GB1154317A - Oral Vehicle for Administering Drugs by Buccal Absorption - Google Patents
Oral Vehicle for Administering Drugs by Buccal AbsorptionInfo
- Publication number
- GB1154317A GB1154317A GB2516265A GB2516265A GB1154317A GB 1154317 A GB1154317 A GB 1154317A GB 2516265 A GB2516265 A GB 2516265A GB 2516265 A GB2516265 A GB 2516265A GB 1154317 A GB1154317 A GB 1154317A
- Authority
- GB
- United Kingdom
- Prior art keywords
- layer
- drug
- vehicle
- gelatine
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1,154,317. Oral shapes and forms. H. S. RUSSELL. 30 Aug., 1966 [15 June, 1965], No. 25162/65. Heading A5B. An oral vehicle for administering drugs by buccal absorption takes the form of a thin resilient body having a concave depression in at least one of its major surfaces, the body comprising a first layer at least part of which is soluble in and/or permeable to saliva and incorporates a drug absorbable by the oral mucous membranes, and a second layer having a different solubility and/or permeability and either containing a different drug or lacking any drug content the first layer may be formed of a soluble absorbable drug impregnated material such as an alginate, methyl cellulose, or preferably a glyco-gelatine, (gelatine having a suitable water content and plasticised with glycerol), and may be foamed or spongy. Alternatively this layer may consist of a matrix of porous spongy or foamed insoluble material, e.g. polyurethane, natural or synthetic rubber, polyvinyl chloride or sulphonated gelatine, impregnated with a mixture of the drug and a viscous settable liquid soluble in saliva, e.g. melted glyco-gelatin, which is then caused to set, the matrix being shaped if required during such setting. The second layer, which covers all the surfaces of the first layer except that having the depression, is either 1) more, or 2) less soluble and/or permeable than the first layer. In the case of 1) the second layer may be a sheet material, eg. treated paper, metal foil, plastics film, or an adherent coating, eg. of varnish, hard glyco-gelatine or sulphonated gelatine; for 2) a layer or coating of soft glyco-gelatine, with a high content of water and glycerine, is employed. Alternatively the two layers may be of the same material, with the second layer being thicker than the first. The vehicle may incorporate a third layer of insoluble material, eg. treated paper, metal foil, plastics film or varnish, either interposed between the first and second layer or as a coating on the outer surface of the second layer, and also may be provided with a protective backing on the concave face or both faces, which is to be removed before use of the vehicle; such a backing may connect several vehicles to form a strip. The vehicle is made 1) by coating the first layer with a melt or solution of the second layer material which is then set or dried. 2) by coating one side of a capsule of soluble permeable material with an impervious coating, the capsule containing a solution of the drug in a volatile solvent, and then drying the capsule, when the solvent migrates and evaporates through the uncoated capsule wall, depositing the drug therein, this wall ultimately collapsing inwards to give the required depression. The capsule may have an internal dividing partition. 3) A procedure similar to that of 2) may be employed using a capsule of homogenous composition but wherein the wall of one hemisphere is thicker than the opposite wall, preferential migration of the drug solution ocurring through the thinner wall, to give a vehicle having layers of the same composition but different thickness with the drug in the thinner layer. 4) The vehicle may be stamped out of a two-layered strip and then shaped to provide the depression. 5) The drug is incorporated into one side only of a preformed vehicle having one side protected by an impervious layer by exposing it to an aqueous or other solution of the drug which is absorbed by the unprotected side only, the vehicle afterwards being dried. Suitable drugs are: polypeptide and steroid hormones, e.g. vasopressin, insulin, oxytocin, heparin, testosterone, oestrpgens and progesterones: anaesthetics, e.g. hydrochlorides of lignocaine and diperodlon; sympathomimetic amines, e.g. adrenaline, nor-adrenaline, isoprenaline and amphetamine, and their antagonists, e.g. ergotamine, dibenylene; and various others such as morphine, glyceryl trinitrate, digitalin, barbiturates, acetyl choline, physistigmine, promethazine, atropine, hyoscine, amyl nitrate, caffeine, cyanocobalamin, para-amino-hippuric acid, and radio-isotopes. The vehicle may include a skin penetration promoter such as dimethyl sulphoxide.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2516265A GB1154317A (en) | 1965-06-15 | 1965-06-15 | Oral Vehicle for Administering Drugs by Buccal Absorption |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2516265A GB1154317A (en) | 1965-06-15 | 1965-06-15 | Oral Vehicle for Administering Drugs by Buccal Absorption |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1154317A true GB1154317A (en) | 1969-06-04 |
Family
ID=10223238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2516265A Expired GB1154317A (en) | 1965-06-15 | 1965-06-15 | Oral Vehicle for Administering Drugs by Buccal Absorption |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1154317A (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2514642A1 (en) * | 1981-10-20 | 1983-04-22 | Sandoz Sa | DELAYED RELEASE PHARMACEUTICAL COMPOSITIONS |
GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
EP1686935A2 (en) * | 2003-10-22 | 2006-08-09 | University Hospitals Of Cleveland | Method and apparatus for applying medication to internal tissue |
WO2007084617A2 (en) * | 2006-01-20 | 2007-07-26 | Monosol Rx, Llc | Film bandage for mucosal administration of actives |
EP2042161A1 (en) * | 1997-10-01 | 2009-04-01 | Novadel Pharma Inc. | Propellant-free spray composition comprising anti-emetic agent |
US8236285B2 (en) | 1997-10-01 | 2012-08-07 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
US8652378B1 (en) | 2001-10-12 | 2014-02-18 | Monosol Rx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8906277B2 (en) | 2001-10-12 | 2014-12-09 | Monosol Rx, Llc | Process for manufacturing a resulting pharmaceutical film |
US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US10821074B2 (en) | 2009-08-07 | 2020-11-03 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US11077068B2 (en) | 2001-10-12 | 2021-08-03 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
-
1965
- 1965-06-15 GB GB2516265A patent/GB1154317A/en not_active Expired
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3237945A1 (en) * | 1981-10-20 | 1983-05-05 | Sandoz-Patent-GmbH, 7850 Lörrach | PHARMACEUTICAL COMPOSITIONS WITH DELAYED DELIVERY |
FR2514642A1 (en) * | 1981-10-20 | 1983-04-22 | Sandoz Sa | DELAYED RELEASE PHARMACEUTICAL COMPOSITIONS |
GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
EP2042161A1 (en) * | 1997-10-01 | 2009-04-01 | Novadel Pharma Inc. | Propellant-free spray composition comprising anti-emetic agent |
US8236285B2 (en) | 1997-10-01 | 2012-08-07 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
US10888499B2 (en) | 2001-10-12 | 2021-01-12 | Aquestive Therapeutics, Inc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US9931305B2 (en) | 2001-10-12 | 2018-04-03 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US11077068B2 (en) | 2001-10-12 | 2021-08-03 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8652378B1 (en) | 2001-10-12 | 2014-02-18 | Monosol Rx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8906277B2 (en) | 2001-10-12 | 2014-12-09 | Monosol Rx, Llc | Process for manufacturing a resulting pharmaceutical film |
US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US9855221B2 (en) | 2001-10-12 | 2018-01-02 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US10111810B2 (en) | 2002-04-11 | 2018-10-30 | Aquestive Therapeutics, Inc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
EP1686935A2 (en) * | 2003-10-22 | 2006-08-09 | University Hospitals Of Cleveland | Method and apparatus for applying medication to internal tissue |
EP1686935A4 (en) * | 2003-10-22 | 2009-06-17 | Univ Cleveland Hospitals | Method and apparatus for applying medication to internal tissue |
WO2007084617A3 (en) * | 2006-01-20 | 2008-03-13 | Monosolrx Llc | Film bandage for mucosal administration of actives |
WO2007084617A2 (en) * | 2006-01-20 | 2007-07-26 | Monosol Rx, Llc | Film bandage for mucosal administration of actives |
US10821074B2 (en) | 2009-08-07 | 2020-11-03 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10940626B2 (en) | 2010-10-22 | 2021-03-09 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
US12023309B2 (en) | 2016-05-05 | 2024-07-02 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
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