GB1260868A - 0,2,3,6-tetrasubstituted indoles - Google Patents
0,2,3,6-tetrasubstituted indolesInfo
- Publication number
- GB1260868A GB1260868A GB0982/69A GB198269A GB1260868A GB 1260868 A GB1260868 A GB 1260868A GB 0982/69 A GB0982/69 A GB 0982/69A GB 198269 A GB198269 A GB 198269A GB 1260868 A GB1260868 A GB 1260868A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- cyclizing
- aniline
- sept
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 229910004373 HOAc Inorganic materials 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR135641A FR7337M (forum.php) | 1968-01-11 | 1968-01-11 | |
| FR147662 | 1968-04-10 | ||
| FR165689 | 1968-09-10 | ||
| FR165812A FR1584808A (forum.php) | 1968-01-11 | 1968-09-11 | |
| FR75177430A FR8438M (forum.php) | 1968-12-10 | 1968-12-10 | |
| FR75177431A FR8439M (forum.php) | 1968-12-10 | 1968-12-10 | |
| FR696931578A FR2062869B2 (forum.php) | 1968-01-11 | 1969-09-17 | |
| US7285970A | 1970-09-16 | 1970-09-16 | |
| US00272375A US3856967A (en) | 1968-01-11 | 1972-07-17 | Novel indoles in the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1260868A true GB1260868A (en) | 1972-01-19 |
Family
ID=27576177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0982/69A Expired GB1260868A (en) | 1968-01-11 | 1969-01-13 | 0,2,3,6-tetrasubstituted indoles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3856967A (forum.php) |
| BE (1) | BE726610A (forum.php) |
| CH (1) | CH506523A (forum.php) |
| FR (3) | FR7337M (forum.php) |
| GB (1) | GB1260868A (forum.php) |
| LU (1) | LU57758A1 (forum.php) |
| NL (1) | NL141187B (forum.php) |
| OA (1) | OA03363A (forum.php) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0054417A1 (en) * | 1980-12-15 | 1982-06-23 | Pfizer Limited | Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them |
| US4478819A (en) * | 1982-04-26 | 1984-10-23 | Roussel Rclaf | Novel oral preparations |
| US4814501A (en) * | 1987-12-28 | 1989-03-21 | Merck & Co., Inc. | Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs |
| WO1993005019A1 (en) * | 1991-09-11 | 1993-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as 5-alpha-reductase inhibitor |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7337M (forum.php) * | 1968-01-11 | 1969-10-13 | ||
| FR2096868B1 (forum.php) * | 1970-07-08 | 1974-02-01 | Roussel Uclaf | |
| US4233312A (en) * | 1976-01-21 | 1980-11-11 | Roussel Uclaf | Esters of indole-1-acetic acid and analgesic use thereof |
| FR2338704A1 (fr) * | 1976-01-21 | 1977-08-19 | Roussel Uclaf | Nouveaux indoles substitues, leur procede de preparation et leur application comme medicament |
| US4478842A (en) * | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| IN163263B (forum.php) * | 1984-02-07 | 1988-08-27 | Pfizer | |
| US4721712A (en) * | 1984-06-12 | 1988-01-26 | Pfizer Inc. | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| US4808601A (en) * | 1984-09-19 | 1989-02-28 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US4690943A (en) * | 1984-09-19 | 1987-09-01 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US5312829A (en) * | 1990-05-21 | 1994-05-17 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
| GB9011335D0 (en) * | 1990-05-21 | 1990-07-11 | Fujisawa Pharmaceutical Co | Indolebutyric acid derivatives and process for preparation thereof |
| GB9204024D0 (en) * | 1992-02-25 | 1992-04-08 | Fujisawa Pharmaceutical Co | Indole derivatives |
| WO2003105847A1 (en) * | 2002-06-14 | 2003-12-24 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| US7960544B2 (en) * | 2005-12-16 | 2011-06-14 | Ironwood Pharmaceuticals, Inc. | Useful indole compounds |
| MX2009001327A (es) | 2006-08-07 | 2009-06-05 | Ironwood Pharmaceuticals Inc | Compuestos de indol. |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| CN103086943B (zh) * | 2011-11-04 | 2015-04-15 | 山东亨利医药科技有限责任公司 | 作为crth2受体拮抗剂的吲哚类衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1492929A (fr) * | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation |
| US3505354A (en) * | 1967-05-18 | 1970-04-07 | Geigy Chem Corp | 2-methyl-3-p-halobenzoylindole-n-aliphatic acids |
| FR7337M (forum.php) * | 1968-01-11 | 1969-10-13 | ||
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
-
1968
- 1968-01-11 FR FR135641A patent/FR7337M/fr not_active Expired
- 1968-09-11 FR FR165812A patent/FR1584808A/fr not_active Expired
-
1969
- 1969-01-08 BE BE726610D patent/BE726610A/xx not_active IP Right Cessation
- 1969-01-10 CH CH25669A patent/CH506523A/fr not_active IP Right Cessation
- 1969-01-10 LU LU57758D patent/LU57758A1/xx unknown
- 1969-01-10 OA OA53473A patent/OA03363A/xx unknown
- 1969-01-13 NL NL696900544A patent/NL141187B/xx not_active IP Right Cessation
- 1969-01-13 GB GB0982/69A patent/GB1260868A/en not_active Expired
- 1969-09-17 FR FR696931578A patent/FR2062869B2/fr not_active Expired
-
1972
- 1972-07-17 US US00272375A patent/US3856967A/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0054417A1 (en) * | 1980-12-15 | 1982-06-23 | Pfizer Limited | Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them |
| US4478819A (en) * | 1982-04-26 | 1984-10-23 | Roussel Rclaf | Novel oral preparations |
| US4814501A (en) * | 1987-12-28 | 1989-03-21 | Merck & Co., Inc. | Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs |
| WO1993005019A1 (en) * | 1991-09-11 | 1993-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as 5-alpha-reductase inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| CH506523A (fr) | 1971-04-30 |
| US3856967A (en) | 1974-12-24 |
| BE726610A (forum.php) | 1969-07-08 |
| LU57758A1 (forum.php) | 1969-05-12 |
| FR7337M (forum.php) | 1969-10-13 |
| OA03363A (fr) | 1970-12-15 |
| DE1901167B2 (de) | 1977-03-17 |
| FR2062869B2 (forum.php) | 1973-08-10 |
| FR1584808A (forum.php) | 1970-01-02 |
| NL141187B (nl) | 1974-02-15 |
| FR2062869A2 (forum.php) | 1971-07-02 |
| DE1901167A1 (de) | 1969-12-11 |
| NL6900544A (forum.php) | 1969-07-15 |
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