GB1310120A - Azepine derivative its preparation and composition containing it - Google Patents
Azepine derivative its preparation and composition containing itInfo
- Publication number
- GB1310120A GB1310120A GB1111170A GB1111170A GB1310120A GB 1310120 A GB1310120 A GB 1310120A GB 1111170 A GB1111170 A GB 1111170A GB 1111170 A GB1111170 A GB 1111170A GB 1310120 A GB1310120 A GB 1310120A
- Authority
- GB
- United Kingdom
- Prior art keywords
- azepine
- preparation
- composition containing
- dibenz
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001538 azepines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- JGDFBJMWFLXCLJ-UHFFFAOYSA-N copper chromite Chemical compound [Cu]=O.[Cu]=O.O=[Cr]O[Cr]=O JGDFBJMWFLXCLJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical compound C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 abstract 1
- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH484469A CH505101A (de) | 1969-03-31 | 1969-03-31 | Verfahren zur Herstellung von neuen Azepinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1310120A true GB1310120A (en) | 1973-03-14 |
Family
ID=4283538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1111170A Expired GB1310120A (en) | 1969-03-31 | 1970-03-09 | Azepine derivative its preparation and composition containing it |
Country Status (20)
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002250A1 (en) * | 1995-06-30 | 1997-01-23 | Portela & Ca., S.A. | 10-ACYLOXY-10,11-DIHYDRODIBENZ/b,f/AZEPINE-5-CARBOXAMIDES USEFUL FOR TREATING NERVOUS SYSTEM DISORDERS |
| WO2003042182A1 (en) | 2001-11-12 | 2003-05-22 | Novartis Ag | Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain |
| WO2004071513A1 (en) * | 2003-02-17 | 2004-08-26 | Novartis Ag | Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain |
| US7037525B2 (en) | 1997-02-14 | 2006-05-02 | Novartis Ag | Oxacarbazepine film-coated tablets |
| WO2006053674A3 (en) * | 2004-11-19 | 2006-09-14 | Farchemia Srl | A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide |
| US9763954B2 (en) | 2007-01-15 | 2017-09-19 | Bial—Portela & Ca, S.A. | Therapeutical uses of eslicarbazepine |
| US10675287B2 (en) | 2005-05-06 | 2020-06-09 | Bial-Portela & Ca S.A. | Methods of treatment of partial onset seizures using eslicarbazepine acetate |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789320A (fr) * | 1971-09-30 | 1973-03-27 | Takeda Chemical Industries Ltd | Derives de dibenzoxirenazepine |
| EP0108715A1 (de) * | 1982-10-15 | 1984-05-16 | Ciba-Geigy Ag | Dibenzazepincarboxamide |
| AT408224B (de) * | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxcarbazepin |
-
1969
- 1969-03-31 CH CH484469A patent/CH505101A/de not_active IP Right Cessation
-
1970
- 1970-03-03 NL NL7003026.A patent/NL159972C/xx not_active IP Right Cessation
- 1970-03-03 SE SE02771/70A patent/SE354069B/xx unknown
- 1970-03-03 DK DK104670AA patent/DK133898B/da not_active IP Right Cessation
- 1970-03-03 BR BR217333/70A patent/BR7017333D0/pt unknown
- 1970-03-03 FI FI700560A patent/FI50524C/fi active
- 1970-03-05 YU YU537/70A patent/YU33863B/xx unknown
- 1970-03-09 DE DE2011045A patent/DE2011045C3/de not_active Expired
- 1970-03-09 NO NO70757A patent/NO131546C/no unknown
- 1970-03-09 AT AT218670A patent/AT294106B/de not_active IP Right Cessation
- 1970-03-09 IL IL34027A patent/IL34027A/xx unknown
- 1970-03-09 IE IE303/70A patent/IE34050B1/xx unknown
- 1970-03-09 BG BG014134A patent/BG17600A3/xx unknown
- 1970-03-09 ES ES377280A patent/ES377280A1/es not_active Expired
- 1970-03-09 FR FR707008345A patent/FR2035999B1/fr not_active Expired
- 1970-03-09 BE BE747086D patent/BE747086A/xx not_active IP Right Cessation
- 1970-03-09 CA CA076788A patent/CA920587A/en not_active Expired
- 1970-03-09 GB GB1111170A patent/GB1310120A/en not_active Expired
- 1970-03-09 CS CS155770A patent/CS154295B2/cs unknown
- 1970-03-09 PL PL1970139289A patent/PL80544B1/pl unknown
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753646A (en) * | 1995-06-30 | 1998-05-19 | Portela & Ca., S.A. | Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them |
| RU2168502C2 (ru) * | 1995-06-30 | 2001-06-10 | Портела энд Ка., С.А. | Замещенные дигидродибенз/b, f/азепины, способ их получения, фармацевтическая композиция, обладающая антиэпилептической активностью |
| CN1070853C (zh) * | 1995-06-30 | 2001-09-12 | 波特拉和卡公司 | 用于治疗神经系统疾病的10-酰氧基-10,11-二氢二苯并/b,f/氮杂䓬-5-甲酰胺 |
| WO1997002250A1 (en) * | 1995-06-30 | 1997-01-23 | Portela & Ca., S.A. | 10-ACYLOXY-10,11-DIHYDRODIBENZ/b,f/AZEPINE-5-CARBOXAMIDES USEFUL FOR TREATING NERVOUS SYSTEM DISORDERS |
| US7037525B2 (en) | 1997-02-14 | 2006-05-02 | Novartis Ag | Oxacarbazepine film-coated tablets |
| CN100506797C (zh) * | 2001-11-12 | 2009-07-01 | 诺瓦提斯公司 | 用于制备治疗情感和注意障碍以及神经性疼痛的药物的单羟基卡马西平 |
| WO2003042182A1 (en) | 2001-11-12 | 2003-05-22 | Novartis Ag | Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain |
| JP2005511623A (ja) * | 2001-11-12 | 2005-04-28 | ノバルティス アクチエンゲゼルシャフト | 情動および注意障害、神経因性疼痛の処置用医薬の製造において使用するためのモノヒドロキシカルバマゼピン |
| EP2048135A1 (en) | 2001-11-12 | 2009-04-15 | Novartis AG | Use of monohydroxycarbamazepine in the treatment of neuropathic pain and related disorders |
| AU2007201925B2 (en) * | 2001-11-12 | 2009-06-04 | Novartis Ag | Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain |
| WO2004071513A1 (en) * | 2003-02-17 | 2004-08-26 | Novartis Ag | Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain |
| WO2006053674A3 (en) * | 2004-11-19 | 2006-09-14 | Farchemia Srl | A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide |
| US7858778B2 (en) | 2004-11-19 | 2010-12-28 | Farchemia S.R.L. | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[B,F]azepine-5-carboxyamide |
| US10675287B2 (en) | 2005-05-06 | 2020-06-09 | Bial-Portela & Ca S.A. | Methods of treatment of partial onset seizures using eslicarbazepine acetate |
| US10695354B2 (en) | 2005-05-06 | 2020-06-30 | Bial-Portela & Ca S.A. | Methods of treatment of partial onset seizures using eslicarbazepine acetate |
| US10702536B2 (en) | 2005-05-06 | 2020-07-07 | Bial-Portela & Ca S.A. | Methods of treatment of partial onset seizures using eslicarbazepine acetate |
| US11364247B2 (en) | 2005-05-06 | 2022-06-21 | Bial-Portela & Ca S.A. | Methods of treatment of partial onset seizures using eslicarbazepine acetate |
| US9763954B2 (en) | 2007-01-15 | 2017-09-19 | Bial—Portela & Ca, S.A. | Therapeutical uses of eslicarbazepine |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |