GB1434323A - N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation - Google Patents
N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparationInfo
- Publication number
- GB1434323A GB1434323A GB378474A GB378474A GB1434323A GB 1434323 A GB1434323 A GB 1434323A GB 378474 A GB378474 A GB 378474A GB 378474 A GB378474 A GB 378474A GB 1434323 A GB1434323 A GB 1434323A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- homopiperazine
- derivative
- chloro
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 150000004050 homopiperazines Chemical class 0.000 title abstract 4
- 150000004885 piperazines Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000000010 aprotic solvent Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 4-n-octyloxyphenyl group Chemical group 0.000 abstract 1
- 241000251556 Chordata Species 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2304155A DE2304155A1 (de) | 1973-01-29 | 1973-01-29 | N-acylierte substituierte piperazinbzw. homopiperazinderivate, sowie verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1434323A true GB1434323A (en) | 1976-05-05 |
Family
ID=5870202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB378474A Expired GB1434323A (en) | 1973-01-29 | 1974-01-28 | N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS505389A (enrdf_load_stackoverflow) |
| BE (1) | BE810293A (enrdf_load_stackoverflow) |
| DE (1) | DE2304155A1 (enrdf_load_stackoverflow) |
| ES (1) | ES422738A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2215236B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1434323A (enrdf_load_stackoverflow) |
| NL (1) | NL7401215A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585774A (en) * | 1981-05-08 | 1986-04-29 | Otsuka Pharmaceutical Co., Ltd. | Aniline derivatives and cardiotonic composition |
| US6534509B1 (en) * | 1997-06-12 | 2003-03-18 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| WO2011026241A1 (en) * | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Substituted heterocyclic derivatives for the treatment of pain and epilepsy |
| US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180574A (en) * | 1978-12-26 | 1979-12-25 | Abbott Laboratories | Certain ovicidal piperazines |
| JPS5879986A (ja) * | 1981-11-06 | 1983-05-13 | Otsuka Pharmaceut Co Ltd | アニリン誘導体 |
| WO2001062749A1 (en) * | 2000-02-22 | 2001-08-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| ATE449090T1 (de) * | 2001-07-02 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
| US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
| CA2564068A1 (en) * | 2004-04-15 | 2005-11-17 | Samaritan Pharmaceuticals, Inc. | Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of alzheimer's disease |
| JP2008007443A (ja) * | 2006-06-28 | 2008-01-17 | Shiseido Co Ltd | 桂皮酸誘導体、その紫外線吸収剤としての用途、及びこれを配合した紫外線吸収性組成物、皮膚外用剤。 |
| WO2009031202A1 (ja) * | 2007-09-04 | 2009-03-12 | Shiseido Company Ltd. | 桂皮酸誘導体及びその紫外線吸収剤としての利用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE774447A (fr) * | 1970-11-11 | 1972-02-14 | Biasedra Lab | Nouveaux derives de la salicylamide et leur application en therapeutique |
-
1973
- 1973-01-29 DE DE2304155A patent/DE2304155A1/de active Pending
-
1974
- 1974-01-28 GB GB378474A patent/GB1434323A/en not_active Expired
- 1974-01-29 FR FR7402849A patent/FR2215236B1/fr not_active Expired
- 1974-01-29 BE BE140287A patent/BE810293A/xx unknown
- 1974-01-29 ES ES422738A patent/ES422738A1/es not_active Expired
- 1974-01-29 NL NL7401215A patent/NL7401215A/xx unknown
- 1974-01-29 JP JP49012644A patent/JPS505389A/ja active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585774A (en) * | 1981-05-08 | 1986-04-29 | Otsuka Pharmaceutical Co., Ltd. | Aniline derivatives and cardiotonic composition |
| US6534509B1 (en) * | 1997-06-12 | 2003-03-18 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| US6972290B2 (en) | 1997-06-12 | 2005-12-06 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| US6977258B2 (en) | 1997-06-12 | 2005-12-20 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| US7268140B2 (en) | 1997-06-12 | 2007-09-11 | Schering Ag | Piperazine derivatives and their use as anti-inflammatory agents |
| WO2011026241A1 (en) * | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Substituted heterocyclic derivatives for the treatment of pain and epilepsy |
| CN102656151A (zh) * | 2009-09-04 | 2012-09-05 | 扎里卡斯药品有限公司 | 治疗疼痛和癫痫的取代的杂环衍生物 |
| US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215236B1 (enrdf_load_stackoverflow) | 1977-11-04 |
| BE810293A (fr) | 1974-05-16 |
| DE2304155A1 (de) | 1974-08-01 |
| FR2215236A1 (enrdf_load_stackoverflow) | 1974-08-23 |
| JPS505389A (enrdf_load_stackoverflow) | 1975-01-21 |
| NL7401215A (enrdf_load_stackoverflow) | 1974-07-31 |
| ES422738A1 (es) | 1976-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |