GB1413198A - - Google Patents
Info
- Publication number
- GB1413198A GB1413198A GB5932373A GB5932373A GB1413198A GB 1413198 A GB1413198 A GB 1413198A GB 5932373 A GB5932373 A GB 5932373A GB 5932373 A GB5932373 A GB 5932373A GB 1413198 A GB1413198 A GB 1413198A
- Authority
- GB
- United Kingdom
- Prior art keywords
- peptide
- deprotecting
- protected
- support
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- -1 N-protected phenylalanine Chemical class 0.000 abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 3
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- 101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 abstract 2
- 101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 102000058004 human PTH Human genes 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- 101001135732 Bos taurus Parathyroid hormone Proteins 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 102100036893 Parathyroid hormone Human genes 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31770272A | 1972-12-21 | 1972-12-21 | |
| US423303A US3886132A (en) | 1972-12-21 | 1973-12-10 | Human parathyroid hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1413198A true GB1413198A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-11-12 |
Family
ID=26981092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5932373A Expired GB1413198A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-12-21 | 1973-12-21 |
Country Status (4)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409141A (en) | 1980-12-29 | 1983-10-11 | Toyo Jozo Kabushiki Kaisha | Peptides for assaying human parathyroid hormone |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105602A (en) * | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4301045A (en) * | 1977-05-02 | 1981-11-17 | Armour Pharmaceutical Company | Synthesis of peptides |
| IL59690A (en) | 1980-03-24 | 1983-11-30 | Yeda Res & Dev | Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it |
| US4621053A (en) * | 1980-07-30 | 1986-11-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of human peptide hormones |
| US4423037A (en) * | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| WO1988000596A1 (en) * | 1986-07-18 | 1988-01-28 | The University Of Melbourne | A PROTEIN ACTIVE IN HUMORAL HYPERCALCEMIA OF MALIGNANCY-PTHrP |
| EP0604706A1 (en) | 1986-10-22 | 1994-07-06 | GAUTVIK, Kaare M., Dr. | Production of human parathyroid hormone from microorganisms |
| US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
| US4771124A (en) * | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| US5639660A (en) * | 1988-02-24 | 1997-06-17 | Hoffmann-La Roche Inc. | Polypeptide and DNA sequence corresponding to the human receptor with high affinity for IgE |
| US5114843A (en) * | 1988-05-09 | 1992-05-19 | Merck & Co., Inc. | Humoral hypercalcemic factor antagonists |
| US5457047A (en) * | 1989-02-23 | 1995-10-10 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition |
| USRE37919E1 (en) | 1989-05-12 | 2002-12-03 | The General Hospital Corporation | Recombinant DNA method for production of parathyroid hormone |
| CA2040264A1 (en) * | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| JP2952951B2 (ja) * | 1990-04-12 | 1999-09-27 | 三菱化学株式会社 | ペプチド誘導体 |
| WO1992000753A1 (en) * | 1990-07-13 | 1992-01-23 | The Regents Of The University Of California | PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9 |
| US5149779A (en) * | 1990-07-26 | 1992-09-22 | Merck & Co., Inc. | Humoral hypercalcemic factor antagonists |
| US5208041A (en) * | 1991-05-23 | 1993-05-04 | Allelix Biopharmaceuticals Inc. | Essentially pure human parathyroid hormone |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US5849695A (en) * | 1993-01-13 | 1998-12-15 | The Regents Of The University Of California | Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals |
| WO1997027870A1 (fr) * | 1996-02-01 | 1997-08-07 | Chugai Seiyaku Kabushiki Kaisha | Medicaments prevenant ou guerissant la thrombopenie |
| TW505654B (en) * | 1996-07-30 | 2002-10-11 | Hoffmann La Roche | Synthesis of analogs of PTH and PTHrP |
| SE9702401D0 (sv) * | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| AU5877300A (en) * | 1999-06-15 | 2001-01-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Pth2 and pth1 receptor ligands |
| US6387711B1 (en) * | 2000-08-11 | 2002-05-14 | Quest Diagnostics Investments Incorporated | Liquid intact parathyroid hormone (PTH) standards |
| US6905886B2 (en) * | 2000-08-11 | 2005-06-14 | Quest Diagnostics Investments Incorporated | Preservative solutions |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
-
1973
- 1973-12-10 US US423303A patent/US3886132A/en not_active Expired - Lifetime
- 1973-12-20 NL NL7317489A patent/NL7317489A/xx not_active Application Discontinuation
- 1973-12-21 GB GB5932373A patent/GB1413198A/en not_active Expired
- 1973-12-21 CH CH1806573A patent/CH599123A5/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409141A (en) | 1980-12-29 | 1983-10-11 | Toyo Jozo Kabushiki Kaisha | Peptides for assaying human parathyroid hormone |
| USRE33188E (en) * | 1980-12-29 | 1990-03-27 | Toyo Jozo Kabushiki Kaisha | Peptides for assaying human parathyroid hormone |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7317489A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-06-25 |
| US3886132A (en) | 1975-05-27 |
| CH599123A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1413198A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| MORGAN et al. | Nature of the subunits of human chorionic gonadotropin | |
| Sparrow | An improved polystyrene support for solid phase peptide synthesis | |
| Geisler et al. | Purification of smooth‐muscle desmin and a protein‐chemical comparison of desmins from chicken gizzard and hog stomach | |
| Han et al. | Studies on the Primary Structure of Bovine High-MolecularWeight Kininogen: Amino Acid Sequence of a Fragment (“Histidine-Rich Peptide”) Released by Plasma Kallikrein | |
| ATE30033T1 (de) | Verfahren zur herstellung von retro-inverso polypeptiden in fester phase. | |
| AU543198B2 (en) | Hexapeptides | |
| GR3017187T3 (en) | Peptides for the diagnose of HTLV-III antibodies, their preparation and use. | |
| EP0184309A3 (en) | Peptides selected from amino-acid residues 11 to 23 of vip | |
| Tanaka et al. | The amino acid sequence of Clostridium pasteurianum iron protein, a component of nitrogenase. III. The NH2-terminal and COOH-terminal sequences, tryptic peptides of large cyanogen bromide peptides, and the complete sequence | |
| Tregear et al. | Solid-Phase Synthesis of the Biologically Active N-Terminal 1—34 Peptide of Human Parathyroid Hormone | |
| Scott et al. | Purification and characterization of porcine corticotrophin-like intermediate lobe peptide | |
| Felix et al. | SYNTHESIS, BIOLOGICAL ACTIVITY, AND TRITIATION OF L‐3, 4‐DEHYDROPROLINE‐CONTAINING PEPTIDES | |
| ES488382A1 (es) | Procedimiento para la preparacion de lh-rh o de analogos de lh-rh | |
| DE3779711D1 (en) | Simultaneous solid-phase synthesis of different peptide(s) | |
| Sugeno et al. | The amino acid sequence of cytochrome c from Debaryomyces kloeckeri | |
| YAJIMA et al. | Studies on Peptides. XXXII. The Use of N-Ethoxycarbonyl-2-ethoxy-1, 2-dihydro-quinoline as a Coupling Reagent of Peptide-Fragments on Polymer Support | |
| MOKOTOFF et al. | Synthesis of the C‐terminal half of thymosin α1 by the polymeric reagent method | |
| KATSOYANNIS | Synthetic insulins | |
| DE69019077D1 (de) | Verfahren zur herstellung von c-terminalen alpha-amidierten peptiden. | |
| Sowden | Note on the occurrence of amino groups in soil organic matter | |
| D'Alessio et al. | Ribonuclease BS-1: sequence of two cyanogen bromide peptides | |
| Otsuka et al. | The synthesis of an MSH-active tetrapeptide, L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophan | |
| YAJIMA et al. | Studies on peptides. LIX. Synthesis of the nonatriacontapeptide corresponding to the entire amino acid sequence of porcine adrenocorticotropic hormone | |
| Kössel et al. | Studies on polynucleotides: LXXIII. Synthesis in vitro of polypeptides containing repeating tetrapeptide sequences dependent upon DNA-like polymers containing repeating tetranucleotide sequences: Direction of reading of messenger RNA |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |