GB1187259A - New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture - Google Patents
New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufactureInfo
- Publication number
- GB1187259A GB1187259A GB48138/67A GB4813867A GB1187259A GB 1187259 A GB1187259 A GB 1187259A GB 48138/67 A GB48138/67 A GB 48138/67A GB 4813867 A GB4813867 A GB 4813867A GB 1187259 A GB1187259 A GB 1187259A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- acid
- represent
- anilino
- piperazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004103 aminoalkyl group Chemical group 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- UUMMTMQODCACRH-UHFFFAOYSA-N 2-anilinopyridine-3-carboxylic acid Chemical class OC(=O)C1=CC=CN=C1NC1=CC=CC=C1 UUMMTMQODCACRH-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- -1 pyrrolidino, piperazino Chemical group 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Toys (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB48138/67A GB1187259A (en) | 1967-10-23 | 1967-10-23 | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
| FR168642A FR7963M (OSRAM) | 1967-10-23 | 1968-10-03 | |
| BE721949D BE721949A (OSRAM) | 1967-10-23 | 1968-10-07 | |
| DE19681802777 DE1802777C3 (de) | 1967-10-23 | 1968-10-12 | Aminoalkylester der 2-Anilinonicotinsäure |
| NL6814726.A NL156136B (nl) | 1967-10-23 | 1968-10-15 | Werkwijze voor het bereiden van ontstekingsremmende verbindingen en geneesmiddelen, alsmede aldus verkregen gevormde geneesmiddelen. |
| AT1008268A AT279613B (de) | 1967-10-23 | 1968-10-16 | Verfahren zur Herstellung von neuen Aminoalkylestern von 2-Anilinonikotinsäuren und ihrer Säureadditionssalze |
| SE14009/68A SE335982B (OSRAM) | 1967-10-23 | 1968-10-17 | |
| US00768903A US3708481A (en) | 1967-10-23 | 1968-10-18 | 2-anilino-nicotinic acid esters |
| NO04165/68A NO129146B (OSRAM) | 1967-10-23 | 1968-10-22 | |
| DK507968AA DK126783B (da) | 1967-10-23 | 1968-10-22 | Analogifremgangsmåde til fremstilling af aminoalkylestere af 2-anilinonicotinsyrer eller syreadditionssalte heraf. |
| CH1578168A CH493518A (fr) | 1967-10-23 | 1968-10-22 | Procédé de préparation d'esters amino alcoylés d'acides anilino-2 nicotiniques |
| ES359454A ES359454A1 (es) | 1967-10-23 | 1968-10-23 | Procedimiento de preparacion de nuevos esteres aminoalcohi-lados de acidos anilino-2 nicotinico. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB48138/67A GB1187259A (en) | 1967-10-23 | 1967-10-23 | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1187259A true GB1187259A (en) | 1970-04-08 |
Family
ID=10447527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48138/67A Expired GB1187259A (en) | 1967-10-23 | 1967-10-23 | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3708481A (OSRAM) |
| AT (1) | AT279613B (OSRAM) |
| BE (1) | BE721949A (OSRAM) |
| CH (1) | CH493518A (OSRAM) |
| DK (1) | DK126783B (OSRAM) |
| ES (1) | ES359454A1 (OSRAM) |
| FR (1) | FR7963M (OSRAM) |
| GB (1) | GB1187259A (OSRAM) |
| NL (1) | NL156136B (OSRAM) |
| NO (1) | NO129146B (OSRAM) |
| SE (1) | SE335982B (OSRAM) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0016460A1 (en) * | 1979-03-27 | 1980-10-01 | NEOPHARMED S.p.A. | Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition |
| WO2008029199A1 (en) * | 2006-09-03 | 2008-03-13 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| WO2008149181A1 (en) | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| JP2015120703A (ja) * | 2015-01-05 | 2015-07-02 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| CN105669531A (zh) * | 2007-06-04 | 2016-06-15 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
| JP2017105853A (ja) * | 2017-03-22 | 2017-06-15 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| JP2020147604A (ja) * | 2020-06-17 | 2020-09-17 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| US11813256B2 (en) | 2012-01-18 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2544718B1 (fr) * | 1983-04-21 | 1985-12-20 | Hexachimie | Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire |
| DE3320582A1 (de) * | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Gliquidonhaltige zubereitungsformen und verfahren zu ihrer herstellung |
-
1967
- 1967-10-23 GB GB48138/67A patent/GB1187259A/en not_active Expired
-
1968
- 1968-10-03 FR FR168642A patent/FR7963M/fr not_active Expired
- 1968-10-07 BE BE721949D patent/BE721949A/xx not_active IP Right Cessation
- 1968-10-15 NL NL6814726.A patent/NL156136B/xx not_active IP Right Cessation
- 1968-10-16 AT AT1008268A patent/AT279613B/de not_active IP Right Cessation
- 1968-10-17 SE SE14009/68A patent/SE335982B/xx unknown
- 1968-10-18 US US00768903A patent/US3708481A/en not_active Expired - Lifetime
- 1968-10-22 NO NO04165/68A patent/NO129146B/no unknown
- 1968-10-22 CH CH1578168A patent/CH493518A/fr not_active IP Right Cessation
- 1968-10-22 DK DK507968AA patent/DK126783B/da unknown
- 1968-10-23 ES ES359454A patent/ES359454A1/es not_active Expired
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0016460A1 (en) * | 1979-03-27 | 1980-10-01 | NEOPHARMED S.p.A. | Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| CN101506168B (zh) * | 2006-09-03 | 2014-12-10 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的芳基邻氨基苯甲酸的前药 |
| WO2008029199A1 (en) * | 2006-09-03 | 2008-03-13 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| EP2623495A1 (en) * | 2006-09-03 | 2013-08-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| AU2007354632B2 (en) * | 2007-06-04 | 2014-06-26 | Techfields Inc | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
| CN105669531B (zh) * | 2007-06-04 | 2019-05-07 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
| CN105669531A (zh) * | 2007-06-04 | 2016-06-15 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
| US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
| WO2008149181A1 (en) | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| RU2509076C2 (ru) * | 2007-06-04 | 2014-03-10 | Текфилдз Инк | Пролекарства нестероидных противовоспалительных средств (nsaia) c очень высокой скоростью проникновения через кожу и мембраны и новые медицинские применения указанных пролекарств |
| US10233198B2 (en) | 2007-06-04 | 2019-03-19 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| US11813256B2 (en) | 2012-01-18 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
| US11857545B2 (en) | 2012-01-18 | 2024-01-02 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| JP2015120703A (ja) * | 2015-01-05 | 2015-07-02 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| JP2017105853A (ja) * | 2017-03-22 | 2017-06-15 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| JP2020147604A (ja) * | 2020-06-17 | 2020-09-17 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| JP2024026659A (ja) * | 2020-06-17 | 2024-02-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES359454A1 (es) | 1970-06-01 |
| NL6814726A (OSRAM) | 1969-04-25 |
| BE721949A (OSRAM) | 1969-03-14 |
| SE335982B (OSRAM) | 1971-06-21 |
| DK126783B (da) | 1973-08-20 |
| DE1802777A1 (de) | 1969-06-19 |
| CH493518A (fr) | 1970-07-15 |
| NO129146B (OSRAM) | 1974-03-04 |
| AT279613B (de) | 1970-03-10 |
| DE1802777B2 (de) | 1975-11-27 |
| US3708481A (en) | 1973-01-02 |
| NL156136B (nl) | 1978-03-15 |
| FR7963M (OSRAM) | 1970-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| PE20 | Patent expired after termination of 20 years |