GB1256849A - - Google Patents
Info
- Publication number
- GB1256849A GB1256849A GB1256849DA GB1256849A GB 1256849 A GB1256849 A GB 1256849A GB 1256849D A GB1256849D A GB 1256849DA GB 1256849 A GB1256849 A GB 1256849A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrimidine
- alkoxy
- halogen atom
- benzyloxy group
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- NHZLNPMOSADWGC-UHFFFAOYSA-N 4-amino-N-(2-quinoxalinyl)benzenesulfonamide Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(C=CC=C2)C2=N1 NHZLNPMOSADWGC-UHFFFAOYSA-N 0.000 abstract 1
- ORWKAFKIAPHHBG-UHFFFAOYSA-N 4-amino-n-(4,5-dimethoxypyrimidin-2-yl)benzenesulfonamide Chemical compound N1=C(OC)C(OC)=CN=C1NS(=O)(=O)C1=CC=C(N)C=C1 ORWKAFKIAPHHBG-UHFFFAOYSA-N 0.000 abstract 1
- XHPZVBGIPQQTQW-UHFFFAOYSA-N 5-benzylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=NC=C1CC1=CC=CC=C1 XHPZVBGIPQQTQW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 abstract 1
- 229960005404 sulfamethoxazole Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH897069A CH513181A (de) | 1969-06-12 | 1969-06-12 | Verfahren zur Herstellung von N-Oxyden von Benzylpyrimidinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1256849A true GB1256849A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-12-15 |
Family
ID=4346865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1256849D Expired GB1256849A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-06-12 | 1970-06-08 |
Country Status (18)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119095B2 (en) * | 2001-11-20 | 2006-10-10 | Dana Farber Cancer Institute | Pharmaceutically active compounds and methods of use thereof |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993761A (en) * | 1971-12-01 | 1976-11-23 | Hoffmann-La Roche Inc. | Antibacterial compositions |
| BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
| AR204082A1 (es) * | 1972-06-26 | 1975-11-20 | Hoffmann La Roche | Procedimiento para preparar derivados de n-oxidos de 2,4-diamino-5-(3-metoxi-4,5-metilendioxibencil)pirimidina |
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| CH591457A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-11-08 | 1977-09-15 | Hoffmann La Roche | |
| US4076810A (en) * | 1973-11-08 | 1978-02-28 | Hoffmann-La Roche Inc. | Benzylpyrimidine antibacterial composition |
| CA2557372C (en) * | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| WO2007025901A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| ES2612890T3 (es) * | 2005-09-01 | 2017-05-19 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P2X2/3 |
| MX2008002731A (es) * | 2005-09-01 | 2008-03-26 | Hoffmann La Roche | Diaminopirimidinas como moduladores de p2x3 y p3x2/3. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2518130A (en) * | 1945-04-26 | 1950-08-08 | Evans | N-oxides of tertiary amines and process of preparing same |
| US2500131A (en) * | 1945-06-27 | 1950-03-07 | Ralph L Evans | Di-nu-oxides of amino-substituted acridines and quinolines |
| US3159628A (en) * | 1962-05-28 | 1964-12-01 | Smith Kline French Lab | Pteridine-5-oxide derivatives |
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
| FR1453056A (fr) * | 1964-11-12 | 1966-04-15 | Hoffmann La Roche | Procédé pour la préparation de dérivés de pyrimidine |
| US3382247A (en) * | 1965-11-01 | 1968-05-07 | Upjohn Co | 6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines |
| US3464987A (en) * | 1966-02-21 | 1969-09-02 | Upjohn Co | 1,2-dihydro-1-hydroxy-2-imino-6-(lower alkyl)pyrimidines |
-
1969
- 1969-06-12 CH CH897069A patent/CH513181A/de not_active IP Right Cessation
- 1969-12-15 BR BR215095/69A patent/BR6915095D0/pt unknown
-
1970
- 1970-05-25 YU YU01328/70A patent/YU33390B/xx unknown
- 1970-05-26 ZA ZA703569A patent/ZA703569B/xx unknown
- 1970-06-01 IL IL34632A patent/IL34632A/xx unknown
- 1970-06-02 SE SE07642/70A patent/SE367412B/xx unknown
- 1970-06-02 DE DE19702026997 patent/DE2026997A1/de active Pending
- 1970-06-04 US US00043607A patent/US3715357A/en not_active Expired - Lifetime
- 1970-06-08 GB GB1256849D patent/GB1256849A/en not_active Expired
- 1970-06-09 IE IE745/70A patent/IE34683B1/xx unknown
- 1970-06-11 BE BE751790D patent/BE751790A/xx unknown
- 1970-06-11 ES ES380642A patent/ES380642A1/es not_active Expired
- 1970-06-11 CA CA085,216A patent/CA955944A/en not_active Expired
- 1970-06-11 AT AT526070A patent/AT294843B/de not_active IP Right Cessation
- 1970-06-11 FR FR707021418A patent/FR2052954B1/fr not_active Expired
- 1970-06-11 DK DK303870AA patent/DK124682B/da unknown
- 1970-06-11 NO NO02284/70A patent/NO127237B/no unknown
- 1970-06-12 NL NL7008610A patent/NL7008610A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119095B2 (en) * | 2001-11-20 | 2006-10-10 | Dana Farber Cancer Institute | Pharmaceutically active compounds and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| IE34683B1 (en) | 1975-07-23 |
| CA955944A (en) | 1974-10-08 |
| FR2052954B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-08-10 |
| BR6915095D0 (pt) | 1973-03-08 |
| BE751790A (fr) | 1970-12-11 |
| YU33390B (en) | 1976-12-31 |
| IE34683L (en) | 1970-12-12 |
| IL34632A0 (en) | 1970-08-19 |
| US3715357A (en) | 1973-02-06 |
| FR2052954A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-04-16 |
| NO127237B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-05-28 |
| CH513181A (de) | 1971-09-30 |
| DE2026997A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-12-23 |
| AT294843B (de) | 1971-12-10 |
| ES380642A1 (es) | 1972-10-16 |
| DK124682B (da) | 1972-11-13 |
| ZA703569B (en) | 1971-01-27 |
| IL34632A (en) | 1973-08-29 |
| NL7008610A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-12-15 |
| YU132870A (en) | 1976-06-30 |
| SE367412B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |