GB1073988A - Process for preparing steroid compounds, and the compounds thus prepared - Google Patents
Process for preparing steroid compounds, and the compounds thus preparedInfo
- Publication number
- GB1073988A GB1073988A GB32261/64A GB3226164A GB1073988A GB 1073988 A GB1073988 A GB 1073988A GB 32261/64 A GB32261/64 A GB 32261/64A GB 3226164 A GB3226164 A GB 3226164A GB 1073988 A GB1073988 A GB 1073988A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydroxy
- keto
- ethylidene
- steroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 steroid compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000468 ketone group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052698 phosphorus Inorganic materials 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- JPLNTUIOHGWUTM-OCABDXPQSA-N (8R,9R,10S,13S,14S)-3-amino-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one Chemical compound NC1=CC2=CC[C@H]3[C@@H]4CCC([C@@]4(C)CC[C@H]3[C@@H]2CC1)=O JPLNTUIOHGWUTM-OCABDXPQSA-N 0.000 abstract 1
- OUMJFKRRKBCWNJ-BQEVRZRTSA-N (8S,9S,10R,13S,14S)-3-amino-13-methyl-10-propyl-2,7,8,9,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-11,17-dione Chemical compound NC1=CC2=CC[C@H]3[C@@H]4CCC([C@@]4(C)CC([C@@H]3[C@]2(CC1)CCC)=O)=O OUMJFKRRKBCWNJ-BQEVRZRTSA-N 0.000 abstract 1
- RZRPTBIGEANTGU-UHFFFAOYSA-N -Androst-4-ene-3,11,17-trione Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)=O)C4C3CCC2=C1 RZRPTBIGEANTGU-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- CWDJTDJQVUXQEA-UHFFFAOYSA-N CC=[PH3] Chemical compound CC=[PH3] CWDJTDJQVUXQEA-UHFFFAOYSA-N 0.000 abstract 1
- 229930194542 Keto Natural products 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- NINLAYUXSUKKHW-UHFFFAOYSA-N androsta-3,5(6)-dien-17-one Natural products C1=CCCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 NINLAYUXSUKKHW-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- NNQYFBSGBOKZKP-UHFFFAOYSA-N ethylidene(triphenyl)-$l^{5}-phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC)C1=CC=CC=C1 NNQYFBSGBOKZKP-UHFFFAOYSA-N 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000005805 hydroxylation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
- 150000003122 pregn-4-en-3-ones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR944032A FR1453220A (fr) | 1963-08-07 | 1963-08-07 | Lactones stéroïdes et procédé de préparation |
| FR944033A FR1453221A (fr) | 1963-08-07 | 1963-08-07 | Nouveau procédé de préparation de dérivés stéroïdes |
| FR960549A FR1468646A (fr) | 1963-08-07 | 1964-01-16 | Nouveau procédé de préparation de composés stéroïdes 10 alcoylés |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1073988A true GB1073988A (en) | 1967-06-28 |
Family
ID=27247393
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB54690/66A Expired GB1073989A (en) | 1963-08-07 | 1964-08-07 | 10ª‰-n-propyl steroids and processes for their preparation |
| GB32261/64A Expired GB1073988A (en) | 1963-08-07 | 1964-08-07 | Process for preparing steroid compounds, and the compounds thus prepared |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB54690/66A Expired GB1073989A (en) | 1963-08-07 | 1964-08-07 | 10ª‰-n-propyl steroids and processes for their preparation |
Country Status (8)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2704130A1 (de) * | 1977-01-28 | 1978-08-10 | Schering Ag | Verfahren zur herstellung von 17 beta- hydroxy-20-alkoxy-pregnan-21-saeure-derivaten |
| FR2552766B1 (fr) * | 1983-10-04 | 1987-06-26 | Theramex | Nouveau procede de preparation de derives de la serie du 17 a-hydroxy 19-nor progesterone |
| JPH0772194B2 (ja) * | 1985-09-03 | 1995-08-02 | ラボラトア−ル、テラメツクス | １７α−ヒドロキシ−１９−ノルプロゲステロン誘導体の新規製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2781342A (en) * | 1952-05-17 | 1957-02-12 | Upjohn Co | Steroid enamines |
| US2752366A (en) * | 1952-11-06 | 1956-06-26 | Upjohn Co | Carbonyloxysteroids |
| US2793217A (en) * | 1953-06-27 | 1957-05-21 | Lab Francais Chimiotherapie | New derivatives of adrenosterone and a process of making same |
| US2990415A (en) * | 1955-03-29 | 1961-06-27 | American Cyanamid Co | 9-substituted delta4-androstenes |
| US2955075A (en) * | 1957-04-15 | 1960-10-04 | Olin Mathieson | Synthesis of steroids by cylindrocarpon radicicola |
| US3114757A (en) * | 1961-09-22 | 1963-12-17 | Upjohn Co | 6-fluoro-3, 11-diketo-delta4, 17(20)-pregnadien-21-oic acid esters |
-
0
- NL NL123298D patent/NL123298C/xx active
-
1963
- 1963-08-07 FR FR944032A patent/FR1453220A/fr not_active Expired
- 1963-08-07 FR FR944033A patent/FR1453221A/fr not_active Expired
-
1964
- 1964-01-16 FR FR960549A patent/FR1468646A/fr not_active Expired
- 1964-07-27 CH CH984264A patent/CH453347A/fr unknown
- 1964-07-30 US US386375A patent/US3383385A/en not_active Expired - Lifetime
- 1964-08-04 DE DE1964R0045222 patent/DE1618808B1/de not_active Withdrawn
- 1964-08-04 DE DE19641468880 patent/DE1468880B1/de active Pending
- 1964-08-04 DE DE1964R0045220 patent/DE1618806B1/de active Pending
- 1964-08-06 IL IL21864A patent/IL21864A/xx unknown
- 1964-08-06 IL IL32873A patent/IL32873A/xx unknown
- 1964-08-07 NL NL6409130A patent/NL6409130A/xx unknown
- 1964-08-07 GB GB54690/66A patent/GB1073989A/en not_active Expired
- 1964-08-07 GB GB32261/64A patent/GB1073988A/en not_active Expired
- 1964-08-07 JP JP39044975A patent/JPS4821104B1/ja active Pending
-
1973
- 1973-01-20 JP JP48008298A patent/JPS5034555B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1618806B1 (de) | 1971-11-18 |
| JPS4821104B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-06-26 |
| DE1468880B1 (de) | 1970-04-23 |
| FR1468646A (fr) | 1967-02-10 |
| IL21864A (en) | 1970-01-29 |
| FR1453221A (fr) | 1966-06-03 |
| DE1618808B1 (de) | 1971-11-11 |
| NL123298C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| GB1073989A (en) | 1967-06-28 |
| FR1453220A (fr) | 1966-06-03 |
| US3383385A (en) | 1968-05-14 |
| JPS5034555B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-11-10 |
| NL6409130A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1965-02-08 |
| CH453347A (fr) | 1968-06-14 |
| IL32873A (en) | 1970-11-30 |
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