GB1323170A - N,n-diacylhydrazine derivatives and preparation - Google Patents

N,n-diacylhydrazine derivatives and preparation

Info

Publication number
GB1323170A
GB1323170A GB6117870A GB6117870A GB1323170A GB 1323170 A GB1323170 A GB 1323170A GB 6117870 A GB6117870 A GB 6117870A GB 6117870 A GB6117870 A GB 6117870A GB 1323170 A GB1323170 A GB 1323170A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
derivatives
carboxylic
acyl radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6117870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1323170A publication Critical patent/GB1323170A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)

Abstract

1323170 N,N<SP>1</SP>-Diacylhydrazine derivatives RICHTER GEDEON VEGYESZETI GYAR RT 23 Dec 1970 [29 Dec 1969] 61178/70 Heading C2C The invention comprises N,N<SP>1</SP>-diacylhydrazine derivatives of the Formula I wherein X is H or a carboxylic acyl radical, R is H or a substituted or unsubstituted alkyl, aryl or aralkyl group, and Ac is the acyl radical of a substituted or unsubstituted aliphatic, aromatic or heterocyclic carboxylic acid and the pharmaceutically acceptable acid addition salts of those compounds containing a sufficiently basic nitrogen atom, and the optically active isomers of such compounds containing an asymmetric carbon atom. The compounds are prepared by (a) reacting α-aminoxy carboxylic acid derivatives of the Formula II wherein A is a carboxylic acyl radical, or when an end product X is H, A is a radical which protects the amino group, and B is OH or reactive functional derivative thereof, with hydrazides of the Formula III or (b) reacting α-aminoxy carboxylic acid hydrides of the Formula IV with carboxylic acids or reactive functional derivatives thereof of the Formula V and optionally converting the resulting compounds of the Formula VI obtained by either of the reactions mentioned above, into compounds of Formula I by removing the protective group A, and, if desired, acylating the resulting free amino group. Pharmaceutical compositions, suitable for oral, parenteral or rectal administration, contain the above novel compounds or acid addition salts thereof and suitable excipients or carriers. The compounds possess tuberculostatic activity.
GB6117870A 1969-12-29 1970-12-23 N,n-diacylhydrazine derivatives and preparation Expired GB1323170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI000383 1969-12-29

Publications (1)

Publication Number Publication Date
GB1323170A true GB1323170A (en) 1973-07-11

Family

ID=11000832

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6117870A Expired GB1323170A (en) 1969-12-29 1970-12-23 N,n-diacylhydrazine derivatives and preparation

Country Status (15)

Country Link
AT (1) AT299950B (en)
BE (1) BE760980A (en)
CA (1) CA923500A (en)
CH (1) CH562206A5 (en)
CS (1) CS166746B2 (en)
DE (1) DE2064113C3 (en)
ES (1) ES386862A1 (en)
FI (1) FI53816C (en)
GB (1) GB1323170A (en)
IL (1) IL35930A (en)
NL (1) NL7018972A (en)
NO (1) NO132394C (en)
PL (1) PL82652B1 (en)
SE (1) SE385478B (en)
SU (1) SU383282A3 (en)

Also Published As

Publication number Publication date
AT299950B (en) 1972-07-10
SU383282A3 (en) 1973-05-25
DE2064113B2 (en) 1974-07-04
DE2064113A1 (en) 1971-07-22
CS166746B2 (en) 1976-03-29
FI53816B (en) 1978-05-02
NO132394B (en) 1975-07-28
ES386862A1 (en) 1973-04-16
NL7018972A (en) 1971-07-01
IL35930A0 (en) 1971-02-25
BE760980A (en) 1971-05-27
PL82652B1 (en) 1975-10-31
CA923500A (en) 1973-03-27
IL35930A (en) 1974-06-30
CH562206A5 (en) 1975-05-30
NO132394C (en) 1975-11-05
DE2064113C3 (en) 1975-02-20
SE385478B (en) 1976-07-05
FI53816C (en) 1978-08-10

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee