GB1256803A - - Google Patents
Info
- Publication number
- GB1256803A GB1256803A GB1256803DA GB1256803A GB 1256803 A GB1256803 A GB 1256803A GB 1256803D A GB1256803D A GB 1256803DA GB 1256803 A GB1256803 A GB 1256803A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- estra
- propynyl
- triene
- tetrahydropyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 abstract 2
- AEJRAAKERYIQGC-WAKWQXKPSA-N (8S,9S,13S,14S,17R)-3-butoxy-13-methyl-17-prop-1-ynyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene Chemical compound C(CCC)OC1=CC=2CC[C@H]3[C@@H]4CC[C@H]([C@@]4(C)CC[C@@H]3C=2C=C1)C#CC AEJRAAKERYIQGC-WAKWQXKPSA-N 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940126214 compound 3 Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002091 deciduogenic effect Effects 0.000 abstract 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical class CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70664968A | 1968-02-19 | 1968-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1256803A true GB1256803A (forum.php) | 1971-12-15 |
Family
ID=24838493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1256803D Expired GB1256803A (forum.php) | 1968-02-19 | 1969-02-03 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3487155A (forum.php) |
| BE (1) | BE728559A (forum.php) |
| CH (1) | CH501608A (forum.php) |
| DE (1) | DE1907330A1 (forum.php) |
| DK (1) | DK123232B (forum.php) |
| FR (1) | FR2002160A1 (forum.php) |
| GB (1) | GB1256803A (forum.php) |
| IL (1) | IL31639A0 (forum.php) |
| NL (1) | NL6902423A (forum.php) |
| SE (1) | SE350489B (forum.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1427141A (en) * | 1972-05-03 | 1976-03-10 | Bdh Pharmaceuticals Ltd | 17-alka-1,3-diynyl- steroids |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| DE69922684T2 (de) | 1998-08-11 | 2005-10-06 | Entremed, Inc. | Verwendung von 2-methoxyestradiol als fungizide |
| US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE564226A (forum.php) * | ||||
| FR1327004A (fr) * | 1958-05-20 | 1963-05-17 | British Drug Houses Ltd | Procédé de fabrication de 17beta-hydroxy-17alpha-alkynyl-stéroïdes de l'androstane et du 3,5-cyclo-androstane |
| BE641351A (forum.php) * | 1962-12-19 | |||
| NL128376C (forum.php) * | 1964-04-23 |
-
1968
- 1968-02-19 US US706649A patent/US3487155A/en not_active Expired - Lifetime
-
1969
- 1969-01-28 CH CH124969A patent/CH501608A/de not_active IP Right Cessation
- 1969-02-03 DK DK58269AA patent/DK123232B/da unknown
- 1969-02-03 GB GB1256803D patent/GB1256803A/en not_active Expired
- 1969-02-07 SE SE01671/69A patent/SE350489B/xx unknown
- 1969-02-14 NL NL6902423A patent/NL6902423A/xx unknown
- 1969-02-14 DE DE19691907330 patent/DE1907330A1/de active Pending
- 1969-02-17 BE BE728559D patent/BE728559A/xx unknown
- 1969-02-17 IL IL31639A patent/IL31639A0/xx unknown
- 1969-02-17 FR FR6903863A patent/FR2002160A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| SE350489B (forum.php) | 1972-10-30 |
| US3487155A (en) | 1969-12-30 |
| BE728559A (forum.php) | 1969-08-18 |
| NL6902423A (forum.php) | 1969-08-21 |
| DK123232B (da) | 1972-05-29 |
| FR2002160A1 (forum.php) | 1969-10-17 |
| CH501608A (de) | 1971-01-15 |
| IL31639A0 (en) | 1969-04-30 |
| DE1907330A1 (de) | 1969-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |