GB1333359A - Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application - Google Patents
Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic applicationInfo
- Publication number
- GB1333359A GB1333359A GB2537272A GB2537272A GB1333359A GB 1333359 A GB1333359 A GB 1333359A GB 2537272 A GB2537272 A GB 2537272A GB 2537272 A GB2537272 A GB 2537272A GB 1333359 A GB1333359 A GB 1333359A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- ethoxycarbonyl
- hydroxy
- derivatives
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- -1 ethoxycarbonylmethyl Chemical group 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- COUJQDCXQPRAKR-UHFFFAOYSA-N 4-(piperazin-1-ylmethyl)-1h-indole Chemical class C=1C=CC=2NC=CC=2C=1CN1CCNCC1 COUJQDCXQPRAKR-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- BSNHKSUAAMJXBB-UHFFFAOYSA-N ethyl 5-hydroxy-2-methyl-1h-indole-3-carboxylate Chemical compound C1=C(O)C=C2C(C(=O)OCC)=C(C)NC2=C1 BSNHKSUAAMJXBB-UHFFFAOYSA-N 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7120476A FR2140260B1 (https=) | 1971-06-07 | 1971-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1333359A true GB1333359A (en) | 1973-10-10 |
Family
ID=9078186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2537272A Expired GB1333359A (en) | 1971-06-07 | 1972-05-31 | Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5132632B1 (https=) |
| BE (1) | BE784196A (https=) |
| CA (1) | CA954862A (https=) |
| CH (1) | CH540918A (https=) |
| DE (1) | DE2227487C3 (https=) |
| ES (1) | ES403546A1 (https=) |
| FR (1) | FR2140260B1 (https=) |
| GB (1) | GB1333359A (https=) |
| IT (1) | IT1051252B (https=) |
| LU (1) | LU65463A1 (https=) |
| NL (1) | NL7207639A (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
-
1971
- 1971-06-07 FR FR7120476A patent/FR2140260B1/fr not_active Expired
-
1972
- 1972-05-31 BE BE784196A patent/BE784196A/xx unknown
- 1972-05-31 GB GB2537272A patent/GB1333359A/en not_active Expired
- 1972-06-02 CH CH821272A patent/CH540918A/fr not_active IP Right Cessation
- 1972-06-05 LU LU65463D patent/LU65463A1/xx unknown
- 1972-06-06 CA CA144,052*7A patent/CA954862A/en not_active Expired
- 1972-06-06 DE DE19722227487 patent/DE2227487C3/de not_active Expired
- 1972-06-06 ES ES403546A patent/ES403546A1/es not_active Expired
- 1972-06-06 JP JP5568472A patent/JPS5132632B1/ja active Pending
- 1972-06-06 NL NL7207639A patent/NL7207639A/xx not_active Application Discontinuation
- 1972-06-07 IT IT6880272A patent/IT1051252B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| CA954862A (en) | 1974-09-17 |
| IT1051252B (it) | 1981-04-21 |
| NL7207639A (https=) | 1972-12-11 |
| CH540918A (fr) | 1973-08-31 |
| FR2140260B1 (https=) | 1974-08-30 |
| DE2227487C3 (de) | 1978-03-16 |
| DE2227487B2 (de) | 1977-06-30 |
| DE2227487A1 (de) | 1972-12-21 |
| FR2140260A1 (https=) | 1973-01-19 |
| LU65463A1 (https=) | 1973-01-22 |
| JPS5132632B1 (https=) | 1976-09-14 |
| BE784196A (fr) | 1972-11-30 |
| ES403546A1 (es) | 1975-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |