GB1172341A - Oxazine Derivatives - Google Patents
Oxazine DerivativesInfo
- Publication number
- GB1172341A GB1172341A GB21182/68A GB2118268A GB1172341A GB 1172341 A GB1172341 A GB 1172341A GB 21182/68 A GB21182/68 A GB 21182/68A GB 2118268 A GB2118268 A GB 2118268A GB 1172341 A GB1172341 A GB 1172341A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- dihydro
- oxazine
- general formula
- morpholinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004893 oxazines Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 3
- PFNQUYDCULMOIH-UHFFFAOYSA-N 2-phenyl-3,6-dihydro-2H-1,4-oxazin-5-amine Chemical class NC=1COC(CN1)C1=CC=CC=C1 PFNQUYDCULMOIH-UHFFFAOYSA-N 0.000 abstract 2
- RTQVWPLQBMKYGK-UHFFFAOYSA-N 6-phenylmorpholin-3-one Chemical compound C1NC(=O)COC1C1=CC=CC=C1 RTQVWPLQBMKYGK-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
- KSUNFUKBLRVTIV-UHFFFAOYSA-N 2-phenyl-3,6-dihydro-2H-1,4-oxazine Chemical compound C1(=CC=CC=C1)C1CN=CCO1 KSUNFUKBLRVTIV-UHFFFAOYSA-N 0.000 abstract 1
- XUOOPHVVDZIYJP-UHFFFAOYSA-N 5-ethoxy-2-phenyl-3,6-dihydro-2H-1,4-oxazine Chemical compound C(C)OC=1COC(CN1)C1=CC=CC=C1 XUOOPHVVDZIYJP-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 230000002891 anorexigenic effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- VEUUMBGHMNQHGO-UHFFFAOYSA-N ethyl chloroacetate Chemical compound CCOC(=O)CCl VEUUMBGHMNQHGO-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical compound NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- DWCSXQCXXITVKE-UHFFFAOYSA-N triethyloxidanium Chemical compound CC[O+](CC)CC DWCSXQCXXITVKE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR105382 | 1967-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1172341A true GB1172341A (en) | 1969-11-26 |
Family
ID=8630295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21182/68A Expired GB1172341A (en) | 1967-05-05 | 1968-05-03 | Oxazine Derivatives |
Country Status (7)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2178754A1 (en) * | 1972-04-05 | 1973-11-16 | Delalande Sa | 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc |
| CA2800219C (en) | 2010-05-21 | 2019-03-12 | Research Triangle Institute | 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence |
| JP2013526583A (ja) | 2010-05-21 | 2013-06-24 | リサーチ・トライアングル・インスティチュート | フェニルモルホリンおよびその類似体 |
-
1962
- 1962-05-05 FR FR105382A patent/FR1558915A/fr not_active Expired
-
1967
- 1967-08-02 FR FR116659A patent/FR6645M/fr not_active Expired
-
1968
- 1968-04-26 NL NL6805987A patent/NL6805987A/xx unknown
- 1968-05-02 US US726235A patent/US3555019A/en not_active Expired - Lifetime
- 1968-05-03 DE DE19681770325 patent/DE1770325A1/de active Pending
- 1968-05-03 CH CH657268A patent/CH485761A/fr not_active IP Right Cessation
- 1968-05-03 BE BE714665D patent/BE714665A/xx unknown
- 1968-05-03 GB GB21182/68A patent/GB1172341A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3555019A (en) | 1971-01-12 |
| FR1558915A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-03-07 |
| FR6645M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-01-20 |
| CH485761A (fr) | 1970-02-15 |
| NL6805987A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-06 |
| BE714665A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-04 |
| DE1770325A1 (de) | 1971-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |