GB1377209A - Optically active basically substituted phenylacetonitriles - Google Patents
Optically active basically substituted phenylacetonitrilesInfo
- Publication number
- GB1377209A GB1377209A GB5525871A GB5525871A GB1377209A GB 1377209 A GB1377209 A GB 1377209A GB 5525871 A GB5525871 A GB 5525871A GB 5525871 A GB5525871 A GB 5525871A GB 1377209 A GB1377209 A GB 1377209A
- Authority
- GB
- United Kingdom
- Prior art keywords
- och
- cyano
- formula
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007962 benzene acetonitriles Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- KZTKFTBOOWOOHZ-UHFFFAOYSA-N 4-cyano-5-methyl-4-(3,4,5-trimethoxyphenyl)hexanoic acid Chemical compound COC1=CC(C(CCC(O)=O)(C#N)C(C)C)=CC(OC)=C1OC KZTKFTBOOWOOHZ-UHFFFAOYSA-N 0.000 abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- GSFNQBFZFXUTBN-UHFFFAOYSA-N 2-chlorothiophene Chemical compound ClC1=CC=CS1 GSFNQBFZFXUTBN-UHFFFAOYSA-N 0.000 abstract 1
- WDBYIZQQJKMJTR-UHFFFAOYSA-N 2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanedinitrile Chemical compound COC1=CC(C(CCC#N)(C#N)C(C)C)=CC(OC)=C1OC WDBYIZQQJKMJTR-UHFFFAOYSA-N 0.000 abstract 1
- UEXCJVNBTNXOEH-UHFFFAOYSA-N Ethynylbenzene Chemical class C#CC1=CC=CC=C1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- RRKTZKIUPZVBMF-IBTVXLQLSA-N brucine Chemical compound O([C@@H]1[C@H]([C@H]2C3)[C@@H]4N(C(C1)=O)C=1C=C(C(=CC=11)OC)OC)CC=C2CN2[C@@H]3[C@]41CC2 RRKTZKIUPZVBMF-IBTVXLQLSA-N 0.000 abstract 1
- RRKTZKIUPZVBMF-UHFFFAOYSA-N brucine Natural products C1=2C=C(OC)C(OC)=CC=2N(C(C2)=O)C3C(C4C5)C2OCC=C4CN2C5C31CC2 RRKTZKIUPZVBMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007127 saponification reaction Methods 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702059985 DE2059985C3 (de) | 1970-12-05 | 1970-12-05 | Rechtsdrehende, basisch substituierte Phenylacetonitrile, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377209A true GB1377209A (en) | 1974-12-11 |
Family
ID=5790130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5525871A Expired GB1377209A (en) | 1970-12-05 | 1971-11-29 | Optically active basically substituted phenylacetonitriles |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT305263B (fr) |
| BE (1) | BE776219A (fr) |
| CH (1) | CH565747A5 (fr) |
| DE (1) | DE2059985C3 (fr) |
| FR (1) | FR2116565B1 (fr) |
| GB (1) | GB1377209A (fr) |
| NL (1) | NL172649C (fr) |
| YU (2) | YU35347B (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438131A (en) | 1981-04-10 | 1984-03-20 | Basf Aktiengesellschaft | Ω-Cyano-1, Ω-diphenyl-azaalkane derivatives, their preparation and drugs containing them |
| US4596820A (en) * | 1983-12-10 | 1986-06-24 | Basf Aktiengesellschaft | 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane for use in the treatment of diseases |
| US4968717A (en) * | 1986-01-31 | 1990-11-06 | Basf Aktiengesellschaft | Phenylacetonitriles which are substituted by basic groups, their preparation and drugs containing these substances |
| US5786498A (en) * | 1995-01-31 | 1998-07-28 | Basf Aktiengesellschaft | Resolution of racemates of 2-aryl-2-alkyl-ω-alkylaminoalkane-nitriles |
| EP1167348A1 (fr) * | 1999-03-16 | 2002-01-02 | Eisai Co., Ltd. | Derives de nitrile |
| US7803962B2 (en) | 2007-06-07 | 2010-09-28 | Cosma S.P.A. | Process for the resolution of racemic verapamil |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3635930A1 (de) * | 1986-10-22 | 1988-04-28 | Basf Ag | Wirkstoffe zur anwendung bei der behandlung von tumoren |
| DE3603660C2 (de) * | 1986-02-06 | 1994-09-15 | Fresenius Ag | Verbesserte Peritonealdialyse |
| DE3635931A1 (de) * | 1986-10-22 | 1988-04-28 | Basf Ag | Wirkstoffe zur verhuetung von tumormetastasen |
| AU3205497A (en) * | 1996-05-23 | 1997-12-09 | G.D. Searle & Co. | Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of r- and s-verapamil |
-
1970
- 1970-12-05 DE DE19702059985 patent/DE2059985C3/de not_active Expired
-
1971
- 1971-11-26 CH CH1728671A patent/CH565747A5/xx not_active IP Right Cessation
- 1971-11-29 GB GB5525871A patent/GB1377209A/en not_active Expired
- 1971-12-01 AT AT1035471A patent/AT305263B/de not_active IP Right Cessation
- 1971-12-01 YU YU302471A patent/YU35347B/xx unknown
- 1971-12-03 BE BE776219A patent/BE776219A/fr not_active IP Right Cessation
- 1971-12-03 NL NL7116663A patent/NL172649C/xx not_active IP Right Cessation
- 1971-12-06 FR FR7143745A patent/FR2116565B1/fr not_active Expired
-
1979
- 1979-02-01 YU YU21979A patent/YU35349B/xx unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438131A (en) | 1981-04-10 | 1984-03-20 | Basf Aktiengesellschaft | Ω-Cyano-1, Ω-diphenyl-azaalkane derivatives, their preparation and drugs containing them |
| US4596820A (en) * | 1983-12-10 | 1986-06-24 | Basf Aktiengesellschaft | 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane for use in the treatment of diseases |
| AU569354B2 (en) * | 1983-12-10 | 1988-01-28 | Basf Aktiengesellschaft | (-)-1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane |
| US4968717A (en) * | 1986-01-31 | 1990-11-06 | Basf Aktiengesellschaft | Phenylacetonitriles which are substituted by basic groups, their preparation and drugs containing these substances |
| US5786498A (en) * | 1995-01-31 | 1998-07-28 | Basf Aktiengesellschaft | Resolution of racemates of 2-aryl-2-alkyl-ω-alkylaminoalkane-nitriles |
| EP1167348A1 (fr) * | 1999-03-16 | 2002-01-02 | Eisai Co., Ltd. | Derives de nitrile |
| EP1167348A4 (fr) * | 1999-03-16 | 2002-11-13 | Eisai Co Ltd | Derives de nitrile |
| US6667412B1 (en) | 1999-03-16 | 2003-12-23 | Eisai Co., Ltd. | Nitrile compound |
| US7803962B2 (en) | 2007-06-07 | 2010-09-28 | Cosma S.P.A. | Process for the resolution of racemic verapamil |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2116565B1 (fr) | 1975-06-13 |
| DE2059985A1 (de) | 1972-06-15 |
| FR2116565A1 (fr) | 1972-07-13 |
| CH565747A5 (fr) | 1975-08-29 |
| BE776219A (fr) | 1972-06-05 |
| NL7116663A (fr) | 1972-06-07 |
| YU35349B (en) | 1980-12-31 |
| DE2059985C3 (de) | 1979-10-04 |
| YU302471A (en) | 1980-06-30 |
| NL172649B (nl) | 1983-05-02 |
| YU21979A (en) | 1980-06-30 |
| NL172649C (nl) | 1983-10-03 |
| AT305263B (de) | 1973-02-26 |
| DE2059985B2 (de) | 1979-02-15 |
| YU35347B (en) | 1980-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |