GB1347665A - Process for the production of cephalexin - Google Patents
Process for the production of cephalexinInfo
- Publication number
- GB1347665A GB1347665A GB3858772A GB3858772A GB1347665A GB 1347665 A GB1347665 A GB 1347665A GB 3858772 A GB3858772 A GB 3858772A GB 3858772 A GB3858772 A GB 3858772A GB 1347665 A GB1347665 A GB 1347665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylglycine
- enzyme
- cellulose
- enzyme preparations
- nrrl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title abstract 4
- 229940106164 cephalexin Drugs 0.000 title abstract 3
- 229940079919 digestives enzyme preparation Drugs 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 229940088598 enzyme Drugs 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 3
- 241000590020 Achromobacter Species 0.000 abstract 2
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 2
- 241000607598 Vibrio Species 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 235000010633 broth Nutrition 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000004927 clay Substances 0.000 abstract 2
- KIYRSYYOVDHSPG-SSDOTTSWSA-N (2r)-2-amino-2-phenylacetamide Chemical compound NC(=O)[C@H](N)C1=CC=CC=C1 KIYRSYYOVDHSPG-SSDOTTSWSA-N 0.000 abstract 1
- LJXOMNKURQBXLP-SECBINFHSA-N 2-[[(2r)-2-azaniumyl-2-phenylacetyl]amino]acetate Chemical compound OC(=O)CNC(=O)[C@H](N)C1=CC=CC=C1 LJXOMNKURQBXLP-SECBINFHSA-N 0.000 abstract 1
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 abstract 1
- 241000588986 Alcaligenes Species 0.000 abstract 1
- 241000588813 Alcaligenes faecalis Species 0.000 abstract 1
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000194107 Bacillus megaterium Species 0.000 abstract 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 241000589565 Flavobacterium Species 0.000 abstract 1
- 241000589580 Flavobacterium aquatile Species 0.000 abstract 1
- 239000005909 Kieselgur Substances 0.000 abstract 1
- 241000736107 Novosphingobium capsulatum Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229940005347 alcaligenes faecalis Drugs 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 abstract 1
- BHFLUDRTVIDDOR-MRVPVSSYSA-N methyl (2r)-2-amino-2-phenylacetate Chemical group COC(=O)[C@H](N)C1=CC=CC=C1 BHFLUDRTVIDDOR-MRVPVSSYSA-N 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP46063715A JPS5231436B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-08-20 | 1971-08-20 | |
| JP640772A JPS552958B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-01-14 | 1972-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1347665A true GB1347665A (en) | 1974-02-20 |
Family
ID=26340537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3858772A Expired GB1347665A (en) | 1971-08-20 | 1972-08-18 | Process for the production of cephalexin |
Country Status (12)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5231035B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-08-22 | 1977-08-12 | ||
| FR2440402B1 (fr) * | 1978-10-30 | 1981-08-14 | Inst Nat Rech Chimique | Procede d'immobilisation de micro-organismes et ses applications |
| IT1274658B (it) * | 1995-02-28 | 1997-07-18 | Acs Dobfar Spa | Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine |
-
1972
- 1972-08-18 HU HUTO000884 patent/HU164997B/hu unknown
- 1972-08-18 GB GB3858772A patent/GB1347665A/en not_active Expired
- 1972-08-18 CA CA150,260A patent/CA986440A/en not_active Expired
- 1972-08-18 SE SE1072172A patent/SE404928B/xx unknown
- 1972-08-18 FR FR7229647A patent/FR2150380B1/fr not_active Expired
- 1972-08-19 CH CH1231972A patent/CH588496A5/xx not_active IP Right Cessation
- 1972-08-21 AU AU45781/72A patent/AU445437B2/en not_active Expired
- 1972-08-21 AT AT719272A patent/AT324548B/de not_active IP Right Cessation
- 1972-08-21 DE DE19722241091 patent/DE2241091B2/de active Granted
- 1972-08-21 NL NL7211406A patent/NL7211406A/xx not_active Application Discontinuation
- 1972-08-21 DD DD16516072A patent/DD101166A5/xx unknown
- 1972-08-21 BE BE787793A patent/BE787793A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU445437B2 (en) | 1974-02-21 |
| SE404928B (sv) | 1978-11-06 |
| FR2150380B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-10-04 |
| FR2150380A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-04-06 |
| DE2241091A1 (de) | 1973-03-15 |
| AT324548B (de) | 1975-09-10 |
| HU164997B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-05-28 |
| CA986440A (en) | 1976-03-30 |
| BE787793A (fr) | 1972-12-18 |
| DE2241091B2 (de) | 1976-02-05 |
| AU4578172A (en) | 1974-02-21 |
| NL7211406A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-02-22 |
| CH588496A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-06-15 |
| DD101166A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |