GB1145543A - Chloropregnanes - Google Patents
ChloropregnanesInfo
- Publication number
- GB1145543A GB1145543A GB2780467A GB2780467A GB1145543A GB 1145543 A GB1145543 A GB 1145543A GB 2780467 A GB2780467 A GB 2780467A GB 2780467 A GB2780467 A GB 2780467A GB 1145543 A GB1145543 A GB 1145543A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- analogues
- novel
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1,145,543. 20-Chloropregnenes. DEUTSCHE AKADEMIE DER WISSENSCHAFTEN ZU BERLIN. 16 June, 1967, No. 27804/67. Heading C2U. Novel 20-chloro-pregnenes of the formula (wherein R is hydrogen or acetyl) and their novel #<SP>1</SP>'<SP>4</SP> analogues are prepared from #<SP>5</SP>- spirosolane alkaloids of the formula by reducing them with NaBH 4 to obtain compounds of the formula Oppenauer oxidation of the latter yields the corresponding 3-keto-#<SP>4</SP> compounds which are then N-chlorinated with N-chlorosuccinimide, the resulting N-chloro compounds being then irradiated with U.V. light in the presence of an acid (e.g. trifluoroacetic to obtain a mixture of isomers (20-S and 20-R) of Formula IV (R = H) which may be separated chromatographically. The #<SP>1,4</SP> analogues are obtainedbydehydrogenation of compounds of Formula IV (e.g. with dichlorodicyanobenzoquinone) and 16#-acetoxy derivatives are obtained from the hydroxy compounds by acetylation
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2780467A GB1145543A (en) | 1967-06-16 | 1967-06-16 | Chloropregnanes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2780467A GB1145543A (en) | 1967-06-16 | 1967-06-16 | Chloropregnanes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1145543A true GB1145543A (en) | 1969-03-19 |
Family
ID=10265580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2780467A Expired GB1145543A (en) | 1967-06-16 | 1967-06-16 | Chloropregnanes |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1145543A (en) |
-
1967
- 1967-06-16 GB GB2780467A patent/GB1145543A/en not_active Expired
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