GB1377074A - Process for preparing injectable compositions - Google Patents
Process for preparing injectable compositionsInfo
- Publication number
- GB1377074A GB1377074A GB3278071A GB3278071A GB1377074A GB 1377074 A GB1377074 A GB 1377074A GB 3278071 A GB3278071 A GB 3278071A GB 3278071 A GB3278071 A GB 3278071A GB 1377074 A GB1377074 A GB 1377074A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allergen
- solution
- tyrosine
- particles
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000013566 allergen Substances 0.000 abstract 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000011859 microparticle Substances 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 241000282326 Felis catus Species 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002009 allergenic effect Effects 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3278071A GB1377074A (en) | 1971-07-13 | 1971-07-13 | Process for preparing injectable compositions |
| IE859/72A IE36426B1 (en) | 1971-07-13 | 1972-06-20 | Process for preparing injectable compositions |
| ZA724557A ZA724557B (en) | 1971-07-13 | 1972-07-03 | Process for preparing injectionable compositions |
| CA146,522A CA973093A (en) | 1971-07-13 | 1972-07-06 | Process for preparing injectionable compositions |
| BE786026D BE786026A (fr) | 1971-07-13 | 1972-07-07 | Procede pour la preparation de compositions injectables |
| NLAANVRAGE7209574,A NL176431C (nl) | 1971-07-13 | 1972-07-10 | Werkwijze voor het bereiden van microdeeltjes van tyrosine met daarin gedispergeerd allergeen, alsmede een injecteerbare samenstelling op basis daarvan. |
| FR7224888A FR2145555B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-13 | 1972-07-10 | |
| US00270086A US3792159A (en) | 1971-07-13 | 1972-07-10 | Process for preparing injectionable compositions |
| ES404748A ES404748A1 (es) | 1971-07-13 | 1972-07-11 | Un procedimiento para la preparacion de microparticulas finamente devididas de tirosina. |
| JP6986172A JPS5549572B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-13 | 1972-07-12 | |
| DK346972AA DK130455B (da) | 1971-07-13 | 1972-07-12 | Fremgangsmåde til fremstilling af findelte - eventuelt i en bærer suspenderede - mikropartikler af tyrosin med et allergen dispergeret deri. |
| SE7209208A SE385770B (sv) | 1971-07-13 | 1972-07-12 | Sett att framstella allergenhaltiga mikropartiklar av tyrosin |
| AU44505/72A AU462878B2 (en) | 1971-07-13 | 1972-07-12 | Process for preparing injectionable compositions |
| DE2234474A DE2234474C3 (de) | 1971-07-13 | 1972-07-13 | Verfahren zur Herstellung fein verteilter Mikropartikel von Tyrosin mit einem Gehalt eines darin dispergierten Allergens und diese Produkte enthaltende Arzneipräparate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3278071A GB1377074A (en) | 1971-07-13 | 1971-07-13 | Process for preparing injectable compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377074A true GB1377074A (en) | 1974-12-11 |
Family
ID=10343893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3278071A Expired GB1377074A (en) | 1971-07-13 | 1971-07-13 | Process for preparing injectable compositions |
Country Status (14)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044947A1 (en) * | 1997-04-05 | 1998-10-15 | Allergy Therapeutics Limited | Allergen formulation |
| US6440426B1 (en) | 1998-09-21 | 2002-08-27 | Allergy Therapeutics Limited | Antigen-containing formulation and methods of use thereof |
| US8470331B2 (en) | 2000-01-14 | 2013-06-25 | Allergy Therapeutics (Uk) Limited | Composition of antigen and glycolipid adjuvant for sublingual administration |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1492973A (en) * | 1974-02-16 | 1977-11-23 | Beecham Group Ltd | Process for preparing injectable compositions |
| US4070455A (en) * | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| US4258029A (en) * | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
| US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
| US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| GB9508785D0 (en) * | 1995-04-29 | 1995-06-21 | Smithkline Beecham Plc | Novel compositions |
| ES2287116T3 (es) * | 2000-04-07 | 2007-12-16 | Signal Coordinating Therapy, Inc. | Procedimientos y composiciones para tratar neoplasmas. |
-
1971
- 1971-07-13 GB GB3278071A patent/GB1377074A/en not_active Expired
-
1972
- 1972-06-20 IE IE859/72A patent/IE36426B1/xx unknown
- 1972-07-03 ZA ZA724557A patent/ZA724557B/xx unknown
- 1972-07-06 CA CA146,522A patent/CA973093A/en not_active Expired
- 1972-07-07 BE BE786026D patent/BE786026A/xx not_active IP Right Cessation
- 1972-07-10 US US00270086A patent/US3792159A/en not_active Expired - Lifetime
- 1972-07-10 NL NLAANVRAGE7209574,A patent/NL176431C/xx not_active IP Right Cessation
- 1972-07-10 FR FR7224888A patent/FR2145555B1/fr not_active Expired
- 1972-07-11 ES ES404748A patent/ES404748A1/es not_active Expired
- 1972-07-12 JP JP6986172A patent/JPS5549572B1/ja active Pending
- 1972-07-12 AU AU44505/72A patent/AU462878B2/en not_active Expired
- 1972-07-12 DK DK346972AA patent/DK130455B/da not_active IP Right Cessation
- 1972-07-12 SE SE7209208A patent/SE385770B/xx unknown
- 1972-07-13 DE DE2234474A patent/DE2234474C3/de not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044947A1 (en) * | 1997-04-05 | 1998-10-15 | Allergy Therapeutics Limited | Allergen formulation |
| US7718178B2 (en) | 1997-04-05 | 2010-05-18 | Allergy Therapeutics Limited | Allergen formulation |
| US8105605B2 (en) | 1997-04-05 | 2012-01-31 | Allergy Therapeutics (Uk) Ltd. | Allergen formulation |
| US6440426B1 (en) | 1998-09-21 | 2002-08-27 | Allergy Therapeutics Limited | Antigen-containing formulation and methods of use thereof |
| US7815920B2 (en) | 1998-09-21 | 2010-10-19 | Allergy Therapeutics (UK) Ltd | Method of preparing an antigen-containing formulation |
| US8470331B2 (en) | 2000-01-14 | 2013-06-25 | Allergy Therapeutics (Uk) Limited | Composition of antigen and glycolipid adjuvant for sublingual administration |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2234474A1 (de) | 1973-01-25 |
| DK130455B (da) | 1975-02-24 |
| BE786026A (fr) | 1973-01-08 |
| DE2234474B2 (de) | 1980-07-24 |
| JPS5549572B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-12-12 |
| FR2145555A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-02-23 |
| CA973093A (en) | 1975-08-19 |
| AU4450572A (en) | 1974-01-17 |
| NL176431B (nl) | 1984-11-16 |
| ZA724557B (en) | 1973-07-25 |
| IE36426B1 (en) | 1976-10-27 |
| ES404748A1 (es) | 1975-07-01 |
| AU462878B2 (en) | 1975-07-10 |
| US3792159A (en) | 1974-02-12 |
| FR2145555B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-05-14 |
| NL7209574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-01-16 |
| IE36426L (en) | 1973-01-13 |
| SE385770B (sv) | 1976-07-26 |
| NL176431C (nl) | 1985-04-16 |
| DK130455C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-07-21 |
| DE2234474C3 (de) | 1981-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1377074A (en) | Process for preparing injectable compositions | |
| Banks et al. | Reactions of cytochrome-c with methyl linoleate hydroperoxide | |
| DK74187D0 (da) | Praeparat til langsom frigivelse samt fremgangsmaade til fremstilling deraf | |
| ES440893A1 (es) | Procedimiento para la preparacion de un granulado de pigmen-to facilmente aislable, no polvoroso y bien dispersable. | |
| Huff et al. | The probable identity of Najjar and Holt's fluorescent substance, F2 | |
| ZA832044B (en) | Imidazolyphenyl-tetrahydropyridazines,processes for their preparation and pharmaceutical preparation containing them | |
| TW358028B (en) | Process for production of flavanolignan preparation with improved liberation and resorbability preparations obtainable according to this process and pharmaceutical compositions containing them | |
| GB1263000A (en) | 4,4',4''-trihydroxytriphenylmethylmethane and process for preparing it | |
| GB1403242A (en) | Aluminium phosphate gel | |
| GB1492973A (en) | Process for preparing injectable compositions | |
| ES450075A1 (es) | Un metodo de preparacion de derivados de bis-triazinilamino-estilbeno. | |
| ES399906A1 (es) | Procedimiento para componer preparados colorantes. | |
| GB1456332A (en) | Process for the purification of azo pigments | |
| GB1240130A (en) | Slow-release adsorbed allergens | |
| GB1140316A (en) | Influenza virus sub-unit vaccine | |
| US3122578A (en) | Complexes of tetracycline antibiotics and preparation of same | |
| Flesch et al. | The iron pigment of red hair and feathers | |
| GB1394045A (en) | Method of producing a carrier for serological reactions | |
| GB1514402A (en) | Process for the preparation of saturated omega-amino-acids from olefinically unsaturated omega-aldehydoacids | |
| SU619188A1 (ru) | Способ получени препарата гонадотропинов из сыворотки жеребых кобыл "оваритропина" | |
| Grinnan | Highly polymerized liver ribonucleic acid: physico-chemical studies and cytoplasmic localization | |
| GB737961A (en) | Method for the production of insulin preparations with protracted effect | |
| GB1005821A (en) | New antibiotic compositions | |
| GB736371A (en) | Improvements in or relating to methods of producing stable aqueous solutions containing vitamin b | |
| GB1478460A (en) | Method of preparing glucopeptides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |