inorganic materials 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
- 229910004298 SiO 2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005210 alkyl ammonium group Chemical group 0.000 abstract 1
- VPEWBHUCZWYJGM-UHFFFAOYSA-N amino-(2-azidoacetyl)oxycarbamic acid Chemical compound C(C(=O)ON(C(=O)O)N)N=[N+]=[N-] VPEWBHUCZWYJGM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910052809 inorganic oxide Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Document Processing Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23070/74A IT1043958B (it) | 1974-05-22 | 1974-05-22 | Procedimento per la preparazione di cefalosporine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1472870A true GB1472870A (en) | 1977-05-11 |
Family
ID=11203454
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2841076A Expired GB1472870A (en) | 1974-05-22 | 1975-05-20 | Process for preparing cephalosporins |
| GB2141975A Expired GB1472865A (en) | 1974-05-22 | 1975-05-20 | Process for preparing thiohydrozoazetidiones |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2141975A Expired GB1472865A (en) | 1974-05-22 | 1975-05-20 | Process for preparing thiohydrozoazetidiones |
Country Status (16)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1472866A (en) | 1974-06-12 | 1977-05-11 | Farmaceutici Italia | Cephalosporins and intermediates therefor |
| GB1576219A (en) | 1976-12-31 | 1980-10-01 | Connlab Holdings Ltd | Thiazoleneazetidinone derivatives |
| NL7806860A (nl) * | 1977-07-05 | 1979-01-09 | Farmaceutici Italia | Werkwijze voor het bereiden van met nocardicine verwan- te azetidinonen. |
| US4482491A (en) * | 1981-05-01 | 1984-11-13 | Otsuka Kagaku Yakuhin Kabushiki Kaisha | Thiazolinoazetidinone derivatives and process for the preparation of the same |
| EP0088488B1 (en) * | 1982-01-22 | 1986-10-01 | Beecham Group Plc | Antibacterial agents, their preparation and use |
-
1974
- 1974-05-22 IT IT23070/74A patent/IT1043958B/it active
-
1975
- 1975-05-16 AT AT376875A patent/AT340047B/de not_active IP Right Cessation
- 1975-05-16 NL NLAANVRAGE7505800,A patent/NL170286C/xx not_active IP Right Cessation
- 1975-05-17 DE DE19752522142 patent/DE2522142A1/de not_active Withdrawn
- 1975-05-20 CA CA227,388A patent/CA1055485A/en not_active Expired
- 1975-05-20 FR FR7515596A patent/FR2279753A1/fr active Granted
- 1975-05-20 SE SE7505751A patent/SE7505751L/xx unknown
- 1975-05-20 ZA ZA00753244A patent/ZA753244B/xx unknown
- 1975-05-20 DK DK220375A patent/DK220375A/da unknown
- 1975-05-20 HU HU75SO00001145A patent/HU171357B/hu unknown
- 1975-05-20 NO NO751781A patent/NO751781L/no unknown
- 1975-05-20 GB GB2841076A patent/GB1472870A/en not_active Expired
- 1975-05-20 JP JP50059355A patent/JPS50160291A/ja active Pending
- 1975-05-20 GB GB2141975A patent/GB1472865A/en not_active Expired
- 1975-05-21 BE BE156546A patent/BE829304A/xx not_active IP Right Cessation
- 1975-05-21 ES ES437842A patent/ES437842A1/es not_active Expired
- 1975-05-21 SU SU752133714A patent/SU727147A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA753244B (en) | 1976-05-26 |
| AU8131975A (en) | 1976-11-25 |
| HU171357B (hu) | 1977-12-28 |
| NL170286B (nl) | 1982-05-17 |
| IT1043958B (it) | 1980-02-29 |
| JPS50160291A (enrdf_load_stackoverflow) | 1975-12-25 |
| AT340047B (de) | 1977-11-25 |
| NL7505800A (nl) | 1975-11-25 |
| FR2279753A1 (fr) | 1976-02-20 |
| DK220375A (da) | 1975-11-23 |
| GB1472865A (en) | 1977-05-11 |
| DE2522142A1 (de) | 1975-12-11 |
| SE7505751L (sv) | 1975-11-24 |
| BE829304A (fr) | 1975-11-21 |
| NL170286C (nl) | 1982-10-18 |
| CA1055485A (en) | 1979-05-29 |
| FR2279753B1 (enrdf_load_stackoverflow) | 1979-03-16 |
| SU727147A3 (ru) | 1980-04-05 |
| NO751781L (enrdf_load_stackoverflow) | 1975-11-25 |
| ES437842A1 (es) | 1977-01-01 |
| ATA376875A (de) | 1977-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1294541A (en) | Cephalosporanic acid derivatives | |
| GB1472870A (en) | Process for preparing cephalosporins | |
| IE36084L (en) | 3-methylene cephalosporins | |
| ES412859A1 (es) | Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina. | |
| GR76356B (enrdf_load_stackoverflow) | ||
| GB1493676A (en) | Antibiotic method and pharmaceutical compositions | |
| ES393801A1 (es) | Un procedimiento para la preparacion de compuestos semisin-teticos utilizados en la produccion de cefalosporinas, peni-cilinas y compuestos antibioticos relacionados de beta-lac- tama. | |
| GB1472866A (en) | Cephalosporins and intermediates therefor | |
| JPS5535096A (en) | 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent | |
| GB1066347A (en) | New derivatives of 7-amino-cephalosporamic acid and process for their manufacture | |
| ES461688A1 (es) | Un procedimiento para la preparacion de nuevos compuestos decefalosporina. | |
| GB1265315A (enrdf_load_stackoverflow) | ||
| ES452779A1 (es) | Procedimiento para la obtencion de cefaloesporinas. | |
| GB982252A (en) | New cephalosporin compounds and method for preparing same | |
| IE33571L (en) | Preparation of cephalosporins | |
| GB1464330A (en) | Cephalosporin esters with antibacterial activity | |
| YU45815B (sh) | Postopek za pripravo novih dušikarilmetoksitiofenskih derivatov | |
| ES447615A1 (es) | Un procedimiento para obtener compuesto de cefalosporina. | |
| ES446132A1 (es) | Un procedimiento para la preparacion de nuevos derivados de acido 2-alquil (inferior)-2 o 3-cefem-4-carboxilico. | |
| ES444902A1 (es) | Procedimiento para preparar un acido 7-(acetamido &, l disustituido)-3-sustituido-3-ceben-4-carboxilico. | |
| GB1389540A (en) | Derivatives of alpha-aminocephalosporins | |
| GB992983A (en) | Cephalosporin compounds | |
| ES433302A1 (es) | Un procedimiento para obtener derivados de cefalosporina. | |
| GB1398564A (en) | 1-amino substituted-1-cycloalkane derivatives of 6-amino penicillanic acid | |
| JPS5476591A (en) | Novel method of preparing 7-substituted or unsubstituted amino-3-substituted thiomethylcephemcarboxylic acid derivative |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |